X0202 4 2007-06-06 0 0001360886 OSIRIS THERAPEUTICS, INC. OSIR 0001008317 FRIEDLI PETER C/O OSIRIS THERAPEUTICS, INC. 7015 ALBERT EINSTEIN DRIVE COLUMBIA MD 21046 1 0 1 0 Common Stock 2007-06-06 4 P 0 1230229 11.38 A 9074884 D Common Stock 4869245 I See Footnote Convertible Promissory Note 18.00 2007-06-06 4 P 0 4000000 18.00 A 2007-02-09 2009-04-30 Common Stock 222222 1472222 D Shares acquired in a private placement under Regulation S of the Securities Act of 1933. The securities have not been registered under the United States Securities Act of 1933, as amended, or any state securities laws. Pursuant to the terms of the placement, the holders are provided demand registration rights for the purchased shares, but only after such time as the Issuer becomes eligible to effect such registration pursuant to a registration statement on Form S-3 or another "short-form" registration statement. The Reporting Person holds indirect beneficial ownership of 625 shares held by the Reporting Person's mother; 3,863,620 shares held by Venturetec, Inc.; 1,000,000 shares held by U S Venture 05, Inc.; and 5,000 shares held by Joyce Ltd. The Reporting Person holds approximately a 3% interest in Venturetec, Inc. and serves at its president; and holds 100% interest in and controls Joyce Ltd. The Reporting Person disclaims beneficial interest of the shares held by his mother and disclaims beneficial ownership of the shares held by Venturetec, Inc. and U S Venture 05, Inc. beyond the extent of his pecuniary interest therein. Represents the transfer and conveyence of the Convertible Promissory Note, dated October 30, 2006 of the Issuer in the original principal amount of $4,000,000 issued to Venturetec, Inc., who also is a Reporting Person of the Issuer, in a private transaction. Peter Friedli 2007-06-08