<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0202</schemaVersion>

    <documentType>4/A</documentType>

    <periodOfReport>2005-05-31</periodOfReport>

    <dateOfOriginalSubmission>2005-06-02</dateOfOriginalSubmission>

    <notSubjectToSection16>0</notSubjectToSection16>

    <issuer>
        <issuerCik>0001217688</issuerCik>
        <issuerName>FOXHOLLOW TECHNOLOGIES, INC.</issuerName>
        <issuerTradingSymbol>FOXH</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001007708</rptOwnerCik>
            <rptOwnerName>SIMPSON JOHN B PH D MD</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>C/O FOXHOLLOW TECHNOLOGIES, INC.</rptOwnerStreet1>
            <rptOwnerStreet2>740 BAY ROAD</rptOwnerStreet2>
            <rptOwnerCity>REDWOOD CITY</rptOwnerCity>
            <rptOwnerState>CA</rptOwnerState>
            <rptOwnerZipCode>94063</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>1</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>1</isTenPercentOwner>
            <isOther>0</isOther>
        </reportingOwnerRelationship>
    </reportingOwner>

    <nonDerivativeTable>
        <nonDerivativeHolding>
            <securityTitle>
                <value>Common Stock</value>
            </securityTitle>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>539590</value>
                    <footnoteId id="F1"/>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>I</value>
                    <footnoteId id="F2"/>
                </directOrIndirectOwnership>
                <natureOfOwnership>
                    <value>By JD Simpson Trust</value>
                </natureOfOwnership>
            </ownershipNature>
        </nonDerivativeHolding>
    </nonDerivativeTable>

    <footnotes>
        <footnote id="F1">Includes 12,863 shares received through a pro rata distribution from De Novo (Q) Ventures I, L.P., which were omitted from Dr. Simpson's Forms 4 filed with the Securities and Exchange Commission on and after June 2, 2005.</footnote>
        <footnote id="F2">The shares are held in a trust for the benefit of Dr. Simpson's son of which Dr. Simpson serves as a trustee. Dr. Simpson disclaims beneficial ownership of these shares, and the filing of this report is not an admission that Dr. Simpson is a beneficial owner of these shares for purposes of Section 16 or for any other purpose.</footnote>
    </footnotes>

    <ownerSignature>
        <signatureName>/s/ John B. Simpson</signatureName>
        <signatureDate>2005-12-02</signatureDate>
    </ownerSignature>
</ownershipDocument>
