License, Research and Collaboration Agreements - Biogen Agreement - Additional Information (Details) - USD ($) $ in Millions	1 Months Ended	12 Months Ended
Oct. 31, 2022	Dec. 31, 2020
Biogen
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Additional payments based on the successful achievement of future regulatory or sales milestones		$ 300.0
Alkermes
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Licensing royalties, awarded amount	$ 18.3

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