One Financial Plaza, Hartford, CT 06103 | 800.248.7971 | Virtus.com

September 28, 2021

VIA EDGAR

Securities and Exchange Commission

Division of Investment Management

100 F Street, N.E.

Washington, DC 20549

RE: Virtus Opportunities Trust

1933 Act/Rule 497(j)

File Nos. 033-65137 and 811-07455

Post-Effective Amendment No. 121

To The Commission Staff:

In accordance with Rule 497(j) of the Securities Act of 1933, as amended, the undersigned certifies that the Prospectus for Virtus KAR International Small-Mid Cap Fund, and the Statement of Additional Information for Virtus Opportunities Trust, that would have been filed under Rule 497(c) did not differ from those contained in the most recent registration statement for such registrant, filed electronically on September 24, 2021.

Please contact Holly van den Toorn at 404-845-7679 or the undersigned at (860) 263-4790 if you have any questions concerning this amendment.

Very truly yours,

/s/ Jennifer Fromm

Jennifer Fromm

Vice President,

Chief Legal Officer,

Counsel and Secretary

Virtus Mutual Funds

cc: Ralph Summa

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