X0303 4 2011-02-14 0 0001360886 OSIRIS THERAPEUTICS, INC. OSIR 0001008317 FRIEDLI PETER C/O OSIRIS THERAPEUTICS, INC. 7015 ALBERT EINSTEIN DRIVE COLUMBIA MD 21046 1 0 1 1 Chairman Common Stock 2011-02-14 4 A 0 10000 7.13 A 10106794 D Common Stock 4156685 I See Note Grant of 10,000 shares of common stock of Osiris Therapeutics, Inc. as compensation for service as Chairman of the Registrant's Board of Directors during the fiscal year ended December 31, 2010, made under the Amended and Restated 2006 Omnibus Plan. The Reporting Person hold indirect beneficial ownership of 4,153,310 shares held by Venturetec, Inc., 2,750 shares held by his spouse and 625 shares held by his mother. The Reporting Person holds approximately a 3% interest in Venturetec, Inc. and serves as its president. The Reporting Person disclaims beneficial ownership in the shares held by his spouse and mother and disclaims beneficial interest in the shares held by Venturetec, Inc. beyond the extent of his pecuniary interest therein. Peter Friedli 2011-02-16