Consolidated Statements of Cash Flows - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2022	Dec. 31, 2021
Cash flows from operating activities:
Net loss	$ (65,916)	$ (103,954)
Adjustments to reconcile net loss to net cash used in operating activities:
Share-based compensation expense	1,493	2,995
Amortization of debt discount and debt issuance costs	16,923	16,276
Depreciation and amortization expense	32,809	33,953
Change in contingent consideration obligation	(6,659)	2,895
Change in derivative liability	(37)	(1,156)
Gain on debt extinguishment	(27,142)
Non-cash royalty revenue	(4,762)	(12,106)
Deferred tax provision (benefit)	30,669	(5,186)
Changes in assets and liabilities:
Decrease in accounts receivable	2,585	3,191
Decrease (increase) in prepaid expenses and other current assets	(2,959)	8,419
Decrease in inventory	5,796	7,860
Increase in other assets	(237)	0
Increase (decrease) in accounts payable, accrued expenses and other current liabilities	(7,359)	1,108
Increase in other non-current liabilities	3,872	4,357
Net cash (used) in operating activities	(20,924)	(41,348)
Cash flows from investing activities:
Purchases of property and equipment	(136)	(165)
Purchases of intangible assets		(26)
Proceeds from sale of Chelsea facility, net		73,969
Net cash provided by investing activities	(136)	73,778
Cash flows from financing activities:
Repayment of Convertible Senior Notes Due 2021		(69,000)
Repayment of loans payable		(655)
Net cash (used) in financing activities		(69,655)
Effect of exchange rate changes on cash and cash equivalents and restricted cash	512	(447)
Net (decrease) in cash and cash equivalents and restricted cash	(20,548)	(37,672)
Cash, cash equivalents and restricted cash at beginning of period	65,223	102,895
Cash, cash equivalents and restricted cash at end of period	44,675	65,223
Supplemental disclosure:
Cash paid for interest	7,157	6
Cash paid for taxes	$ 199	$ 50