Consolidated Statements of Operations - USD ($) shares in Thousands, $ in Thousands	3 Months Ended		6 Months Ended
	Jun. 30, 2018	Jun. 30, 2017	Jun. 30, 2018	Jun. 30, 2017
Revenues:
Total net revenues	$ 153,302	$ 139,438	$ 259,467	$ 258,824
Costs and expenses:
Cost of sales	31,094	29,665	52,444	54,848
Cost of license revenue		159		317
Research and development	25,910	51,184	56,470	97,677
Selling, general and administrative	44,263	49,334	91,864	101,359
Changes in fair value of acquired contingent consideration	(7,000)	6,400	(800)	17,200
Total operating expenses	94,267	136,742	199,978	271,401
Operating income (loss)	59,035	2,696	59,489	(12,577)
Other (expense) income, net:
Interest and amortization of debt discount expense	(5,414)	(5,460)	(10,911)	(9,603)
Interest income	910	35	1,236	73
Realized (loss) gain on foreign currency transactions	(2)	4	(7)	(440)
Other income	24		24
Total other expense, net	(4,482)	(5,421)	(9,658)	(9,970)
Income (loss) before taxes	54,553	(2,725)	49,831	(22,547)
Provision for income taxes	(8,356)	(5,471)	(11,833)	(4,552)
Net income (loss)	$ 46,197	$ (8,196)	$ 37,998	$ (27,099)
Net income (loss) per share—basic	$ 0.99	$ (0.18)	$ 0.82	$ (0.59)
Net income (loss) per share—diluted	$ 0.98	$ (0.18)	$ 0.81	$ (0.59)
Weighted average common shares outstanding used in computing net income (loss) per share—basic	46,799	45,943	46,546	45,876
Weighted average common shares outstanding used in computing net income (loss) per share—diluted	47,201	45,943	46,974	45,876
Net Product Revenues
Revenues:
Total net revenues	$ 150,412	$ 132,756	$ 253,415	$ 245,349
Royalty Revenues
Revenues:
Total net revenues	$ 2,890	4,418	$ 6,052	8,946
License Revenue
Revenues:
Total net revenues		$ 2,264		$ 4,529