SCHEDULE 13G 0001426156 XXXXXXXX LIVE Common Stock, $0.001 par value per share 02/26/2026 0001006281 Protalix BioTherapeutics, Inc. 74365A309 2 UNIVERSITY PLAZA SUITE 100 HACKENSACK NJ 07601 Rule 13d-1(c) MAK Capital Fund LP a D0 0.00 4649599.00 0.00 4649599.00 4649599.00 5.8 PN The calculation is based upon 4,649,599 shares beneficially owned as of 03/04/2026 and 80,421,181 total shares of Common Stock outstanding as of November 1, 2025, as reported by the Issuer in its Form 10-Q filed November 13, 2025. MAK CAPITAL ONE LLC a DE 0.00 4649599.00 0.00 4649599.00 4649599.00 5.8 IA The calculation is based upon 4,649,599 shares beneficially owned as of 03/04/2026 and 80,421,181 total shares of Common Stock outstanding as of November 1, 2025, as reported by the Issuer in its Form 10-Q filed November 13, 2025. Kaufman Michael A a X1 0.00 4649599.00 0.00 4649599.00 4649599.00 5.8 IN The calculation is based upon 4,649,599 shares beneficially owned as of 03/04/2026 and 80,421,181 total shares of Common Stock outstanding as of November 1, 2025, as reported by the Issuer in its Form 10-Q filed November 13, 2025. Protalix BioTherapeutics, Inc. 2 UNIVERSITY PLAZA, SUITE 100, HACKENSACK, NEW JERSEY, 07601. This Schedule 13G is being filed by: i. MAK Capital Fund LP ("MAK Fund") ii. MAK Capital One L.L.C. ("MAK Capital"); and iii. Michael A. Kaufman ("Mr. Kaufman," and collectively with MAK Fund and MAK Capital, the "Reporting Persons") The principal business address of (i) MAK Fund is c/o Wakefield Quin, Victoria Place, 31 Victoria Street, Bermuda; and (ii) MAK Capital and Mr. Kaufman is 590 Madison Avenue, 31st Floor, New York, NY 10022. MAK Capital Fund LP is a Bermuda limited partnership. MAK Capital One L.L.C. is a Delaware limited liability company. Mr. Kaufman is a United States citizen. Y 4,649,599 5.8% The calculation is based upon 4,649,599 shares of Common Stock beneficially owned as of 03/04/2026 and 80,421,181 total shares of Common Stock, $0.001 par value per share, outstanding as of November 1, 2025, as reported by the Issuer in its Form 10-Q filed November 13, 2025. 0 4,649,599 0 4,649,599 Y N Y Y Y Y N By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect, other than activities solely in connection with a nomination under § 240.14a-11. MAK Capital Fund LP /s/ Michael A. Kaufman 03/04/2026 MAK CAPITAL ONE LLC /s/ Michael A. Kaufman 03/04/2026 Kaufman Michael A /s/ Michael A. Kaufman 03/04/2026