CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($) $ in Thousands	3 Months Ended
	Mar. 31, 2017	Mar. 31, 2016
Operating Activities
Net loss	$ (26,741)	$ (20,917)
Adjustments for non-cash items:
Depreciation and amortization	26,349	27,668
Accretion of debt discount and debt issuance costs	4,650	4,235
Provision for inventory obsolescence	201	401
Gain on disposal of property and equipment	(50)
Stock-based compensation	3,556	3,910
Change in fair value of contingent consideration	(5,301)	153
Deferred income taxes		(6,384)
Other	192	470
Changes in assets and liabilities:
Accounts receivable	34,539	1,225
Receivables from collaborative partners	236	(289)
Inventories	873	(761)
Prepaid and other assets	703	(1,497)
Accounts payable and other accrued liabilities	(17,833)	(22,938)
Accrued rebates, returns and discounts	(2,970)	975
Interest payable	(2,440)	(2,328)
Income taxes payable	42
Net cash provided by (used in) operating activities	16,006	(16,077)
Investing Activities
Purchases of property and equipment	(470)	(45)
Proceeds from disposal of property and equipment	50
Purchases of marketable securities		(5,988)
Maturities of marketable securities	52,831	101,876
Net cash provided by investing activities	52,411	95,843
Financing Activities
Payment of contingent consideration liability	(913)	(260)
Proceeds from issuance of common stock	2,597	1,383
Net cash provided by financing activities	1,684	1,123
Net increase in cash and cash equivalents	70,101	80,889
Cash and cash equivalents at beginning of year	117,709	101,084
Cash and cash equivalents at end of period	187,810	181,973
Supplemental Disclosure of Cash Flow Information
Cash paid for interest	17,362	20,109
Capitalized expenditures incurred but not yet paid	$ 123	$ 865