As filed with the Securities and Exchange Commission on February 18, 2022

File No. 033-65137

File No. 811-07455

SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549

FORM N-1A

REGISTRATION STATEMENT

Under the SECURITIES ACT OF 1933	¨
Pre-Effective Amendment No.	¨
Post-Effective Amendment No. 124	x

and/or

REGISTRATION STATEMENT

Under the INVESTMENT COMPANY ACT OF 1940	¨
Amendment No. 125	x

(Check appropriate box or boxes)

Virtus Opportunities Trust

(Exact Name of Registrant as Specified in Charter)

Area Code and Telephone Number: (800) 243-1574

101 Munson Street

Greenfield, Massachusetts 01301

(Address of Principal Executive Offices)

Kevin J. Carr, Esq.

Vice President and Senior Counsel

Virtus Investment Partners, Inc.

One Financial Plaza

Hartford, Connecticut 06103

(Name and Address of Agent for Service)

Copies of All Correspondence to:

David C. Mahaffey, Esq. Sullivan & Worcester LLP 1666 K Street, N.W. Washington, D.C. 20006 and Paul J. Delligatti, Esq. Goodwin Procter LLP 1900 N Street, N.W. Washington, DC 20036

It is proposed that this filing will become effective (check appropriate box):

¨ immediately upon filing pursuant to paragraph (b)

x on March 20, 2022 pursuant to paragraph (b) of Rule 485

¨ 60 days after filing pursuant to paragraph (a)(1)

¨ on __________ or at such later date as the Commission shall order pursuant to paragraph (a)(2)

¨ 75 days after filing pursuant to paragraph (a)(2)

¨ on __________ pursuant to paragraph (a)(2) of Rule 485.

If appropriate, check the following box:

x this post-effective amendment designates a new effective date for a previously filed post-effective amendment.

This Post-Effective Amendment consists of the following:

1. Facing Sheet of the Registration Statement

2. Signature Page

This filing incorporates by reference Parts A, B and C of Registrant’s Post-Effective Amendment No. 122 filed with the Securities and Exchange Commission on December 6, 2021 as Accession No. 0001104659-21-146835. This Post-Effective Amendment No. 124 is being filed for the sole purpose of delaying the effectiveness of the above-referenced Amendment to March 20, 2022.

SIGNATURES

Pursuant to the requirements of the Securities Act of 1933, as amended, and the Investment Company Act of 1940, as amended, the Registrant certifies that it meets all of the requirements for effectiveness for this registration statement under Rule 485(b) of the Securities Act and has duly caused this amendment to the registration statement to be signed on its behalf by the undersigned, duly authorized, in the City of Hartford and the State of Connecticut on the 18^th day of February, 2022.

VIRTUS OPPORTUNITIES TRUST
By:	/s/ George R. Aylward
	George R. Aylward
	President

Pursuant to the requirements of the Securities Act of 1933, as amended, this amendment to the registration statement has been signed below by the following persons in the capacities indicated on the 18^th day of February, 2022.

Signature	Title
/s/ George R. Aylward	Trustee and President
George R. Aylward	(principal executive officer)
/s/ W. Patrick Bradley	Chief Financial Officer and Treasurer
W. Patrick Bradley	(principal financial and accounting officer)
*	Trustee
Donald C. Burke
*	Trustee
Sidney E. Harris
*	Trustee
John R. Mallin
*	Trustee
Connie D. McDaniel
*	Trustee and Chairman
Philip R. McLoughlin
*	Trustee
Geraldine M. McNamara
*	Trustee
R. Keith Walton
*	Trustee
Brian T. Zino

*By:	/s/ George R. Aylward
	*George R. Aylward, Attorney-in-Fact, pursuant to a power of attorney