X0306 4 2017-11-30 0 0001616543 Senseonics Holdings, Inc. SENS 0001005561 BARRIS PETER J 1954 GREENSPRING DRIVE SUITE 600 TIMONIUM MD 21093 0 0 1 0 Common Stock 2017-11-30 4 J 0 2534912 0.00 D 0 I See Note 2 Common Stock 2017-11-30 4 J 0 652090 0.00 A 652090 I See Note 4 Common Stock 2017-11-30 4 J 0 652090 0.00 D 0 I See Note 4 Common Stock 2017-11-30 4 J 0 48377 0.00 A 48377 D Common Stock 21911183 I See Note 7 Common Stock 8949292 I See Note 8 Common Stock 27791 I See Note 9 New Enterprise Associates VII, Limited Partnership ("NEA VII") made a pro rata distribution for no consideration of an aggregate of 2,534,912 shares of common stock of the Issuer to its general partner and its limited partners on November 30, 2017. The Reporting Person is the sole general partner of NEA Partners VII, Limited Partnership ("NEA Partners VII"). NEA Partners VII is the sole general partner of NEA VII, the direct beneficial owner of the securities. The Reporting Person disclaims beneficial ownership within the meaning of Section 16 of the Securities Exchange Act of 1934, as amended, or otherwise of such portion of the NEA VII shares in which the Reporting Person has no pecuniary interest. NEA Partners VII received 652,090 shares of common stock of the Issuer in the distribution by NEA VII on November 30, 2017. The Reporting Person is the sole general partner of NEA Partners VII, the direct beneficial owner of the securities. The Reporting Person disclaims beneficial ownership within the meaning of Section 16 of the Securities Exchange Act of 1934, as amended, or otherwise of such portion of the securities of the Issuer held by NEA Partners VII in which the Reporting Person has no pecuniary interest. NEA Partners VII made a pro rata distribution for no consideration of an aggregate of 652,090 shares of common stock of the Issuer to its general partners and limited partners on November 30, 3017. The Reporting Person received 48,377 shares of common stock of the Issuer in the distribution by NEA Partners VII on November 30, 2017. The Reporting Person is a general partner of NEA Partners 10, Limited Partnership ("NEA Partners 10"). NEA Partners 10 is the sole general partner of New Enterprise Associates 10, Limited Partnership ("NEA 10"), the direct beneficial owner of the securities. The Reporting Person disclaims beneficial ownership within the meaning of Section 16 of the Securities Exchange Act of 1934, as amended, or otherwise of such portion of the NEA 10 shares in which the Reporting Person has no pecuniary interest. The Reporting Person is the sole general partner of NEA Partners 9, Limited Partnership ("NEA Partners 9"). NEA Partners 9 is the sole general partner of New Enterprise Associates 9, Limited Partnership ("NEA 9"), the direct beneficial owner of the securities. The Reporting Person disclaims beneficial ownership within the meaning of Section 16 of the Securities Exchange Act of 1934, as amended, or otherwise of such portion of the NEA 9 shares in which the Reporting Person has no pecuniary interest. The Reporting Person is the sole general partner of NEA General Partners, L.P. NEA General Partners, L.P. is the sole general partner of NEA Presidents' Fund, L.P. ("NEA Presidents' Fund"), the direct beneficial owner of the securities. The Reporting Person disclaims beneficial ownership within the meaning of Section 16 of the Securities Exchange Act of 1934, as amended, or otherwise of such portion of the NEA Presidents' Fund shares in which the Reporting Person has no pecuniary interest. /s/ Sasha Keough, attorney-in-fact 2017-12-04