X0306 4 2019-07-23 0 0001585608 Jaguar Health, Inc. JAGX 0001008377 CONTE LISA A C/O JAGUAR HEALTH, INC. 201 MISSION STREET, SUITE 2375 SAN FRANCISCO CA 94105 1 1 0 0 CEO and President Bridge Warrant to Purchase Common Stock 2.00 2019-06-07 4 P 0 37500 A 2019-07-23 2024-06-07 Common Stock 37500 37500 D Stock Option (right to buy) 1.73 2019-07-24 4 A 0 1042052 0 A 2022-07-24 Common Stock 1042052 1042052 D The bridge warrant was issued pursuant to a purchase agreement dated June 7, 2019, but the exercise price was not determinable until the closing of the issuer's underwritten public offering on July 23, 2019. The bridge warrant is exercisable upon the consummation of such underwritten public offering for a period of five years from the date of issuance, unless earlier terminated upon occurrence of certain events as set forth in the terms of the warrant. The exercise price for the bridge warrant is $2.00, calculated as the per share price at which the issuer issued securities in the underwritten public offering. The reporting person purchased a 12% promissory notes and received a bridge warrant in connection therewith, which was exercisable for a number of shares of voting common stock equal to 75% of the principal amount of the promissory note divided by the exercise price of $2.00. Granted pursuant to the issuer's 2014 Equity Incentive Plan. The option grant was approved by the issuer's board of directors on July 19, 2019, subject to James J. Bochnowski, the chairman of the board of directors, and Karen S. Wright, the Chief Financial Officer of the issuer, determining the exact number of option shares to be granted per option based on the issuer's fully diluted shares outstanding following the issuer's underwritten public offering described in note 1 above. Mr. Bochnowski and Ms. Wright certified the exact number of option shares to be granted on 7/24/19, such that the effective date of the option grant was 7/24/19. Vests in equal monthly installments beginning on July 24, 2019, with five months of options, or 144,729 options, vested as of the grant date based on the reporting person's number of years of employment with the issuer, such that the grant is vested in full on the 3-year anniversary of the grant date. /s/ Lisa A. Conte 2019-07-25