Income Taxes (Tables)

12 Months Ended

Dec. 31, 2017

Income Tax Disclosure [Abstract]

Schedule of Domestic and Foreign Components of (Loss) Income Before Income Taxes

(In thousands)	Year ended December 31,         2017			Year ended December 31,         2016			Year ended December 31,         2015
Domestic	$	(172,560	)	$	(36,454	)	$	16,284
Foreign		(79,325	)		(5,814	)		3,085
Total	$	(251,885	)	$	(42,268	)	$	19,369

Schedule of Benefit from (Provision for) Income Taxes

(In thousands)	Year ended December 31,         2017			Year ended December 31,         2016			Year ended December 31,         2015
Current:
Federal	$	(11,948	)	$	(852	)	$	(603	)
State		(12,653	)		(4,517	)		(2,773	)
Foreign		(91	)		781			(960	)
		(24,692	)		(4,588	)		(4,336	)
Deferred:
Federal		42,322			9,465			(2,960	)
State		5,377			1,788			(1,015	)
Foreign		5,519			—			—
		53,218			11,253			(3,975	)
Total benefit from (provision for) income taxes	$	28,526		$	6,665		$	(8,311	)

Schedule of Reconciliation of the Statutory U.S. Federal Income Tax Rate to the Entity's Effective Income Tax Rate

	Year ended December 31,         2017			Year ended December 31,         2016			Year ended December 31,         2015
U.S. federal statutory tax rate		35.0	%		35.0	%		35.0	%
State and local income taxes		(0.1	)%		(3.8	)%		13.3	%
Non-deductible payment to prior shareholders		—			—			15.8	%
Foreign income tax		—			1.2	%		3.2	%
Stock option compensation		(0.5	)%		(3.8	)%		10.4	%
Stock option shortfall		(1.5	)%		(6.5	)%		—
Research and development and orphan drug credits		1.2	%		28.9	%		(42.9	)%
Increase to Uncertain Tax Positions		(0.3	)%		(4.8	)%		7.1	%
Other nondeductible and permanent differences		(0.4	)%		(1.1	)%		1.9	%
Valuation allowance, net of foreign tax rate differential		(19.8	)%		(31.6	)%		(0.9	)%
Transaction cost		—			(5.9	)%		—
Gain or loss on hedging		—			8.2	%		—
Tax reform		(2.3	)%		—			—
Effective income tax rate		11.3	%		15.8	%		42.9	%

Schedule of Deferred Tax Assets and Liabilities

(In thousands)	December 31, 2017			December 31, 2016
Deferred tax assets:
Net operating loss and other carryforwards	$	53,632		$	97,391
Tax credits		31,699			35,489
Deferred revenue		5,597			11,672
Stock based compensation		24,531			34,700
Contingent consideration		26,041			26,543
Employee compensation		3,212			6,116
Legal reserve		—			2,707
Rebate and returns reserve		8,215			7,582
Capitalized R&D		11,295			10,025
Other		12,368			4,096
Total deferred tax assets	$	176,590		$	236,321
Valuation allowance	$	(98,609	)	$	(63,225	)
Total deferred tax assets net of valuation allowance	$	77,981		$	173,096
Deferred tax liabilities:
Intangible assets		(91,991	)		(245,500	)
Convertible debt		(8,449	)		(16,003	)
Total deferred tax liabilities	$	(100,440	)	$	(261,503	)
Net deferred tax liability	$	(22,459	)	$	(88,407	)

Schedule of Reconciliation of Beginning and Ending Amounts of Unrecognized Tax Benefits

(In thousands)	Year ended December 31,         2017			Year ended December 31,         2016		Year ended December 31,         2015
Beginning of period balance	$	6,856		$	4,835	$	3,295
Increases for tax positions taken during a prior period		687			570		308
Decreases for tax positions taken during a prior period		(146	)		—		—
Increases for tax positions taken during the current period		—			1,451		1,232
Reduction as a result of a lapse of statute of limitations		—			—		—
	$	7,397		$	6,856	$	4,835