CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($) $ in Thousands	9 Months Ended
	Sep. 30, 2016	Sep. 30, 2015
Operating Activities
Net loss	$ (44,352)	$ (45,070)
Adjustments for non-cash items:
Depreciation and amortization	83,019	57,930
Accretion of debt discount and debt issuance costs	13,084	11,456
Loss on prepayment of Senior Notes	5,777
Provision for inventory obsolescence	754	1,159
Loss on disposal of property and equipment		45
Stock-based compensation	12,602	9,697
Change in fair value of contingent consideration and unfavorable contract	(22)	(2,733)
Deferred income taxes	(18,193)	(13,238)
Excess tax benefit from stock-based compensation	(984)	(4,011)
Other	617	391
Changes in assets and liabilities:
Accounts receivable	(15,833)	(41,352)
Receivables from collaborative partners	134	181
Inventories	(1,519)	7,533
Prepaid and other assets	(987)	(2,208)
Income taxes receivable	(8,147)	(15,598)
Accounts payable and other accrued liabilities	6,890	107,821
Interest payable	(4,903)	13,836
Net cash provided by operating activities	27,937	85,839
Investing Activities
Purchases of property and equipment	(2,786)	(1,162)
Acquisition of business		(1,050,000)
Purchases of marketable securities	(48,861)	(62,153)
Maturities of marketable securities	108,207	72,505
Sales of marketable securities	2,007
Net cash provided by (used in) investing activities	58,567	(1,040,810)
Financing Activities
Proceeds from the issuance of Senior Notes		562,063
Senior Notes issuance costs		(511)
Repayment of Senior Notes	(100,000)
Repayment fees for repayment of Senior Notes	(5,000)
Proceeds from issuance of common stock	6,785	8,240
Excess tax benefit from stock-based compensation	984	4,011
Net cash (used in) provided by financing activities	(97,231)	573,803
Net decrease in cash and cash equivalents	(10,727)	(381,168)
Cash and cash equivalents at beginning of year	101,084	488,668
Cash and cash equivalents at end of period	90,357	107,500
Supplemental Disclosure of Cash Flow Information
Net cash paid for income taxes	83	77
Cash paid for interest	53,043	$ 23,715
Capitalized expenditures incurred but not yet paid	$ 392