X0202 4/A 2005-09-15 2005-09-19 0001002637 MILLENNIUM PHARMACEUTICALS INC MLNM 0001192595 TEPPER ROBERT I MILLENNIUM PHARMACEUTICALS, INC. 40 LANDSDOWNE STREET CAMBRIDGE MA 02139 0 1 0 0 President, R&D Common stock 2005-09-15 4 A 0 45000 0 A 65671 D Common stock 333 I by son Common stock 333 I by son Common stock 4338 I by 401(k) plan account Reflects a grant of restricted stock under the 2000 Stock Incentive Plan which vests under the terms of the Restricted Stock Agreement between the Company and Dr. Tepper dated September 15, 2005. On March 3, 2006, the Company amended the Restricted Stock Agreement with Dr. Tepper to change the vesting dates. Under the new vesting schedule, if Dr. Tepper remains an employee of the Company, 50% of the shares will vest on 09/15/2006 and 50% of the shares will vest on 09/15/2007. Includes 2,556 shares acquired on 04/29/2005 under Millennium's Employee Stock Purchase Plan. Held by custodian for son, Edward Tepper, under the Uniform Gifts to Minors Act. Dr. Tepper disclaims beneficial ownership of these shares. Held by custodian for son, James Tepper, under the Uniform Gifts to Minors Act. Dr. Tepper disclaims beneficial ownership of these shares. Joel S. Goldberg, Attorney-In-Fact 2006-03-07