X0202 4 2008-02-04 0 0001360886 OSIRIS THERAPEUTICS, INC. OSIR 0001008317 FRIEDLI PETER C/O OSIRIS THERAPEUTICS, INC. 7015 ALBERT EINSTEIN DRIVE COLUMBIA MD 21046 1 0 1 1 Chairman Common Stock 2008-02-04 4 A 0 10000 12.01 A 4974245 I See Footnote Common Stock 2008-02-04 4 G 0 1000 12.01 D 9841630 D Common Stock 2008-02-04 4 J 0 29741 0 A 9870371 D Grant of 10,000 shares of common stock under the Registrant's 2006 Omnibus Plan for service as Chairman of the Board of Directors during 2007. These shares are owned by Joyce, Ltd., a non-U.S. corporation wholly owned by the Reporting Pereson. The Reporting Person holds indirect beneficial ownership of 625 shares held by his mother; 3,963,620 shares held by Venturetec, Inc.; 1,000,000 shares held by US Venture 05, Inc. and 10,000 shares owned by Joyce, Ltd. The Reporting Person holds approximately a 3% interest in Venturetec, INc. and serves as its president and holds 100% interest in and controls Joyce, Ltd. The Reporting Person disclaims beneficial interest in the shares held by his mother and disclaims beneficial interest in the shares held by Venturetec, Inc. and US Venture 05, Inc. beyond the extent of his pecuniary interest therein. Bona fide gift of shares to a minor residing outside of the U.S. The Reporting Person retains no beneficial ownership of the shares subject to the gift. Relects the distribution by Nikatech, Inc. to its equity holders of shares of the Registrant's common stock previously held by Nitatech, Inc., including an aggregate of 29, 741 shares distributed to the Reporting Person Philip R. Jacoby, Jr., attorney in fact 2008-02-06