144 0001005544 XXXXXXXX LIVE 0001356576 SUPERNUS PHARMACEUTICALS, INC. 001-35518 9715 Key West Avenue Rockville MD 20850 301-838-2500 CHARLES NEWHALL Officer Common Morgan Stanley Smith Barney LLC Executive Financial Services

1 New York Plaza 8th Floor New York NY 10004

10700 387775.49 55219273 11/11/2024 NASDAQ Common 11/11/2024 Exercise of options under a registered plan Issuer N 10700 11/11/2024 Cash Y Sales that were executed on November 11, 2024 are being reported on this Form 144 filed on November 12, 2024 given the EDGAR system was not accepting filings on November 11, 2024 in observance of the federal holiday. 11/11/2024 /s/ Charles Newhall