Note 13 - Share-Based Compensation (Tables)

3 Months Ended

Mar. 31, 2013

Schedule of Employee Service Share-based Compensation, Allocation of Recognized Period Costs [Table Text Block]

	Three Months Ended March 31,
(in $000’s)	2013		2012
Manufacturing expenses	$	673	$	637
Research and development		1,376		1,213
Selling, general and administrative		2,310		1,959
Total	$	4,359	$	3,809

Schedule of Share-based Compensation, Stock Options, Activity [Table Text Block]

	Number of Shares Under Option			Weighted Average Exercise Price per Share
Outstanding at December 31, 2012		4,177,221		$	12.72
Options granted		--		$	--
Options exercised		(212,115	)	$	6.37
Options forfeited		(7,880	)	$	14.40
Outstanding at March 31, 2013		3,957,226		$	13.06
Options exercisable at March 31, 2013		3,028,925		$	11.43

Schedule of Share-based Compensation, Restricted Stock and Restricted Stock Units Activity [Table Text Block]

Restricted Stock Awards	Number of Restricted Stock Awards			Weighted Average Grant-Date Fair Value
Non-vested at December 31, 2012		1,954,570		$	20.97
Granted		41,675		$	21.23
Vested		(58,429	)	$	10.49
Forfeited		(22,201	)	$	20.56
Non-vested at March 31, 2013		1,915,615		$	21.31