X0306 4 2012-11-15 0 0001360886 OSIRIS THERAPEUTICS, INC. OSIR 0001008317 FRIEDLI PETER C/O OSIRIS THERAPEUTICS, INC. 7015 ALBERT EINSTEIN DRIVE COLUMBIA MD 21046 1 0 1 1 Chairman Common Stock 9616794 D Common Stock 2012-11-15 4 S 0 625 9.34 D 4656051 I See Note 2 Represents the sale of 625 shares of common stock by the Reporting Person's mother. The Reporting Person holds indirect beneficial ownership of 4,153,301 shares of common stock held by Venturetec, Inc., 500,000 shares held by his minor daughter and 2,750 shares held by his spouse. The Reporting Person holds approximately a 3% interest in Venturetec, Inc. and serves as its president. The Reporting Person disclaims beneficial ownership in the shares held by his daughter and spouse and disclaims beneficial interest in the shares held by Venturetec, Inc., beyond the extent of his pecuniary interest therein. Peter Friedli 2012-11-16