<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/schedule13g" xmlns:com="http://www.sec.gov/edgar/common">
  <schemaVersion>X0202</schemaVersion>
<headerData>
    <submissionType>SCHEDULE 13G</submissionType>
    <filerInfo>
      <filer>
        <filerCredentials>
          <cik>0002086358</cik>
          <ccc>XXXXXXXX</ccc>
        </filerCredentials>
      </filer>
      <liveTestFlag>LIVE</liveTestFlag>


    </filerInfo>
  </headerData>
  <formData>
    <coverPageHeader>
      <securitiesClassTitle>Common Shares</securitiesClassTitle>
      <eventDateRequiresFilingThisStatement>10/14/2026</eventDateRequiresFilingThisStatement>
      <issuerInfo>
        <issuerCik>0001006281</issuerCik>
        <issuerName>Protalix BioTherapeutics, Inc.</issuerName>
        <issuerCusips>
          <issuerCusipNumber>74365A309</issuerCusipNumber>
        </issuerCusips>
        <issuerPrincipalExecutiveOfficeAddress>
          <com:street1>2 UNIVERSITY PLAZA</com:street1>
          <com:street2>SUITE 100</com:street2>
          <com:city>HACKENSACK</com:city>
          <com:stateOrCountry>NJ</com:stateOrCountry>
          <com:zipCode>07601</com:zipCode>
        </issuerPrincipalExecutiveOfficeAddress>
      </issuerInfo>
    </coverPageHeader>
    <coverPageHeaderReportingPersonDetails>

      <reportingPersonName>HOLD Alapkezelo Zrt.</reportingPersonName>
      <citizenshipOrOrganization>K5</citizenshipOrOrganization>
      <reportingPersonBeneficiallyOwnedNumberOfShares>
        <soleVotingPower>4157791.00</soleVotingPower>
        <sharedVotingPower>0.00</sharedVotingPower>
        <soleDispositivePower>4157791.00</soleDispositivePower>
        <sharedDispositivePower>0.00</sharedDispositivePower>
      </reportingPersonBeneficiallyOwnedNumberOfShares>
      <reportingPersonBeneficiallyOwnedAggregateNumberOfShares>4157791.00</reportingPersonBeneficiallyOwnedAggregateNumberOfShares>
      <classPercent>5.2</classPercent>
      <typeOfReportingPerson>OO</typeOfReportingPerson>
      <comments>Hungarian investment fund management company.</comments>
    </coverPageHeaderReportingPersonDetails>
    <items>
      <item1>
        <issuerName>Protalix BioTherapeutics, Inc.</issuerName>
        <issuerPrincipalExecutiveOfficeAddress>2 UNIVERSITY PLAZA, SUITE 100, HACKENSACK, NEW JERSEY, 07601</issuerPrincipalExecutiveOfficeAddress>
      </item1>
      <item2>
        <filingPersonName>HOLD Alapkezelo Zrt. (HUNGARY)</filingPersonName>
        <principalBusinessOfficeOrResidenceAddress>H-1123 Budapest, Alkotas u. 50., Hungary</principalBusinessOfficeOrResidenceAddress>
        <citizenship>Hungarian</citizenship>
      </item2>
      <item3>
        <notApplicableFlag>Y</notApplicableFlag>
      </item3>
      <item4>
        <amountBeneficiallyOwned>Based upon 80,571,642  shares of the Issuers common stock outstanding as of June 30, 2026, in accordance with 10-Q filed on August 1, 2026.HOLD Alapkezelo Zrt. may have been deemed to have the beneficial ownership of 4,157,791 shares of common stock representing the beneficial ownership of approximately 5.16% of the common stocks.</amountBeneficiallyOwned>
        <classPercent>5.2%</classPercent>
        <numberOfSharesPersonHas>
          <solePowerOrDirectToVote>HOLD Alapkezelo Zrt.:4,157,791 shares of Common Stock</solePowerOrDirectToVote>
          <sharedPowerOrDirectToVote>0</sharedPowerOrDirectToVote>
          <solePowerOrDirectToDispose>HOLD Alapkezelo Zrt.:4,157,791 shares of Common Stock</solePowerOrDirectToDispose>
          <sharedPowerOrDirectToDispose>0</sharedPowerOrDirectToDispose>
        </numberOfSharesPersonHas>
      </item4>
      <item5>
        <notApplicableFlag>Y</notApplicableFlag>
        <classOwnership5PercentOrLess>N</classOwnership5PercentOrLess>
      </item5>
      <item6>
        <notApplicableFlag>Y</notApplicableFlag>
      </item6>
      <item7>
        <notApplicableFlag>Y</notApplicableFlag>
      </item7>
      <item8>
        <notApplicableFlag>Y</notApplicableFlag>
      </item8>
      <item9>
        <notApplicableFlag>Y</notApplicableFlag>
      </item9>
      <item10>
        <notApplicableFlag>N</notApplicableFlag>
        <certifications>By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect, other than activities solely in connection with a nomination under &amp;#167; 240.14a-11.

</certifications>
      </item10>
    </items>
    <signatureInformation>
      <reportingPersonName>HOLD Alapkezelo Zrt.</reportingPersonName>
      <signatureDetails>
        <signature>David Pekar</signature>
        <title>Chief Investment Officer</title>
        <date>10/15/2026</date>
      </signatureDetails>
    </signatureInformation>
  </formData>
</edgarSubmission>
