CONSOLIDATED STATEMENTS OF INCOME - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2022	Dec. 31, 2021	Dec. 31, 2020
REVENUE:
Total revenue	$ 616,619	$ 553,525	$ 428,867
COST OF SALES	127,896	114,991	85,478
Gross margin	488,723	438,534	343,389
OPERATING EXPENSES:
Research and development	117,062	99,673	83,894
Selling, general and administrative	77,886	80,372	61,346
Amortization of acquired technology and other intangible assets	17,459	21,994	21,969
Patent costs	8,329	8,160	7,529
Royalty and license expense	877	691	11,125
Total operating expenses	221,613	210,890	185,863
OPERATING INCOME	267,110	227,644	157,526
Interest income, net	7,811	505	5,139
Other (loss) income, net	(6,691)	98	864
Interest and other income, net	1,120	603	6,003
INCOME BEFORE INCOME TAXES	268,230	228,247	163,529
INCOME TAX EXPENSE	(58,169)	(44,034)	(30,157)
NET INCOME	$ 210,061	$ 184,213	$ 133,372
NET INCOME PER COMMON SHARE:
BASIC	$ 4.41	$ 3.87	$ 2.80
DILUTED	$ 4.40	$ 3.87	$ 2.80
WEIGHTED AVERAGE SHARES USED IN COMPUTING NET INCOME PER COMMON SHARE:
BASIC	47,390,352	47,296,447	47,198,982
DILUTED	47,468,507	47,365,435	47,236,994
CASH DIVIDEND DECLARED PER COMMON SHARE	$ 1.20	$ 0.80	$ 0.60
Material sales
REVENUE:
Total revenue	$ 331,081	$ 318,623	$ 229,749
Royalty and license fees
REVENUE:
Total revenue	267,115	219,032	185,054
Contract research services
REVENUE:
Total revenue	$ 18,423	$ 15,870	$ 14,064