Consolidated Balance Sheets - USD ($)	Jun. 30, 2018	Dec. 31, 2017
Current assets:
Cash and cash equivalents	$ 243,345,000	$ 307,068,000
Restricted cash	221,000	410,000
Short term investments	148,371,000	0
Trade accounts receivable, net of allowances of $1,783 and $845, as of June 30, 2018 and December 31, 2017, respectively	64,360,000	81,403,000
Prepaid expenses	15,101,000	13,333,000
Finished goods inventory held by the Company	21,147,000	37,501,000
Other current assets	2,007,000	1,983,000
Total current assets	494,552,000	441,698,000
Property and equipment, net of accumulated depreciation	42,524,000	36,669,000
Goodwill	284,100,000	286,611,000
Intangible assets, net of accumulated amortization	428,762,000	430,603,000
Non-current portion of deferred cost of license revenue		1,638,000
Other assets	678,000	750,000
Total assets	1,250,616,000	1,197,969,000
Current liabilities:
Accounts payable	15,400,000	27,367,000
Accrued expenses and other current liabilities	97,761,000	100,128,000
Current portion of deferred license revenue		9,057,000
Current portion of loans payable	629,000	645,000
Current portion of liability related to sale of future royalties	7,081,000	6,763,000
Total current liabilities	120,871,000	143,960,000
Convertible senior notes (due 2021)	313,679,000	308,805,000
Non-current portion of acquired contingent consideration	109,174,000	112,722,000
Non-current portion of deferred license revenue		23,398,000
Non-current portion of loans payable	24,698,000	25,670,000
Deferred tax liability	37,586,000	22,459,000
Non-current portion of liability related to sale of future royalties	26,102,000	29,025,000
Other non-current liabilities	11,871,000	11,943,000
Commitments and contingencies
Stockholders’ equity:
Preferred stock, $0.001 par value. Authorized 20,000,000 shares at June 30, 2018 and December 31, 2017; no shares issued as of June 30, 2018 and December 31, 2017, respectively
Common stock, $0.001 par value. Authorized 80,000,000 shares at June 30, 2018 and December 31, 2017; issued 47,223,027 and 46,441,428 shares, including those held in treasury, as of June 30, 2018 and December 31, 2017, respectively	47,000	46,000
Treasury stock at cost (79,275 shares at June 30, 2018 and 16,151 shares at December 31, 2017)	(1,976,000)	(389,000)
Additional paid-in capital	993,292,000	968,580,000
Accumulated deficit	(389,527,000)	(455,108,000)
Accumulated other comprehensive income	4,799,000	6,858,000
Total stockholders’ equity	606,635,000	519,987,000
Total liabilities and stockholders’ equity	$ 1,250,616,000	$ 1,197,969,000