X0202 4 2007-08-09 0001003124 PHARMACEUTICAL PRODUCT DEVELOPMENT INC PPDI 0001180469 MARIO ERNEST 20 GREENHOUSE DRIVE PRINCETON NJ 08540 1 0 0 0 Common Stock 2007-08-09 4 M 0 16000 5.97 A 450669 D Commons Stock 2007-08-09 4 S 0 5000 38.71 D 445669 D Commons Stock 2007-08-09 4 S 0 5000 38.69 D 440669 D Commons Stock 2007-08-09 4 S 0 6000 38.68 D 434669 D Common Stock 341062 I By Spouse Common Stock 18500 I By Trust Common Stock 18500 I By Trust Stock Options (to buy) 5.97 2007-08-09 4 M 0 16000 0 D 1998-05-13 2008-05-12 Common Stock 16000 0 D Stock Options (to buy) 6.25 1999-05-12 2009-05-11 Common Stock 16000 16000 D Stock Options (to buy) 15.82 2001-05-15 2011-05-14 Common Stock 8000 8000 D Stock Options (to buy) 12.81 2002-05-15 2012-05-14 Common Stock 12000 12000 D Stock Options (to buy) 13.58 2003-05-14 2013-05-13 Common Stock 16000 16000 D Stock Options (to buy) 15.06 2004-05-19 2014-05-18 Common Stock 16000 16000 D Stock Options (to buy) 23.79 2005-05-18 2015-05-17 Common Stock 5458 5458 D Stock Options (to buy) 35.38 2006-05-17 2016-05-16 Common Stock 3973 3973 D Stock Options (to buy) 33.82 2007-05-16 2017-05-15 Common Stock 6126 6126 D Lisa C. Noecker attorney-in-fact for Ernest Mario 2007-08-10