Document and Entity Information - shares	9 Months Ended
	Sep. 30, 2020	Oct. 15, 2020
Document and Entity Information
Document Type	10-Q
Document Quarterly Report	true
Document Transition Report	false
Document Period End Date	Sep. 30, 2020
Entity File Number	001-33357
Entity Registrant Name	PROTALIX BIOTHERAPEUTICS, INC.
Entity Incorporation, State or Country Code	DE
Entity Tax Identification Number	65-0643773
Entity Address, Address Line One	2 Snunit Street
Entity Address, Address Line Two	Science Park
Entity Address, Address Line Three	POB 455
Entity Address, City or Town	Carmiel
Entity Address, Country	IL
Entity Address, Postal Zip Code	2161401
City Area Code	972-4
Local Phone Number	988-9488
Title of 12(b) Security	Common stock, par value $0.001 par value,
Trading Symbol	PLX
Security Exchange Name	NYSEAMER
Entity Current Reporting Status	Yes
Entity Interactive Data Current	Yes
Entity Filer Category	Accelerated Filer
Entity Small Business	true
Entity Emerging Growth Company	false
Entity Shell Company	false
Entity Common Stock, Shares Outstanding		33,336,709
Entity Central Index Key	0001006281
Current Fiscal Year End Date	--12-31
Document Fiscal Year Focus	2020
Document Fiscal Period Focus	Q3
Amendment Flag	false