X0202 4 2007-05-11 0 0001360886 OSIRIS THERAPEUTICS, INC. OSIR 0001008317 FRIEDLI PETER C/O OSIRIS THERAPEUTICS, INC. 7015 ALBERT EINSTEIN DRIVE COLUMBIA MD 21046 1 0 1 0 Common Stock 2007-05-11 4 J 0 74744 0 A 7882018 D Common Stock 4713471 I See Footnote Reflects distribtuion by Nikatech, Inc. to its equity holders of shares of Osiris Common Stock previously held by Nikatech, including an aggregate of shares distributed to the Reporting Person. The Reporting Person holds approximately a 17% interest in Nikatech and serves as its investment manager. The Reporting Person held indirect beneficial ownership in 107,846 shares of Osiris Common Stock continuing to be owned by Nikatech; 625 shares held by the Reporting Person's mother; 3,600,000 shares held by Venturetec, Inc.; 1,000,000 shares held by U S Venture 05, Inc.; and 5,000 shares held by Joyce Ltd. The Reporting Person holds approximately a 17% interest in Nikatech and serves as its investment manager; holds approximately a 3% interest in Venturetec, Inc. and U S Venture 05, Inc. and serves as their president; and holds 100% interest in and controls Joyce Ltd. The Reporting Person disclaims beneficial interest of the shares held by his mother and disclaims beneficial ownership of the shares held by Nikatech, Inc., Venturetec, Inc. and U S Venture 05, Inc. beyond the extent of his pecuniary interest therein. Peter Friedli 2007-05-14