CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($) $ in Thousands	6 Months Ended
	Jun. 30, 2016	Jun. 30, 2015
Operating Activities
Net loss	$ (31,458)	$ (33,286)
Adjustments for non-cash items:
Depreciation and amortization	55,336	30,292
Accretion of debt discount and debt issuance costs	8,624	7,387
Loss on prepayment of Senior Notes	5,777
Provision for inventory obsolescence	403	514
Loss on disposal of property and equipment		45
Stock-based compensation	8,238	6,066
Change in fair value of contingent consideration and unfavorable contract	(73)	(2,214)
Deferred income taxes	(12,599)	(11,337)
Excess tax benefit from stock-based compensation	(436)	(2,273)
Other	472	277
Changes in assets and liabilities:
Accounts receivable	(8,354)	(32,743)
Receivables from collaborative partners	67	322
Inventories	(346)	9,156
Prepaid and other assets	(4,912)	(2,256)
Income taxes receivable		(9,861)
Accounts payable and other accrued liabilities	(6,311)	58,831
Interest payable	(2,889)	18,160
Net cash provided by operating activities	11,539	37,080
Investing Activities
Purchases of property and equipment	(2,538)	(1,134)
Acquisition of business		(1,050,000)
Purchases of marketable securities	(26,570)	(18,108)
Maturities of marketable securities	103,707	67,105
Net cash provided by (used in) investing activities	74,599	(1,002,137)
Financing Activities
Proceeds from the issuance of Senior Notes		562,063
Senior Notes issuance costs		(511)
Repayment of Senior Notes	(100,000)
Repayment fees for repayment of Senior Notes	(5,000)
Proceeds from issuance of common stock	5,163	6,658
Excess tax benefit from stock-based compensation	436	2,273
Net cash (used in) provided by financing activities	(99,401)	570,483
Net decrease in cash and cash equivalents	(13,263)	(394,574)
Cash and cash equivalents at beginning of year	101,084	488,668
Cash and cash equivalents at end of period	87,821	94,094
Supplemental Disclosure of Cash Flow Information
Net cash paid for income taxes	78	40
Cash paid for interest	35,823	4,121
Capitalized expenditures incurred but not yet paid	$ 124	$ 437