<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0202</schemaVersion>

    <documentType>4/A</documentType>

    <periodOfReport>2007-05-10</periodOfReport>

    <dateOfOriginalSubmission>2007-05-14</dateOfOriginalSubmission>

    <notSubjectToSection16>0</notSubjectToSection16>

    <issuer>
        <issuerCik>0001217688</issuerCik>
        <issuerName>FOXHOLLOW TECHNOLOGIES, INC.</issuerName>
        <issuerTradingSymbol>FOXH</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001007708</rptOwnerCik>
            <rptOwnerName>SIMPSON JOHN B PH D MD</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>C/O FOXHOLLOW TECHNOLOGIES, INC.</rptOwnerStreet1>
            <rptOwnerStreet2>740 BAY ROAD</rptOwnerStreet2>
            <rptOwnerCity>REDWOOD CITY</rptOwnerCity>
            <rptOwnerState>CA</rptOwnerState>
            <rptOwnerZipCode>94063</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>1</isDirector>
            <isOfficer>1</isOfficer>
            <isTenPercentOwner>1</isTenPercentOwner>
            <isOther>0</isOther>
            <officerTitle>Chief Executive Officer</officerTitle>
        </reportingOwnerRelationship>
    </reportingOwner>

    <nonDerivativeTable>
        <nonDerivativeHolding>
            <securityTitle>
                <value>Common Stock</value>
            </securityTitle>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>513190</value>
                    <footnoteId id="F1"/>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>I</value>
                    <footnoteId id="F2"/>
                </directOrIndirectOwnership>
                <natureOfOwnership>
                    <value>By JD Simpson Trust No. 2</value>
                </natureOfOwnership>
            </ownershipNature>
        </nonDerivativeHolding>
    </nonDerivativeTable>

    <footnotes>
        <footnote id="F1">Following all transactions reported on Dr. Simpson's Form 4 filed on May 14, 2007, Dr. Simpson indirectly holds an aggregate of 513,190 shares through the JD Simpson Trust No. 2.  In addition, following all transactions reported on Dr. Simpson's Form 4 filed on May 16, 2007, Dr. Simpson indirectly holds an aggregate of 509,590 shares through the JD Simpson Trust No. 2.  Dr. Simpson's Form 4s filed on such dates incorrectly report these share numbers.</footnote>
        <footnote id="F2">The shares are held in a trust for the benefit of Dr. Simpson's son of which Dr. Simpson serves as a trustee. Dr. Simpson disclaims beneficial ownership of these shares, and the filing of this report is not an admission that Dr. Simpson is a beneficial owner of these shares for purposes of Section 16 or for any other purpose.</footnote>
    </footnotes>

    <ownerSignature>
        <signatureName>/s/ Matthew B. Ferguson, as Attorney-in-Fact</signatureName>
        <signatureDate>2007-06-13</signatureDate>
    </ownerSignature>
</ownershipDocument>
