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CONSOLIDATED STATEMENTS OF CASH FLOWS (UNAUDITED) (USD $)
9 Months Ended
Sep. 30, 2011
Sep. 30, 2010
CASH FLOWS FROM OPERATING ACTIVITIES:  
Net loss$ (2,578,730)$ (14,600,996)
Adjustments to reconcile net loss to net cash provided by (used in) operating activities:  
Amortization of deferred revenue(2,234,413)(3,653,330)
Depreciation1,092,3051,329,279
Amortization of intangibles34,1941,234,272
Amortization of premium and discount on investments, net(483,288)(121,891)
Stock-based employee compensation3,270,2861,902,701
Stock-based non-employee compensation2,89943,308
Non-cash expense under a materials agreement9,181896,184
Stock-based compensation to Board of Directors and Scientific Advisory Board1,252,275660,983
Loss on stock warrant liability4,190,2835,231,626
Retirement plan benefit expense1,145,154684,164
Decrease (increase) in assets:  
Accounts receivable(4,513,407)(1,352,085)
Inventory(2,228,411)(1,568)
Other current assets270,851(211,372)
Other assets(95,855)(38,835)
Increase in liabilities:  
Accounts payable and accrued expenses5,306,8272,335,190
Deferred revenue3,330,000688,623
Other current liabilities24,546 
Net cash provided by (used in) operating activities7,794,697(4,973,747)
CASH FLOWS FROM INVESTING ACTIVITIES:  
Purchase of property and equipment(2,208,403)(218,609)
Purchase of intangibles(439,644) 
Purchase of short-term investments(290,269,260)(71,972,672)
Proceeds from sale of short-term investments72,726,65456,454,984
Net cash used in investing activities(220,190,653)(15,736,297)
CASH FLOWS FROM FINANCING ACTIVITIES:  
Proceeds from the issuance of common stock249,867,265191,618
Proceeds from the exercise of common stock options and warrants13,282,7977,167,562
Payment of withholding taxes related to stock-based employee compensation(3,998,516)(1,147,522)
Net cash provided by financing activities259,151,5466,211,658
INCREASE (DECREASE) IN CASH AND CASH EQUIVALENTS46,755,590(14,498,386)
CASH AND CASH EQUIVALENTS, BEGINNING OF PERIOD20,368,85222,701,126
CASH AND CASH EQUIVALENTS, END OF PERIOD67,124,4428,202,740
The following non-cash activities occurred:  
Unrealized gain (loss) on available-for-sale securities8,733(8,072)
Common stock issued to Board of Directors and Scientific Advisory Board that was earned in a previous period299,943314,181
Common stock issued to employees that was accrued for in a previous period, net of shares withheld for taxes1,113,483929,552
Common stock issued for royalties that was earned in a previous period 81,273
Fair value of stock warrant liability reclassified to shareholders' equity upon exercise$ 14,850,038