0001193125-23-044824.txt : 20230222 0001193125-23-044824.hdr.sgml : 20230222 20230222161107 ACCESSION NUMBER: 0001193125-23-044824 CONFORMED SUBMISSION TYPE: N-CSR PUBLIC DOCUMENT COUNT: 4 CONFORMED PERIOD OF REPORT: 20221231 FILED AS OF DATE: 20230222 DATE AS OF CHANGE: 20230222 EFFECTIVENESS DATE: 20230222 FILER: COMPANY DATA: COMPANY CONFORMED NAME: T. Rowe Price Health Sciences Fund, Inc. CENTRAL INDEX KEY: 0001002624 IRS NUMBER: 521952906 STATE OF INCORPORATION: MD FISCAL YEAR END: 1231 FILING VALUES: FORM TYPE: N-CSR SEC ACT: 1940 Act SEC FILE NUMBER: 811-07381 FILM NUMBER: 23653211 BUSINESS ADDRESS: STREET 1: 100 EAST PRATT STREET CITY: BALTIMORE STATE: MD ZIP: 21202 BUSINESS PHONE: 410-345-2000 MAIL ADDRESS: STREET 1: 100 EAST PRATT STREET CITY: BALTIMORE STATE: MD ZIP: 21202 FORMER COMPANY: FORMER CONFORMED NAME: PRICE T ROWE HEALTH SCIENCES FUND INC DATE OF NAME CHANGE: 19980513 FORMER COMPANY: FORMER CONFORMED NAME: PRICE T ROWE HEALTH & LIFE SCIENCES FUND INC DATE OF NAME CHANGE: 19951023 0001002624 S000002088 T. Rowe Price Health Sciences Fund, Inc. C000005456 T. Rowe Price Health Sciences Fund, Inc. PRHSX C000169937 T. Rowe Price Health Sciences Fund-I Class THISX N-CSR 1 d403076dncsr.htm HEALTH SCIENCES FUND_HSF_F114-050 Health Sciences Fund_HSF_F114-050

UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549

FORM N-CSR

CERTIFIED SHAREHOLDER REPORT OF REGISTERED

MANAGEMENT INVESTMENT COMPANIES

Investment Company Act File Number: 811-07381

T. Rowe Price Health Sciences Fund, Inc.

 

(Exact name of registrant as specified in charter)

100 East Pratt Street, Baltimore, MD 21202

 

(Address of principal executive offices)

David Oestreicher

100 East Pratt Street, Baltimore, MD 21202

 

(Name and address of agent for service)

Registrant’s telephone number, including area code: (410) 345-2000

Date of fiscal year end: December 31

Date of reporting period: December 31, 2022


Item 1. Reports to Shareholders

(a) Report pursuant to Rule 30e-1


Highlights
and
Market
Commentary
Management’s
Discussion
of
Fund
Performance
Performance
and
Expenses
Financial
Highlights
Portfolio
of
Investments
Financial
Statements
and
Notes
Additional
Fund
Information
December
31,
2022
Annual
Report
For
more
insights
from
T.
Rowe
Price
investment
professionals,
go
to
troweprice.com
.
T.
ROWE
PRICE
PRHSX
Health
Sciences
Fund
.
THISX
Health
Sciences
Fund–
.
I Class
T.
ROWE
PRICE
Health
Sciences
Fund
HIGHLIGHTS
The
Health
Sciences
Fund
outperformed
its
benchmark
and
the
broad
equity
market
in
the
12
months
ended
December
31,
2022.
Allocation
effects
drove
outperformance,
while
stock
selection
detracted.
The
services
and
pharmaceuticals
subsectors
contributed
the
most
to
relative
performance,
while
biotechnology
and
life
sciences
detracted.
While
we
expect
the
macroeconomic
backdrop
to
remain
challenging
in
the
near
term,
we
maintain
an
optimistic
outlook
for
the
sector
going
forward.
We
believe
investors
need
to
be
selective,
and
we
are
staying
true
to
our
philosophy
of
investing
in
highly
innovative
therapeutic
companies
and
companies
that
can
improve
the
standard
of
care
in
a
cost-effective
manner,
which
has
served
us
well
over
time.
Log
in
to
your
account
at
troweprice.com
for
more
information.
*
Certain
mutual
fund
accounts
that
are
assessed
an
annual
account
service
fee
can
also
save
money
by
switching
to
e-delivery.
T.
ROWE
PRICE
Health
Sciences
Fund
Market
Commentary
1
Dear
Shareholder
Nearly
all
major
global
stock
and
bond
indexes
fell
sharply
in
2022,
as
investors
contended
with
persistently
high
inflation,
tightening
financial
conditions,
and
slowing
economic
and
corporate
earnings
growth.
Double-digit
losses
were
common
in
equity
markets
around
the
world,
and
bond
investors
also
faced
a
historically
tough
environment
amid
a
sharp
rise
in
interest
rates.
Value
shares
declined
but
outperformed
growth
stocks
by
a
considerable
margin
as
equity
investors
turned
risk
averse
and
as
rising
rates
put
downward
pressure
on
growth
stock
valuations.
Emerging
markets
stocks
generally
underperformed
shares
in
developed
markets.
Meanwhile,
the
U.S.
dollar
strengthened
versus
most
currencies
during
the
period,
which
weighed
on
returns
for
U.S.
investors
in
international
securities.
Within
the
S&P
500
Index,
energy
was
a
rare
bright
spot,
gaining
more
than
60%
as
oil
prices
jumped
in
response
to
Russia’s
invasion
of
Ukraine
and
concerns
over
commodity
supply
shortages.
Defensive
shares,
such
as
utilities,
consumer
staples,
and
health
care,
held
up
relatively
well
and
finished
the
year
with
roughly
flat
returns.
Conversely,
communication
services,
consumer
discretionary,
and
information
technology
shares
suffered
the
largest
declines.
Elevated
inflation
remained
a
leading
concern
for
investors
throughout
the
period,
although
there
were
signs
that
price
increases
were
moderating
by
year-
end.
November’s
consumer
price
index
data
showed
headline
inflation
rising
7.1%
on
a
12-month
basis,
the
lowest
level
since
December
2021
but
still
well
above
the
Federal
Reserve’s
2%
long-term
target.
In
response
to
the
high
inflation
readings,
global
central
banks
tightened
monetary
policy,
and
investors
focused
on
communications
from
central
bank
officials
on
how
high
rates
would
have
to
go.
The
Fed,
which
at
the
end
of
2021
had
forecast
that
it
would
only
need
to
raise
interest
rates
0.75
percentage
point
in
all
of
2022,
raised
its
short-term
lending
benchmark
from
near
zero
in
March
to
a
target
range
of
4.25%
to
4.50%
by
December
and
indicated
that
additional
hikes
are
likely.
Bond
yields
increased
considerably
across
the
U.S.
Treasury
yield
curve
as
the
Fed
tightened
monetary
policy,
with
the
yield
on
the
benchmark
10-year
U.S.
Treasury
note
climbing
from
1.52%
at
the
start
of
the
period
to
3.88%
at
the
end
of
the
year.
Significant
inversions
in
the
yield
curve,
which
are
often
considered
a
warning
sign
of
a
coming
recession,
occurred
during
the
period
as
shorter-maturity
Treasuries
experienced
the
largest
yield
increases.
The
T.
ROWE
PRICE
Health
Sciences
Fund
2
sharp
increase
in
yields
led
to
historically
weak
results
across
the
fixed
income
market,
with
the
Bloomberg
U.S.
Aggregate
Bond
Index
delivering
its
worst
year
on
record.
(Bond
prices
and
yields
move
in
opposite
directions.)
As
the
period
came
to
an
end,
the
economic
backdrop
appeared
mixed.
Although
manufacturing
gauges
have
drifted
toward
contraction
levels,
the
U.S.
jobs
market
remained
resilient,
and
corporate
and
household
balance
sheets
appeared
strong.
Meanwhile,
the
housing
market
has
weakened
amid
rising
mortgage
rates.
The
past
year
has
been
a
trying
time
for
investors
as
few
sectors
remained
untouched
by
the
broad
headwinds
that
markets
faced,
and
volatility
may
continue
in
the
near
term
as
central
banks
tighten
policy
amid
slowing
economic
growth.
However,
in
our
view,
there
continue
to
be
opportunities
for
selective
investors
focused
on
fundamentals.
Valuations
in
most
global
equity
markets
have
improved
markedly,
although
U.S.
equities
still
appear
relatively
expensive
by
historical
standards,
while
bond
yields
have
reached
some
of
the
most
attractive
levels
since
the
2008
global
financial
crisis.
We
believe
this
environment
makes
skilled
active
management
a
critical
tool
for
identifying
risks
and
opportunities,
and
our
investment
teams
will
continue
to
use
fundamental
research
to
identify
securities
that
can
add
value
to
your
portfolio
over
the
long
term.
Thank
you
for
your
continued
confidence
in
T.
Rowe
Price.
Sincerely, 
Robert
Sharps
CEO
and
President
T.
ROWE
PRICE
Health
Sciences
Fund
Management’s
Discussion
of
Fund
Performance
3
INVESTMENT
OBJECTIVE 
The
fund
seeks
long-term
capital
appreciation.
FUND
COMMENTARY
How
did
the
fund
perform
in
the
past 12
months?
The
Health
Sciences
Fund
returned
-12.19%
in
the
12-month
period
ended
December
31,
2022.
The
fund
outperformed
its
benchmark,
the
Lipper
Health/
Biotechnology
Funds
Index,
and
the
broad
equity
market
as
measured
by
the
S&P
500
Index.
(Returns
for
I
Class
shares
varied
slightly,
reflecting
their
different
fee
structure.
Past
performance
cannot
guarantee
future
results
.)
What
factors
influenced
the
fund’s
performance?
Allocation
effects
drove
outperformance,
while
stock
selection
detracted.
However,
we
believe
our
focus
on
bottom-up
stock
selection
will
be
the
primary
long-term
performance
driver
as
shown
in
the
Growth
of
$10,000
chart
on
page
9.
The
portfolio’s
overweight
exposure
to
services
contributed
the
most
to
relative
returns;
stock
choices
in
the
group
also
assisted.
Select
managed
care
names
such
as
UnitedHealth
Group
and
Elevance
Health
added
value.
The
group
benefited
from
strong
fundamentals
driven
by
a
robust
commercial
pricing
environment,
broadly
in-line
health
care
utilization
trends,
and
abating
political
overhangs.
Additionally,
these
are
largely
U.S.
domestic-oriented
businesses
with
strong
cash
flows
that
have
demonstrated
the
ability
to
adjust
price
and/or
benefits
in
response
to
cost
inflation,
which
investors
have
appreciated.
An
overweight
exposure
to
larger-cap
pharmaceuticals,
which
benefited
from
their
more
defensive
characteristics,
was
another
source
of
relative
strength.
Investors’
preference
for
companies
with
strong
balance
sheets
and
cash
flow
generation
in
an
environment
with
persistent
inflation
and
rising
interest
rates
benefited
firms
such
as
Merck
and
Eli
Lilly.
PERFORMANCE
COMPARISON
Total
Return
Periods
Ended
12/31/22
6
Months
12
Months
Health
Sciences
Fund
.
6.60‌%
-12.19‌%
Health
Sciences
Fund–
.
I  Class
6.67‌
-12.08‌
S&P
500
Index
2.31‌
-18.11‌
Lipper
Health/
Biotechnology
Funds
Index
10.33‌
-12.94‌
T.
ROWE
PRICE
Health
Sciences
Fund
4
Conversely,
stock
picks
in
the
biotechnology
subsector
detracted.
The
portfolio’s
underweight
position
in
several
names
that
outperformed
during
the
year,
mainly
due
to
positive
data
readouts,
weighed
on
relative
returns.
Shares
of
Karuna
Therapeutics
traded
sharply
higher
following
a
positive
Phase
3
data
readout
for
its
potential
schizophrenia
treatment
in
early
August,
which
significantly
improved
the
drug’s
chances
of
approval
by
the
U.S.
Food
and
Drug
Administration.
Although
we
added
to
our
position
in
Karuna
before
and
after
the
data
readout,
our
underweight
allocation
hurt
performance.
While
a
leadership-change
announcement
in
early
December
weighed
on
the
stock
more
recently,
we
remain
constructive
on
the
company
as
we
believe
there
is
a
significant
amount
of
upside
to
be
captured
in
its
paradigm-shifting
therapy
for
schizophrenia.
An
overweight
exposure
to
life
sciences,
the
worst-performing
segment
in
the
benchmark
during
the
year,
also
lowered
relative
returns;
however,
stock
selection
in
the
group
helped
mitigate
losses.
Growing
concerns
of
a
slowdown
in
COVID-19
vaccine-related
demand
weighed
on
larger
companies
with
bioprocessing
exposure
within
the
sector,
while
smaller-cap,
more
capital-
intensive
companies
were
hurt
by
rapidly
rising
interest
rates.
However,
we
think
the
longer-term
outlook
for
the
group
remains
favorable,
supported
by
the
ongoing
innovation
in
biopharma.
How
is
the
fund
positioned?
From
a
high
level,
the
areas
that
we
have
always
favored
(companies
developing
innovative,
game-changing
therapies
and
companies
that
are
improving
the
standard
of
care
in
a
cost-effective
manner)
will
remain
areas
we
focus
on
because
that
is
where
we
think
investors
can
realize
long-term
value.
From
a
subsector
perspective,
biotechnology
represents
the
portfolio’s
largest
exposure.
While
we
remain
committed
to
investing
in
innovative
companies
developing
new
medicines,
we
recognize
the
environment
for
smaller
biotechnology
companies
has
changed,
as
raising
capital
has
become
more
difficult.
As
such,
we
have
set
a
higher
bar
for
owning
nonprofitable
INDUSTRY
DIVERSIFICATION
Percent
of
Net
Assets
6/30/22
12/31/22
Biotechnology
25.2‌%
26.8‌%
Services
24.3‌
23.6‌
Pharmaceuticals
17.3‌
18.0‌
Life
Sciences
15.8‌
15.9‌
Products
and
Devices
16.6‌
14.7‌
Consumer
Nondurables
0.6‌
0.2‌
Other
and
Reserves
0.2‌
0.8‌
Total
100.0‌%
100.0‌%
Historical
weightings
reflect
current
industry/sector
classifications.
T.
ROWE
PRICE
Health
Sciences
Fund
5
biotechnology
companies.
Conversely,
we
have
found
opportunities
to
selectively
add
to
larger-cap
biotechnology
companies
with
strong
research
and
development
capabilities
that
are
profitable
and
fairly
valued
given
the
likelihood
that
higher
interest
rates
and
higher
inflation
will
remain
for
longer
than
many
expect.
We
added
to
our
position
in
Regeneron
Pharmaceuticals,
a
commercial-stage
biotechnology
company
focused
on
the
development
and
commercialization
of
biologic
drugs.
We
believe
the
recent
success
of
two
Phase
3
trials
for
high-
dose
Eylea,
an
injection
indicated
to
treat
a
variety
of
ocular
diseases,
was
a
significant
step
in
the
life-cycle
management
of
the
company’s
blockbuster
drug.
We
think
the
positive
readouts
substantially
extend
the
revenue
runway
for
the
company,
and
we
believe
the
valuation
remains
favorable
given
its
now-durable
growth
profile.
Conversely,
we
eliminated
our
position
in
Amgen
on
strength
during
the
second
quarter.
While
the
company
has
a
growing
dividend,
solid
cash
flow
generation,
and
a
strong
internal
research
and
development
program,
the
stock
had
become
more
fairly
valued
in
our
view,
due
to
investor
interest
in
companies
with
pharma-like
profiles,
and
we
elected
to
take
profits
and
fund
other
higher-conviction
ideas.
With
limited
inflation
and
input
cost
pressures
as
well
as
strong
balance
sheets
and
cash
flow
generation,
larger-cap
pharmaceuticals
have
benefited
from
their
more
defensive
characteristics.
Given
rising
recession
uncertainties
and
the
diminished
investor
appetite
for
risk-taking,
we
have
modestly
increased
our
exposure
to
the
group.
We
added
shares
of
Merck,
which
we
believe
should
be
able
to
drive
revenue
growth
in
the
medium
term
with
its
human
papillomavirus
vaccine
Gardasil,
its
oncology
treatments
Lenvima
and
Lynparza,
as
well
as
its
animal
health
business.
Merck
may
also
be
able
to
utilize
its
strong
balance
sheet
and
cash
flows
to
finance
significant
acquisitions
and
bolster
its
pipeline.
Conversely,
we
scaled
back
our
position
in
Pfizer
as
the
stock’s
near-term
outlook
is
heavily
tied
to
its
COVID
portfolio,
which
remains
difficult
to
forecast.
Within
the
services
subsector,
our
largest
exposure
is
to
the
structurally
growing
managed
care
industry,
where
fundamentals
remain
strong
given
a
favorable
commercial
pricing
environment.
Within
the
space,
we
have
significant
positions
in
UnitedHealth
Group,
Humana,
and
Elevance
Health.
Regarding
Elevance,
which
was
our
largest
addition
in
the
subsector
during
the
period,
we
think
it
offers
an
attractive
mix
of
company-specific
growth
drivers
at
a
compelling
valuation
when
considering
the
company’s
room
for
improving
returns
and
long
runway
for
growth
with
its
Medicaid
and
Medicare
Advantage
businesses.
T.
ROWE
PRICE
Health
Sciences
Fund
6
The
portfolio
is
overweight
life
sciences
companies,
which
develop
the
platforms,
instrumentation,
and
technology
that
drives
future
discovery
and
the
application
of
drugs
and
diagnostics.
Fundamentals
overall
remain
exceptional.
Within
the
space,
we
have
core
positions
in
Thermo
Fisher
Scientific,
Danaher,
and
Agilent
Technologies.
What
is
portfolio
management’s
outlook?
Macroeconomic
factors
dominated
equity
market
performance
in
2022,
with
higher
interest
rates,
rising
inflation,
and
growing
recessionary
fears
weighing
on
investor
confidence.
While
we
expect
the
macroeconomic
backdrop
to
remain
challenging
in
the
near
term,
we
maintain
an
optimistic
outlook
for
the
sector
going
forward.
We
are
seeing
great
progress
across
a
number
of
therapeutic
platforms,
including
oncology,
neurology,
ophthalmology,
and
autoimmune
and
infectious
diseases,
and
the
market
environment
for
companies
developing
innovative
therapies
remains
encouraging.
Even
with
the
groundbreaking
developments
we
have
seen
over
the
last
several
years,
there
is
still
a
strong
pipeline
for
future
innovation
given
the
large
number
of
disorders,
such
as
cancer,
Alzheimer’s,
obesity,
and
diabetes,
affecting
large
populations
in
need
of
improved
treatment
options.
As
a
result
of
ongoing
scientific
advancement
and
improvement,
we
believe
we
are
on
the
cusp
of
a
significant
wave
of
innovation
that
should
lead
to
meaningful
drug
launches
in
the
coming
years
that
will
cure
diseases
or
dramatically
improve
quality
of
life.
Encouragingly,
innovation
is
occurring
in
companies
of
all
sizes,
and
we
continue
to
own
a
well-diversified
portfolio
of
names
across
the
health
care
landscape.
Although
we
believe
investors
must
remain
selective
amid
this
period
of
near-term
uncertainty,
we
are
staying
true
to
our
investment
philosophy
and
process.
The
views
expressed
reflect
the
opinions
of
T.
Rowe
Price
as
of
the
date
of
this
report
and
are
subject
to
change
based
on
changes
in
market,
economic,
or
other
conditions.
These
views
are
not
intended
to
be
a
forecast
of
future
events
and
are
no
guarantee
of
future
results.
T.
ROWE
PRICE
Health
Sciences
Fund
7
RISKS
OF
GROWTH
INVESTING
Growth
stocks
can
be
volatile
for
several
reasons.
Since
these
companies
usually
invest
a
high
portion
of
earnings
in
their
businesses,
they
may
lack
the
dividends
of
value
stocks
that
can
cushion
stock
prices
in
a
falling
market.
Also,
earnings
disappointments
often
lead
to
sharply
falling
prices
because
investors
buy
growth
stocks
in
anticipation
of
superior
earnings
growth.
RISKS
OF
HEALTH
SCIENCES
FUND
INVESTING
Funds
that
invest
only
in
specific
industries
will
experience
greater
volatility
than
funds
investing
in
a
broad
range
of
industries.
Companies
in
the
health
sciences
field
are
subject
to
special
risks
such
as
increased
competition
within
the
health
care
industry,
changes
in
legislation
or
government
regulations,
reductions
in
government
funding,
product
liability
or
other
litigation,
and
the
obsolescence
of
popular
products.
BENCHMARK
INFORMATION
Note:
Portions
of
the
mutual
fund
information
contained
in
this
report
was
supplied
by
Lipper,
a
Refinitiv
Company,
subject
to
the
following:
Copyright
2023
©
Refinitiv.
All
rights
reserved.
Any
copying,
republication
or
redistribution
of
Lipper
content
is
expressly
prohibited
without
the
prior
written
consent
of
Lipper.
Lipper
shall
not
be
liable
for
any
errors
or
delays
in
the
content,
or
for
any
actions
taken
in
reliance
thereon.
Note:
The
S&P
500
Index
is
a
product
of
S&P
Dow
Jones
Indices
LLC,
a
division
of
S&P
Global,
or
its
affiliates
(“SPDJI”)
and
has
been
licensed
for
use
by
T.
Rowe
Price.
Standard
&  Poor’s
®
and
S&P
®
 are
registered
trademarks of
Standard
&
Poor’s
Financial
Services
LLC,
a
division
of
S&P
Global (“S&P”);
Dow
Jones
®
is
a
registered
trademark
of
Dow
Jones
Trademark
Holdings
LLC
(“Dow
Jones”);
T.
Rowe
Price
is
not
sponsored,
endorsed,
sold
or
promoted
by
SPDJI,
Dow
Jones,
S&P,
or
their
respective
affiliates,
and
none
of
such
parties
make
any
representation
regarding
the
advisability
of
investing
in
such
product(s)
nor
do
they
have
any
liability
for
any
errors,
omissions,
or
interruptions
of
the
S&P
500
Index.
T.
ROWE
PRICE
Health
Sciences
Fund
8
PORTFOLIO
HIGHLIGHTS
TWENTY-FIVE
LARGEST
HOLDINGS
Percent
of
Net
Assets
12/31/22
UnitedHealth
Group
8.7‌%
Thermo
Fisher
Scientific
5.1‌ 
Eli
Lilly
4.5‌ 
Danaher
3.8‌ 
Merck
3.5‌ 
AstraZeneca
3.4‌ 
Elevance
Health
3.2‌ 
Regeneron
Pharmaceuticals
3.0‌ 
Intuitive
Surgical
3.0‌ 
Stryker
2.3‌ 
Pfizer
2.3‌ 
Alnylam
Pharmaceuticals
2.3‌ 
Vertex
Pharmaceuticals
2.2‌ 
Humana
2.2‌ 
Agilent
Technologies
2.0‌ 
Becton
Dickinson
&
Company
1.8‌ 
AbbVie
1.7‌ 
Centene
1.7‌ 
Argenx
1.7‌ 
Molina
Healthcare
1.6‌ 
Cigna
1.5‌ 
Moderna
1.2‌ 
Penumbra
0.9‌ 
Hologic
0.9‌ 
HCA
Healthcare
0.9‌ 
Total
65.4‌%
Note:
The
information
shown
does
not
reflect
any
exchange-traded
funds
(ETFs),
cash
reserves,
or
collateral
for
securities
lending
that
may
be
held
in
the
portfolio.
T.
ROWE
PRICE
Health
Sciences
Fund
9
GROWTH
OF
$10,000 
This
chart
shows
the
value
of
a
hypothetical
$10,000
investment
in
the
fund
over
the
past
10
fiscal
year
periods
or
since
inception
(for funds
lacking
10-year
records).
The
result
is
compared
with
benchmarks,
which
include
a
broad-based
market
index
and
may
also
include
a
peer
group
average
or
index.
Market
indexes
do
not
include
expenses,
which
are
deducted
from
fund returns
as
well
as
mutual fund
averages
and
indexes.
HEALTH
SCIENCES
FUND 
Note:
Performance
for
the
I
Class share
will
vary
due
to
its differing
fee
structure.
See
the
Average
Annual
Compound
Total
Return
table. 
T.
ROWE
PRICE
Health
Sciences
Fund
10
AVERAGE
ANNUAL
COMPOUND
TOTAL
RETURN
Periods
Ended
12/31/22
1
Year
5
Years
10
Years
Since
Inception
Inception
Date
Health
Sciences
Fund
.
-12.19‌%
11.08‌%
15.91‌%
–‌
Health
Sciences
Fund–
.
I  Class
-12.08‌
11.21‌
–‌
12.77‌%
3/23/16
The
fund’s
performance
information
represents
only
past
performance
and
is
not
necessarily
an
indication
of
future
results.
Current
performance
may
be
lower
or
higher
than
the
performance
data
cited.
Share
price,
principal
value,
and
return
will
vary,
and
you
may
have
a
gain
or
loss
when
you
sell
your
shares.
For
the
most
recent
month-end
performance,
please
visit
our
website
(troweprice.com)
or
contact
a
T.
Rowe
Price
representative
at
1
-
800
-
225
-
5132
or,
for
0.02
I
Class
shares,
1-800-638-8790.
This
table
shows
how
the
fund
would
have
performed
each
year
if
its
actual
(or
cumulative)
returns
had
been
earned
at
a
constant
rate.
Average
annual
total
return
figures
include
changes
in
principal
value,
reinvested
dividends,
and
capital
gain
distributions.
Returns
do
not
reflect
taxes
that
the
shareholder
may
pay
on
fund
distributions
or
the
redemption
of
fund
shares.
When
assessing
performance,
investors
should
consider
both
short-
and
long-term
returns.
T.
ROWE
PRICE
Health
Sciences
Fund
11
EXPENSE
RATIO
FUND
EXPENSE
EXAMPLE
As
a
mutual
fund
shareholder,
you
may
incur
two
types
of
costs:
(1)
transaction
costs,
such
as
redemption
fees
or
sales
loads,
and
(2)
ongoing
costs,
including
management
fees,
distribution
and
service
(12b-1)
fees,
and
other
fund
expenses.
The
following
example
is
intended
to
help
you
understand
your
ongoing
costs
(in
dollars)
of
investing
in
the
fund
and
to
compare
these
costs
with
the
ongoing
costs
of
investing
in
other
mutual
funds.
The
example
is
based
on
an
investment
of
$1,000
invested
at
the
beginning
of
the
most
recent
six-month
period
and
held
for
the
entire
period.
Please
note
that
the
fund
has
two
share
classes:
The
original
share
class
(Investor
Class)
charges
no
distribution
and
service
(12b-1)
fee,
and
the
I
Class
shares
are
also
available
to
institutionally
oriented
clients
and
impose
no
12b-1
or
administrative
fee
payment.
Each
share
class
is
presented
separately
in
the
table.
Actual
Expenses
The
first
line
of
the
following
table
(Actual)
provides
information
about
actual
account
values
and
expenses
based
on
the
fund’s
actual
returns.
You
may
use
the
information
on
this
line,
together
with
your
account
balance,
to
estimate
the
expenses
that
you
paid
over
the
period.
Simply
divide
your
account
value
by
$1,000
(for
example,
an
$8,600
account
value
divided
by
$1,000
=
8.6),
then
multiply
the
result
by
the
number
on
the
first
line
under
the
heading
“Expenses
Paid
During
Period”
to
estimate
the
expenses
you
paid
on
your
account
during
this
period.
Hypothetical
Example
for
Comparison
Purposes
The
information
on
the
second
line
of
the
table
(Hypothetical)
is
based
on
hypothetical
account
values
and
expenses
derived
from
the
fund’s
actual
expense
ratio
and
an
assumed
5%
per
year
rate
of
return
before
expenses
(not
the
fund’s
actual
return).
You
may
compare
the
ongoing
costs
of
investing
in
the
fund
with
other
funds
by
contrasting
this
5%
hypothetical
example
and
the
5%
hypothetical
examples
that
appear
in
the
shareholder
reports
of
the
other
funds.
The
hypothetical
account
values
and
expenses
may
not
be
used
to
estimate
the
actual
ending
account
balance
or
expenses
you
paid
for
the
period.
Health
Sciences
Fund
0.75‌%
Health
Sciences
Fund–I
Class
0.65‌ 
The
expense
ratio
shown
is
as
of
the
fund’s
most
recent
prospectus.
This
number
may
vary
from
the
expense
ratio
shown
elsewhere
in
this
report
because
it
is
based
on
a
different
time
period
and,
if
applicable,
includes
acquired
fund
fees
and
expenses
but
does
not
include
fee
or
expense
waivers.
T.
ROWE
PRICE
Health
Sciences
Fund
12
Note:
T.
Rowe
Price
charges
an
annual
account
service
fee
of
$20,
generally
for
accounts
with
less
than
$10,000.
The
fee
is
waived
for
any
investor
whose
T.
Rowe
Price
mutual
fund
accounts
total
$50,000
or
more;
accounts
electing
to
receive
electronic
delivery
of
account
statements,
transaction
confirmations,
prospectuses,
and
shareholder
reports;
or
accounts
of
an
investor
who
is
a
T.
Rowe
Price
Personal
Services
or
Enhanced
Personal
Services
client
(enrollment
in
these
programs
generally
requires
T.
Rowe
Price
assets
of
at
least
$250,000).
This
fee
is
not
included
in
the
accompanying
table.
If
you
are
subject
to
the
fee,
keep
it
in
mind
when
you
are
estimating
the
ongoing
expenses
of
investing
in
the
fund
and
when
comparing
the
expenses
of
this
fund
with
other
funds.
You
should
also
be
aware
that
the
expenses
shown
in
the
table
highlight
only
your
ongoing
costs
and
do
not
reflect
any
transaction
costs,
such
as
redemption
fees
or
sales
loads.
Therefore,
the
second
line
of
the
table
is
useful
in
comparing
ongoing
costs
only
and
will
not
help
you
determine
the
relative
total
costs
of
owning
different
funds.
To
the
extent
a
fund
charges
transaction
costs,
however,
the
total
cost
of
owning
that
fund
is
higher.
HEALTH
SCIENCES
FUND
Beginning
Account
Value
7/1/22
Ending
Account
Value
12/31/22
Expenses
Paid
During
Period*
7/1/22
to
12/31/22
Health
Sciences
Fund
Actual
$1,000.00
$1,066.00
$4.17
Hypothetical
(assumes
5%
return
before
expenses)
 1,000.00
  1,021.17
  4.08
Health
Sciences
Fund–I
Class
Actual
  1,000.00
  1,066.70
  3.49
Hypothetical
(assumes
5%
return
before
expenses)
 1,000.00
  1,021.83
  3.41
*
Expenses
are
equal
to
the
fund’s
annualized
expense
ratio
for
the
6-month
period,
multiplied
by
the
average
account
value
over
the
period,
multiplied
by
the
number
of
days
in
the
most
recent
fiscal
half
year
(184),
and
divided
by
the
days
in
the
year
(365)
to
reflect
the
half-year
period.
The
annualized
expense
ratio
of
the
1
Investor
Class
was
0.80%,
and
the
2
I Class
was
0.67%.
FUND
EXPENSE
EXAMPLE
(CONTINUED)
T.
ROWE
PRICE
Health
Sciences
Fund
Financial
Highlights
13
For
a
share
outstanding
throughout
each
period
Investor
Class
..
Year
..
..
Ended
.
12/31/22
12/31/21
12/31/20
12/31/19
12/31/18
NET
ASSET
VALUE
Beginning
of
period
$
104.08‌
$
98.85‌
$
81.43‌
$
67.01‌
$
70.35‌
Investment
activities
Net
investment
income
(loss)
(1)(2)
(0.09‌)
(0.22‌)
(0.04‌)
—‌
(3)
0.04‌
Net
realized
and
unrealized
gain/
loss
(12.58‌)
13.21‌
24.54‌
19.45‌
1.02‌
Total
from
investment
activities
(12.67‌)
12.99‌
24.50‌
19.45‌
1.06‌
Distributions
Net
investment
income
—‌
—‌
—‌
(0.05‌)
—‌
Net
realized
gain
(1.59‌)
(7.76‌)
(7.08‌)
(4.98‌)
(4.40‌)
Total
distributions
(1.59‌)
(7.76‌)
(7.08‌)
(5.03‌)
(4.40‌)
NET
ASSET
VALUE
End
of
period
$
89.82‌
$
104.08‌
$
98.85‌
$
81.43‌
$
67.01‌
T.
ROWE
PRICE
Health
Sciences
Fund
Financial
Highlights
14
For
a
share
outstanding
throughout
each
period
The
accompanying
notes
are
an
integral
part
of
these
financial
statements.
Investor
Class
..
Year
..
..
Ended
.
12/31/22
12/31/21
12/31/20
12/31/19
12/31/18
Ratios/Supplemental
Data
Total
return
(2)(4)
(12.19‌)%
13.27‌%
30.12‌%
29.11‌%
1.23‌%
Ratios
to
average
net
assets:
(2)
Gross
expenses
before
waivers/
payments
by
Price
Associates
0.80‌%
0.75‌%
0.76‌%
0.76‌%
0.77‌%
Net
expenses
after
waivers/
payments
by
Price
Associates
0.80‌%
0.75‌%
0.76‌%
0.76‌%
0.77‌%
Net
investment
income
(loss)
(0.10‌)%
(0.21‌)%
(0.05‌)%
0.00‌%
0.05‌%
Portfolio
turnover
rate
28.8‌%
33.8‌%
41.7‌%
38.8‌%
43.0‌%
Net
assets,
end
of
period
(in
millions)
$10,235
$17,213
$15,753
$12,649
$10,666
0‌%
0‌%
0‌%
0‌%
0‌%
(1)
Per
share
amounts
calculated
using
average
shares
outstanding
method.
(2)
See
Note
6
for
details
of
expense-related
arrangements
with
Price
Associates.
(3)
Amounts
round
to
less
than
$0.01
per
share.
(4)
Total
return
reflects
the
rate
that
an
investor
would
have
earned
on
an
investment
in
the
fund
during
each
period,
assuming
reinvestment
of
all
distributions,
and
payment
of
no
redemption
or
account
fees,
if
applicable.
T.
ROWE
PRICE
Health
Sciences
Fund
Financial
Highlights
15
For
a
share
outstanding
throughout
each
period
The
accompanying
notes
are
an
integral
part
of
these
financial
statements.
I
Class
..
Year
..
..
Ended
.
12/31/22
12/31/21
12/31/20
12/31/19
12/31/18
NET
ASSET
VALUE
Beginning
of
period
$
104.05‌
$
98.87‌
$
81.42‌
$
67.00‌
$
70.34‌
Investment
activities
Net
investment
income
(loss)
(1)(2)
0.05‌
(0.11‌)
0.05‌
0.08‌
0.14‌
Net
realized
and
unrealized
gain/
loss
(12.60‌)
13.22‌
24.57‌
19.46‌
1.01‌
Total
from
investment
activities
(12.55‌)
13.11‌
24.62‌
19.54‌
1.15‌
Distributions
Net
investment
income
—‌
—‌
—‌
(0.14‌)
—‌
Net
realized
gain
(1.59‌)
(7.93‌)
(7.17‌)
(4.98‌)
(4.49‌)
Total
distributions
(1.59‌)
(7.93‌)
(7.17‌)
(5.12‌)
(4.49‌)
NET
ASSET
VALUE
End
of
period
$
89.91‌
$
104.05‌
$
98.87‌
$
81.42‌
$
67.00‌
Ratios/Supplemental
Data
Total
return
(2)(3)
(12.08‌)%
13.40‌%
30.27‌%
29.25‌%
1.35‌%
Ratios
to
average
net
assets:
(2)
Gross
expenses
before
waivers/
payments
by
Price
Associates
0.67‌%
0.65‌%
0.65‌%
0.65‌%
0.66‌%
Net
expenses
after
waivers/
payments
by
Price
Associates
0.67‌%
0.65‌%
0.65‌%
0.65‌%
0.66‌%
Net
investment
income
(loss)
0.05‌%
(0.10‌)%
0.06‌%
0.11‌%
0.18‌%
Portfolio
turnover
rate
28.8‌%
33.8‌%
41.7‌%
38.8‌%
43.0‌%
Net
assets,
end
of
period
(in
thousands)
$5,937,842
$2,295,409
$1,679,405
$1,154,768
$835,422
0‌%
0‌%
0‌%
0‌%
0‌%
(1)
Per
share
amounts
calculated
using
average
shares
outstanding
method.
(2)
See
Note
6
for
details
of
expense-related
arrangements
with
Price
Associates.
(3)
Total
return
reflects
the
rate
that
an
investor
would
have
earned
on
an
investment
in
the
fund
during
each
period,
assuming
reinvestment
of
all
distributions,
and
payment
of
no
redemption
or
account
fees,
if
applicable.
T.
ROWE
PRICE
Health
Sciences
Fund
December
31,
2022
16
Portfolio
of
Investments
Shares
$
Value
(Cost
and
value
in
$000s)
COMMON
STOCKS
94.2%
BIOTECHNOLOGY
22.1%
International-Biotechnology
0.0%
Ideaya
Biosciences  (1)
134,265‌
2,440‌
2,440‌
Major
Biotechnology
4.9%
Biogen (1)
357,689‌
99,051‌
BioNTech,
ADR 
560,841‌
84,250‌
Celldex
Therapeutics  (1)
628,343‌
28,005‌
Exact
Sciences  (1)
952,069‌
47,137‌
Exact
Sciences
CMO
Milestone,
Acquisition
Date:
1/6/21,
Cost $—  (1)(2)(3)
3,726,272‌
1,975‌
Exact
Sciences
Expense
Fund,
Acquisition
Date:
1/6/21,
Cost $—  (1)(2)(3)
3,795‌
4‌
Exact
Sciences
FDA
Milestone,
Acquisition
Date:
1/6/21,
Cost $—  (1)(2)(3)
1,863,136‌
988‌
Neurocrine
Biosciences  (1)
343,178‌
40,989‌
Royalty
Pharma,
Class
1,671,948‌
66,075‌
Seagen  (1)
463,072‌
59,509‌
Vertex
Pharmaceuticals  (1)
1,254,616‌
362,308‌
790,291‌
Other
Biotechnology
17.2%
Aadi
Bioscience  (1)
150,289‌
1,928‌
ACADIA
Pharmaceuticals  (1)
1,177,638‌
18,748‌
Acerta
Future
Payments,
EC,
Acquisition
Date:
6/30/21,
Cost $16,465  (1)(2)(3)
16,465,269‌
14,440‌
Adaptive
Biotechnologies  (1)
679,353‌
5,190‌
ADC
Therapeutics  (1)
1,173,088‌
4,505‌
Affinivax
Expense
Fund,
Acquisition
Date:
9/12/22,
Cost $12  (1)
(2)(3)
12,445‌
12‌
Affinivax
Milestone
Event,
Acquisition
Date:
9/12/22,
Cost $3,454  (1)(2)(3)
7,349,672‌
4,410‌
Affinivax
Next
Gen
Prod
Mileston
Event,
Acquisition
Date:
9/12/22,
Cost $3,454  (1)(2)(3)
7,349,672‌
1,617‌
Agios
Pharmaceuticals  (1)
398,930‌
11,202‌
Alector  (1)
344,770‌
3,182‌
Allakos 
966,912‌
8,141‌
Allogene
Therapeutics  (1)
1,862,898‌
11,718‌
Alnylam
Pharmaceuticals  (1)
1,534,426‌
364,656‌
Apellis
Pharmaceuticals  (1)
645,221‌
33,364‌
Arvinas  (1)
519,755‌
17,781‌
Ascendis
Pharma,
ADR  (1)
838,598‌
102,418‌
Avidity
Biosciences  (1)
1,761,822‌
39,095‌
BeiGene,
ADR  (1)
172,720‌
37,988‌
T.
ROWE
PRICE
Health
Sciences
Fund
17
Shares
$
Value
(Cost
and
value
in
$000s)
Bicycle
Therapeutics,
ADR  (1)
254,670‌
7,538‌
Blueprint
Medicines  (1)
1,122,964‌
49,197‌
C4
Therapeutics  (1)
444,170‌
2,621‌
Centessa
Pharmaceuticals,
ADR  (1)
891,078‌
2,762‌
Cerevel
Therapeutics
Holdings  (1)
1,633,045‌
51,506‌
CRISPR
Therapeutics  (1)
260,117‌
10,574‌
Cytokinetics  (1)
427,378‌
19,583‌
Day
One
Biopharmaceuticals  (1)
474,062‌
10,202‌
Denali
Therapeutics  (1)
1,071,059‌
29,786‌
DICE
Therapeutics  (1)
678,522‌
21,170‌
Enanta
Pharmaceuticals  (1)
126,726‌
5,895‌
Entrada
Therapeutics  (1)
667,462‌
9,024‌
EQRx  (1)
896,285‌
2,205‌
EQRx,
Warrants,
12/20/26  (1)
227,520‌
61‌
Evotec
(EUR)  (1)
389,789‌
6,341‌
Exelixis  (1)
2,022,529‌
32,441‌
Exscientia,
ADR  (1)
192,196‌
1,024‌
Fate
Therapeutics  (1)
761,472‌
7,683‌
Flame
Biosciences,
Acquisition
Date:
9/28/20,
Cost $5,500  (1)(2)
(3)
839,721‌
3,854‌
F-star
Therapeutics  (1)
43,784‌
277‌
Generation
Bio  (1)
1,783,502‌
7,009‌
Genmab
(DKK)  (1)
313,129‌
132,389‌
Ginkgo
Bioworks,
Acquisition
Date:
9/17/21,
Cost $—  (1)(3)
212,706‌
112‌
Ginkgo
Bioworks,
Acquisition
Date:
9/17/21,
Cost $—  (1)(3)
212,706‌
102‌
Ginkgo
Bioworks,
Acquisition
Date:
9/17/21,
Cost $—  (1)(3)
212,706‌
93‌
Gyroscope
Therapeutics,
Milestone
Payment
1,
Acquisition
Date:
2/18/22,
Cost $5,684  (1)(2)(3)
5,683,928‌
2,785‌
Gyroscope
Therapeutics,
Milestone
Payment
2,
Acquisition
Date:
2/18/22,
Cost $3,788  (1)(2)(3)
3,788,007‌
1,023‌
Gyroscope
Therapeutics,
Milestone
Payment
3,
Acquisition
Date:
2/18/22,
Cost $3,788  (1)(2)(3)
3,788,007‌
985‌
IGM
Biosciences  (1)
304,853‌
5,186‌
Immuneering,
Class
A  (1)
1,582,394‌
7,675‌
Immunocore
Holdings,
ADR  (1)
1,055,554‌
60,241‌
Incyte  (1)
887,613‌
71,293‌
Insmed  (1)
2,406,290‌
48,078‌
Intellia
Therapeutics  (1)
382,509‌
13,346‌
Invivyd  (1)
288,950‌
433‌
Ionis
Pharmaceuticals  (1)
1,181,634‌
44,630‌
Iovance
Biotherapeutics  (1)
1,231,161‌
7,867‌
IVERIC
bio  (1)
1,835,482‌
39,298‌
Karuna
Therapeutics  (1)
601,875‌
118,269‌
Kodiak
Sciences  (1)
311,256‌
2,229‌
Kronos
Bio  (1)
111,866‌
181‌
Kymera
Therapeutics  (1)
775,316‌
19,352‌
T.
ROWE
PRICE
Health
Sciences
Fund
18
Shares
$
Value
(Cost
and
value
in
$000s)
LianBio,
ADR  (1)
2,115,865‌
3,470‌
Longboard
Pharmaceuticals  (1)
502,243‌
1,587‌
Lyell
Immunopharma  (1)
1,295,155‌
4,494‌
MeiraGTx
Holdings  (1)
207,581‌
1,353‌
Mirati
Therapeutics  (1)
584,574‌
26,487‌
Moderna  (1)
1,045,625‌
187,815‌
Monte
Rosa
Therapeutics  (1)
1,153,343‌
8,777‌
MoonLake
Immunotherapeutics  (1)
678,545‌
7,125‌
Morphic
Holding  (1)
185,013‌
4,949‌
Novocure  (1)
1,176,250‌
86,278‌
Nurix
Therapeutics  (1)
274,027‌
3,009‌
Prelude
Therapeutics  (1)
181,040‌
1,094‌
Prime
Medicine,
Acquisition
Date:
4/19/21,
Cost $7,119  (1)(3)
522,748‌
9,227‌
Progenic
Pharmaceuticals,
CVR  (1)(2)
842,223‌
969‌
Prothena  (1)
649,910‌
39,157‌
PTC
Therapeutics  (1)
203,485‌
7,767‌
RAPT
Therapeutics  (1)
680,443‌
13,473‌
Regeneron
Pharmaceuticals  (1)
681,567‌
491,744‌
REGENXBIO  (1)
108,057‌
2,451‌
Relay
Therapeutics  (1)
1,045,229‌
15,616‌
Repligen  (1)
215,920‌
36,557‌
Replimune
Group  (1)
1,354,276‌
36,836‌
REVOLUTION
Medicines  (1)
1,007,238‌
23,992‌
Rocket
Pharmaceuticals  (1)
468,255‌
9,164‌
Sage
Therapeutics  (1)
550,322‌
20,989‌
Sana
Biotechnology  (1)
1,608,120‌
6,352‌
Sarepta
Therapeutics  (1)
456,820‌
59,195‌
Scholar
Rock,
Warrants,
12/31/25,
Acquisition
Date:
6/17/22,
Cost $—  (1)(3)
151,540‌
769‌
Scholar
Rock
Holding  (1)
1,843,863‌
16,687‌
SpringWorks
Therapeutics  (1)
159,530‌
4,149‌
Stoke
Therapeutics  (1)
255,805‌
2,361‌
Tenaya
Therapeutics  (1)
1,170,563‌
2,353‌
Theseus
Pharmaceuticals  (1)
1,009,115‌
5,025‌
Ultragenyx
Pharmaceutical  (1)
1,346,360‌
62,377‌
Vividion
Therapeutics,
Milestone
Payment,
Acquisition
Date:
8/25/21,
Cost $—  (1)(2)(3)
2,328,482‌
1,049‌
Vividion
Therapeutics,
Milestone
Payment,
Acquisition
Date:
8/25/21,
Cost $—  (1)(2)(3)
1,746,361‌
829‌
Vividion
Therapeutics,
Milestone
Payment
3,
Acquisition
Date:
8/25/21,
Cost $—  (1)(2)(3)
1,746,361‌
747‌
Xencor  (1)
762,860‌
19,865‌
Zai
Lab,
ADR  (1)
438,090‌
13,449‌
T.
ROWE
PRICE
Health
Sciences
Fund
19
Shares
$
Value
(Cost
and
value
in
$000s)
Zentalis
Pharmaceuticals  (1)
582,982‌
11,741‌
2,788,043‌
Total
Biotechnology
3,580,774‌
CONSUMER
NONDURABLES
0.0%
Healthcare
Services
0.0%
Capsule,
Acquisition
Date:
4/7/21,
Cost $12,365  (1)(2)(3)
853,213‌
2,501‌
Total
Consumer
Nondurables
2,501‌
LIFE
SCIENCES
13.1%
Life
Sciences
13.1%
Agilent
Technologies 
2,165,312‌
324,039‌
Bio-Techne 
437,137‌
36,230‌
Bruker 
1,913,218‌
130,768‌
Danaher 
2,316,190‌
614,763‌
Dynamics
Special
Purpose,
Acquisition
Date:
12/20/21,
Cost $—  (1)(3)
115,996‌
155‌
Ginkgo
Bioworks
Holdings,
Class
A  (1)
2,329,124‌
3,936‌
Mettler-Toledo
International  (1)
50,097‌
72,413‌
Olink
Holding,
ADR  (1)
1,944,081‌
49,341‌
Pacific
Biosciences
of
California  (1)
2,592,999‌
21,211‌
Quanterix  (1)
114,664‌
1,588‌
Rapid
Micro
Biosystems,
Class
A  (1)
583,246‌
659‌
Seer  (1)
939,085‌
5,447‌
Senti
Biosciences  (1)
1,266,785‌
1,786‌
SomaLogic,
Warrants,
8/31/26  (1)
103,068‌
41‌
SomaLogic,
Earn
Out
Shares
$20,
Acquisition
Date:
9/2/21,
Cost $—  (1)(3)
3,873,442‌
14‌
Thermo
Fisher
Scientific 
1,503,088‌
827,736‌
Twist
Bioscience  (1)
298,281‌
7,102‌
Waters  (1)
64,820‌
22,206‌
Total
Life
Sciences
2,119,435‌
MISCELLANEOUS
0.0%
Miscellaneous
0.0%
Health
Sciences
Acquisitions
Corp
2  (1)
562,163‌
5,616‌
Total
Miscellaneous
5,616‌
PHARMACEUTICALS
16.9%
Major
Pharmaceuticals
16.9%
AbbVie 
1,721,272‌
278,175‌
AstraZeneca,
ADR 
7,999,227‌
542,348‌
Daiichi
Sankyo
(JPY) 
3,945,400‌
126,989‌
Eli
Lilly 
1,981,704‌
724,987‌
Merck 
5,109,928‌
566,946‌
Pfizer 
7,123,092‌
364,987‌
T.
ROWE
PRICE
Health
Sciences
Fund
20
Shares
$
Value
(Cost
and
value
in
$000s)
Roche
Holding
(CHF) 
392,064‌
123,201‌
Total
Pharmaceuticals
2,727,633‌
PRODUCTS
&
DEVICES
16.1%
Capital
Equipment
0.5%
GE
HealthCare
Technologies  (1)
177,056‌
10,337‌
PROCEPT
BioRobotics  (1)
668,997‌
27,790‌
STERIS 
223,989‌
41,368‌
79,495‌
Implants
8.1%
Becton
Dickinson
&
Company 
1,138,233‌
289,453‌
Intuitive
Surgical  (1)
1,809,297‌
480,097‌
iRhythm
Technologies  (1)
180,858‌
16,941‌
Stryker 
1,500,949‌
366,967‌
Teleflex 
310,808‌
77,587‌
Verily
Life
Sciences,
Series
B,
Acquisition
Date:
1/23/19,
Cost $13,998  (1)(2)(3)
113,564‌
17,108‌
Zimmer
Biomet
Holdings 
447,573‌
57,066‌
1,305,219‌
Other
Products
&
Devices
7.5%
10X
Genomics,
Class
A  (1)
1,243,729‌
45,322‌
Argenx,
ADR  (1)
708,841‌
268,530‌
Avantor  (1)
4,213,720‌
88,867‌
Burning
Rock
Biotech,
ADR  (1)
187,049‌
421‌
Catalent  (1)
958,897‌
43,160‌
Cooper 
108,118‌
35,751‌
Dexcom  (1)
1,148,997‌
130,113‌
Hologic  (1)
1,954,618‌
146,225‌
Inari
Medical  (1)
382,006‌
24,280‌
Insulet  (1)
432,380‌
127,288‌
Lantheus
Holdings  (1)
126,300‌
6,436‌
Nevro  (1)
176,893‌
7,005‌
Pax
Labs,
Class
A,
Acquisition
Date:
4/18/19,
Cost $31,622  (1)(2)
(3)
8,397,988‌
5,543‌
Penumbra (1)
667,835‌
148,567‌
Saluda
Medical,
Warrants,
1/1/23,
Acquisition
Date:
1/20/22,
Cost $—  (1)(2)(3)
207,185‌
—‌
Shockwave
Medical  (1)
551,682‌
113,431‌
Warby
Parker,
Class
A  (1)
1,562,906‌
21,084‌
1,212,023‌
Total
Products
&
Devices
2,596,737‌
T.
ROWE
PRICE
Health
Sciences
Fund
21
Shares
$
Value
(Cost
and
value
in
$000s)
SERVICES
21.8%
Distribution
0.1%
Option
Care
Health  (1)
622,214‌
18,722‌
18,722‌
Information
0.9%
Doximity,
Class
A  (1)
1,255,648‌
42,140‌
Sema4
Holdings  (1)
1,150,482‌
303‌
Sema4
Holdings,
Warrants,
7/22/26  (1)
236,011‌
4‌
Sophia
Genetics  (1)
635,323‌
1,309‌
Veeva
Systems,
Class
A  (1)
579,779‌
93,565‌
137,321‌
Other
Services
0.9%
Certara (1)
461,617‌
7,418‌
Elanco
Animal
Health  (1)
625,900‌
7,648‌
Guardant
Health  (1)
1,092,484‌
29,716‌
West
Pharmaceutical
Services 
348,364‌
81,987‌
Wuxi
Biologics
Cayman
(HKD)  (1)
3,159,500‌
23,930‌
150,699‌
Payors
18.8%
Alignment
Healthcare  (1)
1,216,902‌
14,311‌
Centene  (1)
3,321,294‌
272,379‌
Cigna 
711,926‌
235,890‌
Elevance
Health 
995,033‌
510,422‌
Humana 
701,570‌
359,337‌
Molina
Healthcare  (1)
759,446‌
250,784‌
UnitedHealth
Group 
2,644,430‌
1,402,024‌
3,045,147‌
Providers
1.1%
agilon
health  (1)
462,354‌
7,462‌
HCA
Healthcare 
608,498‌
146,015‌
Oak
Street
Health  (1)
512,163‌
11,017‌
Surgery
Partners  (1)
322,715‌
8,991‌
173,485‌
Total
Services
3,525,374‌
Total
Miscellaneous
Common
Stocks
 4.2%  (4)
672,525‌
Total
Common
Stocks
(Cost
$7,580,839)
15,230,595‌
T.
ROWE
PRICE
Health
Sciences
Fund
22
Shares
$
Value
(Cost
and
value
in
$000s)
CONVERTIBLE
PREFERRED
STOCKS
4.4%
BIOTECHNOLOGY
1.4%
Other
Biotechnology
1.4%
Arbor
Bio,
Series
B,
Acquisition
Date:
10/29/21,
Cost $8,828  (1)
(2)(3)
532,759‌
8,828‌
Chroma
Medicine,
Series
A,
Acquisition
Date:
10/12/21,
Cost $11,040  (1)(2)(3)(5)
5,207,526‌
11,040‌
Delfi
Diagnostics,
Series
A,
Acquisition
Date:
1/12/21-4/7/22,
Cost $7,107  (1)(2)(3)
3,426,868‌
16,605‌
Delfi
Diagnostics,
Series
B,
Acquisition
Date:
6/10/22,
Cost $8,980  (1)(2)(3)
1,853,138‌
8,980‌
Eikon
Therapeutics,
Series
B,
Acquisition
Date:
12/3/21,
Cost $18,021  (1)(2)(3)
1,018,820‌
18,022‌
EndeavorBio,
Series
B,
Acquisition
Date:
1/21/22,
Cost $8,808  (1)
(2)(3)
1,867,734‌
8,808‌
FOG
Pharma,
Acquisition
Date:
11/17/22,
Cost $6,621  (1)(2)(3)
615,203‌
6,621‌
FOG
Pharma,
Series
C,
Acquisition
Date:
1/11/21-8/2/21,
Cost $6,251  (1)(2)(3)
431,391‌
4,643‌
Generate
Bio,
Series
B,
Acquisition
Date:
9/2/21,
Cost $22,096  (1)
(2)(3)
1,864,632‌
22,096‌
Genesis
Therapeutics,
Series
A,
Acquisition
Date:
11/24/20,
Cost $4,236  (1)(2)(3)
829,412‌
4,236‌
Insitro,
Series
B,
Acquisition
Date:
5/21/20,
Cost $5,505  (1)(2)(3)
883,580‌
16,162‌
Insitro,
Series
C,
Acquisition
Date:
4/7/21,
Cost $10,762  (1)(2)(3)
588,382‌
10,762‌
Laronde,
Series
B,
Acquisition
Date:
7/28/21,
Cost $32,757  (1)(2)
(3)
1,169,887‌
6,551‌
Nutcracker
Therapeutics,
Series
C,
Acquisition
Date:
8/27/21,
Cost $11,050  (1)(2)(3)
1,027,785‌
11,050‌
Odyssey
Therapeutics,
Series
B,
Acquisition
Date:
5/13/22,
Cost $7,048  (1)(2)(3)
1,115,915‌
7,048‌
Ring
Therapeutics,
Acquisition
Date:
10/7/22,
Cost $4,414  (1)(2)
(3)
479,818‌
4,414‌
Ring
Therapeutics,
Series
B,
Acquisition
Date:
4/12/21,
Cost $9,004  (1)(2)(3)
978,705‌
9,004‌
SalioGen
Therapeutics,
Series
B,
Acquisition
Date:
12/10/21,
Cost $11,024  (1)(2)(3)
104,129‌
11,024‌
Scribe
Therapeutics,
Series
B,
Acquisition
Date:
3/17/21,
Cost $6,219  (1)(2)(3)
1,027,755‌
6,219‌
Sionna
Therapeutics,
Series
B,
Acquisition
Date:
2/2/22,
Cost $5,284  (1)(2)(3)
541,277‌
5,284‌
Tessera
Therapeutics,
Series
C,
Acquisition
Date:
2/25/22,
Cost $7,915  (1)(2)(3)
387,032‌
7,915‌
Treeline
Bioscience,
Series
A,
Acquisition
Date:
4/9/21-9/26/22,
Cost $18,552  (1)(2)(3)
2,370,150‌
18,552‌
Total
Biotechnology
223,864‌
T.
ROWE
PRICE
Health
Sciences
Fund
23
Shares
$
Value
(Cost
and
value
in
$000s)
CONSUMER
NONDURABLES
0.2%
Healthcare
Services
0.2%
Color
Health,
Series
D,
Acquisition
Date:
12/17/20,
Cost $11,180  (1)(2)(3)
296,922‌
12,144‌
Color
Health,
Series
D-1,
Acquisition
Date:
1/13/20,
Cost $9,358  (1)(2)(3)
438,696‌
17,942‌
Color
Health,
Series
E,
Acquisition
Date:
10/26/21,
Cost $4,414  (1)
(2)(3)
44,149‌
1,806‌
Total
Consumer
Nondurables
31,892‌
LIFE
SCIENCES
1.1%
Life
Sciences
1.1%
Cellanome,
Series
A,
Acquisition
Date:
12/30/21,
Cost $11,023  (1)
(2)(3)(5)
1,993,387‌
13,874‌
Chromacode,
Series
D-1,
Acquisition
Date:
2/28/22,
Cost $2,202  (1)(2)(3)
3,137,582‌
2,040‌
Chromacode,
Series
D-2,
Acquisition
Date:
2/28/22,
Cost $2,202  (1)(2)(3)
2,605,184‌
1,693‌
Clear
Labs,
Series
C,
Acquisition
Date:
5/13/21,
Cost $13,294  (1)
(2)(3)
3,830,773‌
13,294‌
DNA
Script,
Series
C,
Acquisition
Date:
12/16/21,
Cost $21,371
(EUR)  (1)(2)(3)
25,201‌
20,232‌
Element
Biosciences,
Series
C,
Acquisition
Date:
6/21/21,
Cost $17,704  (1)(2)(3)
861,217‌
17,704‌
Inscripta,
Series
E,
Acquisition
Date:
3/30/21,
Cost $12,829  (1)(2)
(3)
1,452,941‌
8,107‌
Lumicks
Tech,
Series
D,
Acquisition
Date:
4/14/21,
Cost $8,875  (1)(2)(3)
4,954‌
9,585‌
National
Resilience,
Series
B,
Acquisition
Date:
10/23/20,
Cost $16,458  (1)(2)(3)
1,204,832‌
73,170‌
National
Resilience,
Series
C,
Acquisition
Date:
6/9/21,
Cost $18,957  (1)(2)(3)
426,855‌
25,923‌
Total
Life
Sciences
185,622‌
PRODUCTS
&
DEVICES
0.3%
Capital
Equipment
0.1%
Reflexion
Medical,
Series
C,
Acquisition
Date:
4/3/18,
Cost $4,243  (1)(2)(3)
2,507,885‌
5,945‌
Reflexion
Medical,
Series
D,
Acquisition
Date:
4/3/20,
Cost $2,142  (1)(2)(3)
1,123,437‌
2,663‌
Reflexion
Medical,
Series
E,
Acquisition
Date:
3/1/22,
Cost $4,403  (1)(2)(3)
1,857,286‌
4,403‌
13,011‌
Implants
0.1%
Kardium,
Series
D-5,
Acquisition
Date:
11/29/18,
Cost $8,574  (1)
(2)(3)(5)
8,849,057‌
8,989‌
T.
ROWE
PRICE
Health
Sciences
Fund
24
Shares
$
Value
(Cost
and
value
in
$000s)
Kardium,
Series
D-6,
Acquisition
Date:
1/8/21,
Cost $12,516  (1)
(2)(3)(5)
12,320,393‌
12,516‌
21,505‌
Other
Products
&
Devices
0.1%
Saluda
Medical,
Series
D,
Acquisition
Date:
1/20/22,
Cost $8,809  (1)(2)(3)
690,617‌
8,809‌
8,809‌
Total
Products
&
Devices
43,325‌
SERVICES
1.4%
Information
0.0%
Cleerly,
Series
C,
Acquisition
Date:
7/8/22,
Cost $6,904  (1)(2)(3)
586,029‌
6,904‌
6,904‌
Other
Services
1.3%
Caris
Life
Sciences,
Series
C,
Acquisition
Date:
8/14/20,
Cost $10,374  (1)(2)(3)
3,758,668‌
24,732‌
Caris
Life
Sciences,
Series
D,
Acquisition
Date:
5/11/21,
Cost $18,471  (1)(2)(3)
2,280,334‌
15,005‌
Freenome
Holdings,
Series
B,
Acquisition
Date:
6/24/19,
Cost $7,103  (1)(2)(3)
1,558,570‌
18,189‌
Freenome
Holdings,
Series
C,
Acquisition
Date:
8/14/20,
Cost $6,139  (1)(2)(3)
928,231‌
10,832‌
Freenome
Holdings,
Series
D,
Acquisition
Date:
11/22/21,
Cost $3,971  (1)(2)(3)
526,504‌
6,144‌
PrognomIQ,
Series
A-4,
Acquisition
Date:
11/15/19,
Cost $1,356  (1)(2)(3)(5)
593,540‌
1,816‌
PrognomIQ,
Series
A-5,
Acquisition
Date:
5/12/20,
Cost $1,174  (1)
(2)(3)(5)
513,797‌
1,572‌
PrognomIQ,
Series
B,
Acquisition
Date:
9/11/20,
Cost $8,533  (1)
(2)(3)(5)
3,734,140‌
11,427‌
PrognomIQ,
Series
C,
Acquisition
Date:
2/16/22,
Cost $3,498  (1)
(2)(3)(5)
1,143,244‌
3,498‌
Tempus
Labs,
Series
D,
Acquisition
Date:
3/16/18,
Cost $8,876  (1)
(2)(3)
946,886‌
55,753‌
Tempus
Labs,
Series
E,
Acquisition
Date:
8/23/18,
Cost $10,607  (1)(2)(3)
633,505‌
38,289‌
Tempus
Labs,
Series
F,
Acquisition
Date:
4/30/19,
Cost $4,279  (1)
(2)(3)
172,826‌
10,584‌
Tempus
Labs,
Series
G,
Acquisition
Date:
2/6/20,
Cost $4,285  (1)
(2)(3)
111,715‌
6,924‌
Tempus
Labs,
Series
G-2,
Acquisition
Date:
11/19/20,
Cost $6,720  (1)(2)(3)
117,271‌
6,592‌
211,357‌
T.
ROWE
PRICE
Health
Sciences
Fund
25
Shares
$
Value
(Cost
and
value
in
$000s)
Providers
0.1%
Honor
Technology,
Series
D,
Acquisition
Date:
10/16/20,
Cost $7,540  (1)(2)(3)
3,130,941‌
7,201‌
Honor
Technology,
Series
E,
Acquisition
Date:
9/29/21,
Cost $6,626  (1)(2)(3)
2,095,807‌
4,821‌
12,022‌
Total
Services
230,283‌
Total
Convertible
Preferred
Stocks
(Cost
$538,531)
714,986‌
PREFERRED
STOCKS
0.6%
LIFE
SCIENCES
0.6%
Life
Sciences
0.6%
Sartorius
(EUR) 
240,070‌
94,798‌
Total
Life
Sciences
94,798‌
Total
Preferred
Stocks
(Cost
$46,391)
94,798‌
SHORT-TERM
INVESTMENTS
1.0%
Money
Market
Funds
1.0%
T.
Rowe
Price
Government
Reserve
Fund,
4.30%  (5)(6)
158,975,596‌
158,976‌
Total
Short-Term
Investments
(Cost
$158,976)
158,976‌
Total
Investments
in
Securities
100.2%
of
Net
Assets
(Cost
$8,324,737)
$
16,199,355‌
Shares
are
denominated
in
U.S.
dollars
unless
otherwise
noted.
(1)
Non-income
producing
(2)
See
Note
2.
Level
3
in
fair
value
hierarchy.
(3)
Security
cannot
be
offered
for
public
resale
without
first
being
registered
under
the
Securities
Act
of
1933
and
related
rules
("restricted
security").
Acquisition
date
represents
the
day
on
which
an
enforceable
right
to
acquire
such
security
is
obtained
and
is
presented
along
with
related
cost
in
the
security
description.
The
fund
may
have
registration
rights
for
certain
restricted
securities.
Any
costs
related
to
such
registration
are
generally
borne
by
the
issuer.
The
aggregate
value
of
restricted
securities
(excluding
144A
holdings)
at
period
end
amounts
to
$785,328
and
represents
4.9%
of
net
assets.
(4)
The
identity
of
certain
securities
has
been
concealed
to
protect
the
fund
while
it
completes
a
purchase
or
selling
program
for
the
securities.
(5)
Affiliated
Companies
(6)
Seven-day
yield
T.
ROWE
PRICE
Health
Sciences
Fund
26
ADR
American
Depositary
Receipts
CHF
Swiss
Franc
CVR
Contingent
Value
Rights
DKK
Danish
Krone
EC
Escrow
CUSIP;
represents
a
beneficial
interest
in
a
residual
pool
of
assets;
the
amount
and
timing
of
future
distributions,
if
any,
is
uncertain;
when
presented,
interest
rate
and
maturity
date
are
those
of
the
original
security.
EUR
Euro
HKD
Hong
Kong
Dollar
JPY
Japanese
Yen
T.
ROWE
PRICE
Health
Sciences
Fund
27
AFFILIATED
COMPANIES
($000s)
The
fund
may
invest
in
certain
securities
that
are
considered
affiliated
companies.
As
defined
by
the
1940
Act,
an
affiliated
company
is
one
in
which
the
fund
owns
5%
or
more
of
the
outstanding
voting
securities,
or
a
company
that
is
under
common
ownership
or
control.
The
following
securities
were
considered
affiliated
companies
for
all
or
some
portion
of
the
year
ended
December
31,
2022.
Net
realized
gain
(loss),
investment
income,
change
in
net
unrealized
gain/loss,
and
purchase
and
sales
cost
reflect
all
activity
for
the
period
then
ended.
Affiliate
Net
Realized
Gain
(Loss)
Change
in
Net
Unrealized
Gain/Loss
Investment
Income
Cellanome,
Series
$
—‌
$
2,851‌
$
—‌
Chroma
Medicine,
Series
—‌
—‌
—‌
Immuneering,
Class
(1,127‌)
(6,145‌)
—‌
Kardium,
Series
D-5 
—‌
—‌
—‌
Kardium,
Series
D-6 
—‌
—‌
—‌
PrognomIQ,
Series
A-4 
—‌
459‌
—‌
PrognomIQ,
Series
A-5 
—‌
398‌
—‌
PrognomIQ,
Series
—‌
2,894‌
—‌
PrognomIQ,
Series
—‌
—‌
—‌
SomaLogic,
Warrants,
8/31/26 
(22‌)
(305‌)
—‌
SomaLogic,
Earn
Out
Shares
$20 
—‌
(368‌)
—‌
Treeline
Bioscience,
Series
—‌
—‌
—‌
T.
Rowe
Price
Government
Reserve
Fund,
4.30%
—‌
—‌
385‌
Affiliates
not
held
at
period
end
(4,554‌)
(29,640‌)
—‌
Totals
$
(5,703‌)#
$
(29,856‌)
$
385‌+
T.
ROWE
PRICE
Health
Sciences
Fund
28
The
accompanying
notes
are
an
integral
part
of
these
financial
statements.
AFFILIATED
COMPANIES
(CONTINUED)
($000s)
Supplementary
Investment
Schedule
Affiliate
Value
12/31/21
Purchase
Cost
Sales
Cost
Value
12/31/22
Cellanome,
Series
$
11,023‌
$
—‌
$
—‌
$
13,874‌
Chroma
Medicine,
Series
11,040‌
—‌
—‌
11,040‌
Immuneering,
Class
*
9,467‌
2,140‌
*
Kardium,
Series
D-5 
8,989‌
—‌
—‌
8,989‌
Kardium,
Series
D-6 
12,516‌
—‌
—‌
12,516‌
PrognomIQ,
Series
A-4 
1,357‌
—‌
—‌
1,816‌
PrognomIQ,
Series
A-5 
1,174‌
—‌
—‌
1,572‌
PrognomIQ,
Series
8,533‌
—‌
—‌
11,427‌
PrognomIQ,
Series
—‌
3,498‌
—‌
3,498‌
SomaLogic 
14,966‌
15,668‌
28,159‌
—‌
SomaLogic,
Warrants,
8/31/26 
372‌
—‌
26‌
*
SomaLogic,
Class
42,833‌
—‌
15,668‌
—‌
SomaLogic,
Earn
Out
Shares
$20 
382‌
—‌
—‌
*
Treeline
Bioscience,
Series
*
11,332‌
—‌
*
T.
Rowe
Price
Government
Reserve
Fund,
4.30%
12,084‌
  ¤
  ¤
158,976‌
Total
$
223,708‌^
#
Capital
gain
distributions
from
underlying
Price
funds
represented
$0
of
the
net
realized
gain
(loss).
+
Investment
income
comprised
$385
of
dividend
income
and
$0
of
interest
income.
¤
Purchase
and
sale
information
not
shown
for
cash
management
funds.
^
The
cost
basis
of
investments
in
affiliated
companies
was
$216,690.
*
On
the
date
indicated,
issuer
was
held
but
not
considered
an
affiliated
company.
T.
ROWE
PRICE
Health
Sciences
Fund
December
31,
2022
Statement
of
Assets
and
Liabilities
29
($000s,
except
shares
and
per
share
amounts)
The
accompanying
notes
are
an
integral
part
of
these
financial
statements.
Assets
Investments
in
securities,
at
value
(cost
$8,324,737)
$
16,199,355‌
Receivable
for
investment
securities
sold
19,602‌
Receivable
for
shares
sold
9,592‌
Dividends
receivable
6,753‌
Foreign
currency
(cost
$590)
599‌
Other
assets
5,302‌
Total
assets
16,241,203‌
Liabilities
Payable
for
shares
redeemed
39,430‌
Payable
for
investment
securities
purchased
17,387‌
Investment
management
fees
payable
8,914‌
Due
to
affiliates
796‌
Payable
to
directors
10‌
Other
liabilities
1,675‌
Total
liabilities
68,212‌
NET
ASSETS
$
16,172,991‌
Net
Assets
Consist
of:
Total
distributable
earnings
(loss)
$
7,680,227‌
Paid-in
capital
applicable
to
179,996,928
shares
of
$0.0001
par
value
capital
stock
outstanding;
1,000,000,000
shares
authorized
8,492,764‌
NET
ASSETS
$
16,172,991‌
NET
ASSET
VALUE
PER
SHARE
Investor
Class
($10,235,148,927
/
113,952,879
shares
outstanding)
$
89.82‌
I
Class
($5,937,842,426
/
66,044,049
shares
outstanding)
$
89.91‌
T.
ROWE
PRICE
Health
Sciences
Fund
Statement
of
Operations
30
($000s)
The
accompanying
notes
are
an
integral
part
of
these
financial
statements.
Year
Ended
12/31/22
Investment
Income
(Loss)
Income
Dividend
(net
of
foreign
taxes
of
$1,385)
$
115,915‌
Other
9‌
Total
income
115,924‌
Expenses
Investment
management
103,891‌
Shareholder
servicing
Investor
Class
$
17,099‌
I
Class
1,254‌
18,353‌
Prospectus
and
shareholder
reports
Investor
Class
341‌
I
Class
46‌
387‌
Custody
and
accounting
586‌
Legal
and
audit
292‌
Registration
216‌
Directors
43‌
Miscellaneous
438‌
Total
expenses
124,206‌
Net
investment
loss
(8,282‌)
T.
ROWE
PRICE
Health
Sciences
Fund
Statement
of
Operations
31
($000s)
The
accompanying
notes
are
an
integral
part
of
these
financial
statements.
Year
Ended
12/31/22
Realized
and
Unrealized
Gain
/
Loss
Net
realized
gain
(loss)
Securities
(13,937‌)
Foreign
currency
transactions
(660‌)
Net
realized
loss
(14,597‌)
Change
in
net
unrealized
gain
/
loss
Securities
(2,384,200‌)
Other
assets
and
liabilities
denominated
in
foreign
currencies
(61‌)
Change
in
net
unrealized
gain
/
loss
(2,384,261‌)
Net
realized
and
unrealized
gain
/
loss
(2,398,858‌)
DECREASE
IN
NET
ASSETS
FROM
OPERATIONS
$
(2,407,140‌)
T.
ROWE
PRICE
Health
Sciences
Fund
Statement
of
Changes
in
Net
Assets
32
($000s)
Year
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
Ended
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
12/31/22
12/31/21
Increase
(Decrease)
in
Net
Assets
Operations
Net
investment
loss
$
(8,282‌)
$
(37,152‌)
Net
realized
gain
(loss)
(14,597‌)
1,251,022‌
Change
in
net
unrealized
gain
/
loss
(2,384,261‌)
1,085,757‌
Increase
(decrease)
in
net
assets
from
operations
(2,407,140‌)
2,299,627‌
Distributions
to
shareholders
Net
earnings
Investor
Class
(179,171‌)
(1,202,597‌)
I
Class
(103,404‌)
(161,546‌)
Decrease
in
net
assets
from
distributions
(282,575‌)
(1,364,143‌)
Capital
share
transactions
*
Shares
sold
Investor
Class
1,236,166‌
1,935,820‌
I
Class
4,332,246‌
667,635‌
Distributions
reinvested
Investor
Class
172,182‌
1,144,471‌
I
Class
97,063‌
155,182‌
Shares
redeemed
Investor
Class
(5,916,581‌)
(2,473,973‌)
I
Class
(567,212‌)
(287,745‌)
Increase
(decrease)
in
net
assets
from
capital
share
transactions
(646,136‌)
1,141,390‌
T.
ROWE
PRICE
Health
Sciences
Fund
Statement
of
Changes
in
Net
Assets
33
($000s)
The
accompanying
notes
are
an
integral
part
of
these
financial
statements.
Year
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
Ended
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
12/31/22
12/31/21
Net
Assets
Increase
(decrease)
during
period
(3,335,851‌)
2,076,874‌
Beginning
of
period
19,508,842‌
17,431,968‌
End
of
period
$
16,172,991‌
$
19,508,842‌
*Share
information
(000s)
Shares
sold
Investor
Class
13,681‌
18,329‌
I
Class
49,285‌
6,269‌
Distributions
reinvested
Investor
Class
1,895‌
11,183‌
I
Class
1,067‌
1,517‌
Shares
redeemed
Investor
Class
(67,007‌)
(23,488‌)
I
Class
(6,369‌)
(2,712‌)
Increase
(decrease)
in
shares
outstanding
(7,448‌)
11,098‌
T.
ROWE
PRICE
Health
Sciences
Fund
NOTES
TO
FINANCIAL
STATEMENTS
34
T.
Rowe
Price
Health
Sciences
Fund,
Inc.
(the
fund) is
registered
under
the
Investment
Company
Act
of
1940
(the
1940
Act)
as a
diversified,
open-end
management
investment
company. The
fund
seeks
long-term
capital
appreciation.
The
fund
has
two classes
of
shares:
the
Health
Sciences
Fund
(Investor
Class)
and
the
Health
Sciences
Fund–I
Class
(I
Class).
I
Class
shares
require
a
$500,000
initial
investment
minimum,
although
the
minimum
generally
is
waived
or
reduced
for
financial
intermediaries,
eligible
retirement
plans,
and
certain
other
accounts.
Prior
to
November
15,
2021,
the
initial
investment
minimum
was
$1
million
and
was
generally
waived
for
financial
intermediaries,
eligible
retirement
plans,
and
other
certain
accounts.
As
a
result
of
the
reduction
in
the
I
Class
minimum,
certain
assets
transferred
from
the
Investor
Class
to
the
I
Class.
This
transfer
of
shares
from
Investor
Class
to
I
Class
is
reflected
in
the
Statement
of
Changes
in
Net
Assets
within
the
Capital
shares
transactions
as
Shares
redeemed
and
Shares
sold,
respectively. Each
class
has
exclusive
voting
rights
on
matters
related
solely
to
that
class;
separate
voting
rights
on
matters
that
relate
to
both
classes;
and,
in
all
other
respects,
the
same
rights
and
obligations
as
the
other
class.
NOTE
1
-
SIGNIFICANT
ACCOUNTING
POLICIES 
Basis
of
Preparation
 The fund
is
an
investment
company
and
follows
accounting
and
reporting
guidance
in
the
Financial
Accounting
Standards
Board
(FASB)
Accounting
Standards
Codification
Topic
946
(ASC
946).
The
accompanying
financial
statements
were
prepared
in
accordance
with
accounting
principles
generally
accepted
in
the
United
States
of
America
(GAAP),
including,
but
not
limited
to,
ASC
946.
GAAP
requires
the
use
of
estimates
made
by
management.
Management
believes
that
estimates
and
valuations
are
appropriate;
however,
actual
results
may
differ
from
those
estimates,
and
the
valuations
reflected
in
the
accompanying
financial
statements
may
differ
from
the
value
ultimately
realized
upon
sale
or
maturity.
Investment
Transactions,
Investment
Income,
and
Distributions
Investment
transactions
are
accounted
for
on
the
trade
date
basis.
Income
and
expenses
are
recorded
on
the
accrual
basis.
Realized
gains
and
losses
are
reported
on
the
identified
cost
basis.
Income
tax-related
interest
and
penalties,
if
incurred,
are
recorded
as
income
tax
expense.
Dividends
received
from
mutual
fund
investments
are
reflected
as
dividend
income;
capital
gain
distributions
are
reflected
as
realized
gain/loss.
Dividend
income
and
capital
gain
distributions
are
recorded
on
the
ex-dividend
date.
Non-cash
dividends,
if
any,
are
recorded
at
the
fair
market
value
of
the
asset
received.
Proceeds
from
litigation
payments,
if
any,
are
included
in
either
net
realized
gain
(loss)
or
change
T.
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Health
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35
in
net
unrealized
gain/loss
from
securities.
Distributions
to
shareholders
are
recorded
on
the
ex-dividend
date.
Income
distributions,
if
any,
are
declared
and
paid
by
each
class annually.
A
capital
gain
distribution,
if
any, may
also
be
declared
and
paid
by
the
fund
annually.
Currency
Translation
 Assets,
including
investments,
and
liabilities
denominated
in
foreign
currencies
are
translated
into
U.S.
dollar
values
each
day
at
the
prevailing
exchange
rate,
using
the
mean
of
the
bid
and
asked
prices
of
such
currencies
against
U.S.
dollars
as
provided
by
an
outside
pricing
service.
Purchases
and
sales
of
securities,
income,
and
expenses
are
translated
into
U.S.
dollars
at
the
prevailing
exchange
rate
on
the
respective
date
of
such
transaction.
The
effect
of
changes
in
foreign
currency
exchange
rates
on
realized
and
unrealized
security
gains
and
losses
is
not
bifurcated
from
the
portion
attributable
to
changes
in
market
prices.
Class
Accounting
 Shareholder
servicing,
prospectus,
and
shareholder
report
expenses
incurred
by
each
class
are
charged
directly
to
the
class
to
which
they
relate.
Expenses
common
to all classes,
investment
income,
and
realized
and
unrealized
gains
and
losses
are
allocated
to
the
classes
based
upon
the
relative
daily
net
assets
of
each
class.
Capital
Transactions
 Each
investor’s
interest
in
the
net
assets
of the
fund
is
represented
by
fund
shares. The
fund’s
net
asset
value
(NAV)
per
share
is
computed
at
the
close
of
the
New
York
Stock
Exchange
(NYSE),
normally
4
p.m.
ET,
each
day
the
NYSE
is
open
for
business.
However,
the
NAV
per
share
may
be
calculated
at
a
time
other
than
the
normal
close
of
the
NYSE
if
trading
on
the
NYSE
is
restricted,
if
the
NYSE
closes
earlier,
or
as
may
be
permitted
by
the
SEC.
Purchases
and
redemptions
of
fund
shares
are
transacted
at
the
next-computed
NAV
per
share,
after
receipt
of
the
transaction
order
by
T.
Rowe
Price
Associates,
Inc.,
or
its
agents.
New
Accounting
Guidance
 In
June
2022,
the
FASB
issued
Accounting
Standards
Update
(ASU),
ASU
2022-03,
Fair
Value
Measurement
(Topic
820)
Fair
Value
Measurement
of
Equity
Securities
Subject
to
Contractual
Sale
Restrictions,
which
clarifies
that
a
contractual
restriction
on
the
sale
of
an
equity
security
is
not
considered
part
of
the
unit
of
account
of
the
equity
security
and,
therefore,
is
not
considered
in
measuring
fair
value.
The
amendments
under
this
ASU
are
effective
for
fiscal
years
beginning
after
December
15,
2023;
however,
the
fund
opted
to
early
adopt,
as
permitted,
effective
December
1,
2022. Adoption
of
the
guidance
did not
have
a
material
impact
on
the fund's
financial  statements.
Indemnification
 In
the
normal
course
of
business, the
fund
may
provide
indemnification
in
connection
with
its
officers
and
directors,
service
providers,
and/or
private
company
investments. The
fund’s
maximum
exposure
under
these
arrangements
is
unknown;
however,
the
risk
of
material
loss
is
currently
considered
to
be
remote.
T.
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Health
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36
NOTE
2
-
VALUATION 
Fair
Value
  The
fund’s
financial
instruments
are
valued
at
the
close
of
the
NYSE
and
are
reported
at
fair
value,
which
GAAP
defines
as
the
price
that
would
be
received
to
sell
an
asset
or
paid
to
transfer
a
liability
in
an
orderly
transaction
between
market
participants
at
the
measurement
date. The fund’s
Board
of
Directors
(the
Board)
has
designated
T.
Rowe
Price
Associates,
Inc.
as
the
fund’s
valuation
designee
(Valuation
Designee).
Subject
to
oversight
by
the
Board,
the
Valuation
Designee
performs
the
following
functions
in
performing
fair
value
determinations:
assesses
and
manages
valuation
risks;
establishes
and
applies
fair
value
methodologies;
tests
fair
value
methodologies;
and
evaluates
pricing
vendors
and
pricing
agents.
The
duties
and
responsibilities
of
the
Valuation
Designee
are
performed
by
its
Valuation
Committee. The
Valuation
Designee provides
periodic
reporting
to
the
Board
on
valuation
matters.
Various
valuation
techniques
and
inputs
are
used
to
determine
the
fair
value
of
financial
instruments.
GAAP
establishes
the
following
fair
value
hierarchy
that
categorizes
the
inputs
used
to
measure
fair
value:
Level
1
quoted
prices
(unadjusted)
in
active
markets
for
identical
financial
instruments
that
the
fund
can
access
at
the
reporting
date
Level
2
inputs
other
than
Level
1
quoted
prices
that
are
observable,
either
directly
or
indirectly
(including,
but
not
limited
to,
quoted
prices
for
similar
financial
instruments
in
active
markets,
quoted
prices
for
identical
or
similar
financial
instruments
in
inactive
markets,
interest
rates
and
yield
curves,
implied
volatilities,
and
credit
spreads)
Level
3
unobservable
inputs
(including
the Valuation
Designee’s assumptions
in
determining
fair
value)
Observable
inputs
are
developed
using
market
data,
such
as
publicly
available
information
about
actual
events
or
transactions,
and
reflect
the
assumptions
that
market
participants
would
use
to
price
the
financial
instrument.
Unobservable
inputs
are
those
for
which
market
data
are
not
available
and
are
developed
using
the
best
information
available
about
the
assumptions
that
market
participants
would
use
to
price
the
financial
instrument.
GAAP
requires
valuation
techniques
to
maximize
the
use
of
relevant
observable
inputs
and
minimize
the
use
of
unobservable
inputs.
When
multiple
inputs
are
used
to
derive
fair
value,
the
financial
instrument
is
assigned
to
the
level
within
the
fair
value
hierarchy
based
on
the
lowest-level
input
that
is
significant
to
the
fair
value
of
the
financial
instrument.
Input
levels
are
not
necessarily
an
indication
of
the
risk
or
liquidity
associated
with
financial
instruments
at
that
level
but
rather
the
degree
of
judgment
used
in
determining
those
values.
T.
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Health
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Fund
37
Valuation
Techniques 
Equity
securities,
including
exchange-traded
funds, listed
or
regularly
traded
on
a
securities
exchange
or
in
the
over-the-counter
(OTC)
market
are
valued
at
the
last
quoted
sale
price
or,
for
certain
markets,
the
official
closing
price
at
the
time
the
valuations
are
made.
OTC
Bulletin
Board
securities
are
valued
at
the
mean
of
the
closing
bid
and
asked
prices.
A
security
that
is
listed
or
traded
on
more
than
one
exchange
is
valued
at
the
quotation
on
the
exchange
determined
to
be
the
primary
market
for
such
security.
Listed
securities
not
traded
on
a
particular
day
are
valued
at
the
mean
of
the
closing
bid
and
asked
prices
for
domestic
securities
and
the
last
quoted
sale
or
closing
price
for
international
securities.
The
last
quoted
prices
of
non-U.S.
equity
securities
may
be
adjusted
to
reflect
the
fair
value
of
such
securities
at
the
close
of
the
NYSE,
if
the Valuation
Designee
determines
that
developments
between
the
close
of
a
foreign
market
and
the
close
of
the
NYSE
will
affect
the
value
of
some
or
all
of the
fund’s
portfolio
securities.
Each
business
day,
the
Valuation
Designee uses
information
from
outside
pricing
services
to
evaluate
the
quoted
prices
of
portfolio
securities
and,
if
appropriate,
decide whether
it
is
necessary
to
adjust
quoted
prices
to
reflect
fair
value
by
reviewing
a
variety
of
factors,
including
developments
in
foreign
markets,
the
performance
of
U.S.
securities
markets,
and
the
performance
of
instruments
trading
in
U.S.
markets
that
represent
foreign
securities
and
baskets
of
foreign
securities. The Valuation
Designee
uses
outside
pricing
services
to
provide
it
with
quoted
prices
and
information
to
evaluate
or
adjust
those
prices.
The Valuation
Designee
cannot
predict
how
often
it
will
use
quoted
prices
and
how
often
it
will
determine
it
necessary
to
adjust
those
prices
to
reflect
fair
value.
Investments
in
mutual
funds
are
valued
at
the
mutual
fund’s
closing
NAV
per
share
on
the
day
of
valuation.
Assets
and
liabilities
other
than
financial
instruments,
including
short-term
receivables
and
payables,
are
carried
at
cost,
or
estimated
realizable
value,
if
less,
which
approximates
fair
value. 
Investments
for
which
market
quotations are
not
readily
available
or
deemed
unreliable
are
valued
at
fair
value
as
determined
in
good
faith
by
the
Valuation
Designee.
The
Valuation
Designee
has
adopted
methodologies
for
determining
the
fair
value
of
investments
for
which
market
quotations
are
not
readily
available
or
deemed
unreliable,
including
the
use
of
other
pricing
sources.
Factors
used
in
determining
fair
value
vary
by
type
of
investment
and
may
include
market
or
investment
specific
considerations.
The
Valuation
Designee typically
will
afford
greatest
weight
to
actual
prices
in
arm’s
length
transactions,
to
the
extent
they
represent
orderly
transactions
between
market
participants,
transaction
information
can
be
reliably
obtained,
and
prices
are
deemed
representative
of
fair
value.
However,
the
Valuation
Designee may
also
consider
other
valuation
methods
such
as
market-based
valuation
multiples;
a
discount
or
premium
from
market
value
of
a
similar,
freely
traded
security
of
the
same
issuer;
discounted
cash
T.
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Health
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Fund
38
flows;
yield
to
maturity;
or
some
combination.
Fair
value
determinations
are
reviewed
on
a
regular
basis.
Because
any
fair
value
determination
involves
a
significant
amount
of
judgment,
there
is
a
degree
of
subjectivity
inherent
in
such
pricing
decisions. Fair
value
prices
determined
by
the
Valuation
Designee could
differ
from
those
of
other
market
participants,
and
it
is
possible
that
the
fair
value
determined
for
a
security
may
be
materially
different
from
the
value
that
could
be
realized
upon
the
sale
of
that
security.
Valuation
Inputs
  The
following
table
summarizes
the
fund’s
financial
instruments,
based
on
the
inputs
used
to
determine
their
fair
values
on
December
31,
2022
(for
further
detail
by
category,
please
refer
to
the
accompanying
Portfolio
of
Investments):
Following
is
a
reconciliation
of
the
fund’s
Level
3
holdings
for
the
year ended
December
31,
2022.
Gain
(loss)
reflects
both
realized
and
change
in
unrealized
gain/
loss
on
Level
3
holdings
during
the
period,
if
any,
and
is
included
on
the
accompanying
Statement
of
Operations.
The
change
in
unrealized
gain/loss
on
Level
3
instruments
held
at
December
31,
2022,
totaled $(54,912,000) for
the
year ended
December
31,
2022.
o
In
accordance
with
GAAP,
the
following
table
provides
quantitative
information
about
significant
unobservable
inputs
used
to
determine
the
fair
valuations
of
the
fund’s
Level
3
assets,
by
class
of
financial
instrument.
Because
the
Valuation
Designee
considers
($000s)
Level
1
Level
2
Level
3
Total
Value
Assets
Common
Stocks
$
14,720,053‌
$
449,703‌
$
60,839‌
$
15,230,595‌
Convertible
Preferred
Stocks
—‌
—‌
714,986‌
714,986‌
Preferred
Stocks
—‌
94,798‌
—‌
94,798‌
Short-Term
Investments
158,976‌
—‌
—‌
158,976‌
Total
$
14,879,029‌
$
544,501‌
$
775,825‌
$
16,199,355‌
($000s)
Beginning
Balance
12/31/21
Gain
(Loss)
During
Period
Total
Purchases
Total
Sales
Ending
Balance
12/31/22
Investment
in
Securities
Common
Stocks
$
58,155‌
$
(20,956‌)
$
32,547‌
$
(8,907‌)
$
60,839‌
Convertible
Preferred
Stocks
706,485‌
2,198‌
91,063‌
(84,760‌)
714,986‌
Total
$
764,640‌
$
(18,758‌)
$
123,610‌
$
(93,667‌)
$
775,825‌
T.
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Health
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Fund
39
a
wide
variety
of
factors
and
inputs,
both
observable
and
unobservable,
in
determining
fair
values,
the
unobservable
inputs
presented
do
not
reflect
all
inputs
significant
to
the
fair
value
determination.
Investments
in
Securities
Value
(000s)
Valuation
Technique(s)+
Significant
Unobservable
Input(s)
Value
or
Range
of
Input(s)
Weighted
Average
of
Input(s)*
Impact
to
Valuation
from
an
Increase
in
Input**
Common
Stocks
$
60,839‌
Recent
comparable
transaction
price(s)
—#
—#
—#
—#
Discount
for
uncertainty
5%
-
78%
55%
Decrease
Market
comparable
Enterprise
value
to
sales
multiple
2.8x
2.8x
Increase
Enterprise
value
to
gross
profit
multiple
6.0x
6.0x
Increase
Probability
for
alternate
outcome
20%
-
40%
30%
Decrease
Discount
for
lack
of
marketability
10%
10%
Decrease
Expected
present
value
Discount
rate
for
cost
of
equity
12%
-
25%
14%
Decrease
Discount
for
regulatory
uncertainty
29%
-
100%
29%
Decrease
Convertible
Preferred
Stocks
$
714,986‌
Recent
comparable
transaction
price(s)
—#
—#
—#
—#
T.
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Health
Sciences
Fund
40
Investments
in
Securities
Value
(000s)
Valuation
Technique(s)+
Significant
Unobservable
Input(s)
Value
or
Range
of
Input(s)
Weighted
Average
of
Input(s)*
Impact
to
Valuation
from
an
Increase
in
Input**
Premium
for
cumulative
preferred
dividend
rights
3%
-
8%
4%
Increase
Discount
for
cumulative
preferred
dividend
rights
2%
2%
Decrease
Market
comparable
Enterprise
value
to
sales
multiple
2.5x
11.7x
4.9x
Increase
Sales
growth
rate
(58%)
-
266%
13%
Increase
Enterprise
value
to
gross
profit
multiple
8.5x
10.2x
9.4x
Increase
Gross
profit
growth
rate
29%
29%
Increase
Discount
rate
for
cost
of
capital
30%
30%
Decrease
Discount
for
lack
of
marketability
10%
10%
Decrease
Estimated
liquidation
value
Discount
for
lack
of
collectability
100%
100%
Decrease
T.
ROWE
PRICE
Health
Sciences
Fund
41
+
Valuation
techniques
may
change
in
order
to
reflect the
Valuation
Designee’s
judgment
of
current
market
participant
assumptions. 
*
Unobservable
inputs
were
weighted
by
the
relative
fair
value
of
the
instruments.
**
Represents
the
directional
change
in
the
fair
value
of
the
Level
3
investment(s)
that
would
have
resulted
from
an
increase
in
the
corresponding
input
at
period
end.
A
decrease
in
the
unobservable
input
would
have
had
the
opposite
effect.
Significant
increases
and
decreases
in
these
inputs
in
isolation
could
result
in
significantly
higher
or
lower
fair
value
measurements.
#
No
quantitative
unobservable
inputs
significant
to
the
valuation
technique
were
created
by
the
Valuation
Designee.
NOTE
3
-
OTHER
INVESTMENT
TRANSACTIONS 
Consistent
with
its
investment
objective,
the
fund
engages
in
the
following
practices
to
manage
exposure
to
certain
risks
and/or
to
enhance
performance.
The
investment
objective,
policies,
program,
and
risk
factors
of
the
fund
are
described
more
fully
in
the
fund’s
prospectus
and
Statement
of
Additional
Information.
Restricted
Securities
 The
fund
invests
in
securities
that
are
subject
to
legal
or
contractual
restrictions
on
resale.
Prompt
sale
of
such
securities
at
an
acceptable
price
may
be
difficult
and
may
involve
substantial
delays
and
additional
costs.
Private
Investments
Issued
by
Special
Purpose
Acquisition
Companies
Special purpose
acquisition
companies
(SPACs)
are
shell
companies
that
have
no
operations
but
are
formed
to
raise
capital
with
the
intention
of
merging
with
or
acquiring
a
company
with
the
proceeds
of
the
SPAC’s
initial
public
offering
(IPO).
The
fund
may
enter
into
a
contingent
commitment
with
a
SPAC
to
purchase
private
investments
in
public
equity
(PIPE)
if
and
when
the
SPAC
completes
its
merger
or
acquisition.
The
fund
maintains
liquid
assets
sufficient
to
settle
its
commitment
to
purchase
the
PIPE.
However,
if
the
commitment
expires,
then
no
shares
are
purchased.
Purchased
PIPE
shares
will
be
restricted
from
trading
until
the
registration
statement
for
the
shares
is
declared
effective.
Upon
registration,
the
shares
can
be
freely
sold;
however,
in
certain
circumstances,
the
issuer
may
have
the
right
to
temporarily
suspend
trading
of
the
shares
in
the
first
year
after
the
merger
or
acquisition.
The
securities
issued
by
a
SPAC
may
be
considered
illiquid,
more
difficult
to
value,
and/or
be
subject
to
restrictions
on
resale.
Other 
Purchases
and
sales
of
portfolio
securities
other
than
short-term securities
aggregated $4,752,095,000 and
$5,816,314,000,
respectively,
for
the
year ended
December
31,
2022.
T.
ROWE
PRICE
Health
Sciences
Fund
42
NOTE
4
-
FEDERAL
INCOME
TAXES
Generally,
no
provision
for
federal
income
taxes
is
required
since
the
fund
intends
to
continue
to
qualify
as
a
regulated
investment
company
under
Subchapter
M
of
the
Internal
Revenue
Code
and
distribute
to
shareholders
all
of
its
taxable
income
and
gains.
Distributions
determined
in
accordance
with
federal
income
tax
regulations
may
differ
in
amount
or
character
from
net
investment
income
and
realized
gains
for
financial
reporting
purposes.
The fund
files
U.S.
federal,
state,
and
local
tax
returns
as
required. The
fund’s
tax
returns
are
subject
to
examination
by
the
relevant
tax
authorities
until
expiration
of
the
applicable
statute
of
limitations,
which
is
generally
three
years
after
the
filing
of
the
tax
return
but
which
can
be
extended
to
six
years
in
certain
circumstances.
Tax
returns
for
open
years
have
incorporated
no
uncertain
tax
positions
that
require
a
provision
for
income
taxes.
Capital
accounts
within
the
financial
reporting
records
are
adjusted
for
permanent
book/tax
differences
to
reflect
tax
character
but
are
not
adjusted
for
temporary
differences.
The
permanent
book/tax
adjustments,
if
any,
have
no
impact
on
results
of
operations
or
net
assets.
The
permanent
book/tax
adjustments
relate
primarily
to
the
current
net
operating
loss.
The
tax
character
of
distributions
paid
for
the
periods
presented
was
as
follows:
At
December
31,
2022,
the
tax-basis
cost
of
investments
(including
derivatives,
if
any)
and
gross
unrealized
appreciation
and
depreciation
were
as
follows:
($000s)
December
31,
2022
December
31,
2021
Ordinary
income
(including
short-term
capital
gains,
if
any)
$
805‌
$
301,547‌
Long-term
capital
gain
281,770‌
1,062,596‌
Total
distributions
$
282,575‌
$
1,364,143‌
($000s)
Cost
of
investments
$
8,569,479‌
Unrealized
appreciation
$
8,439,370‌
Unrealized
depreciation
(809,411‌)
Net
unrealized
appreciation
(depreciation)
$
7,629,959‌
T.
ROWE
PRICE
Health
Sciences
Fund
43
At
December
31,
2022,
the
tax-basis
components
of
accumulated
net
earnings
(loss)
were
as
follows:
Temporary
differences
between
book-basis
and
tax-basis
components
of
total
distributable
earnings
(loss)
arise
when
certain
items
of
income,
gain,
or
loss
are
recognized
in
different
periods
for
financial
statement
purposes
versus
for
tax
purposes;
these
differences
will
reverse
in
a
subsequent
reporting
period.
The
temporary
differences
relate
primarily
to
the
deferral
of
losses
from
wash
sales
and
the
realization
of
gains/losses
on
passive
foreign
investment
companies.
The
loss
carryforwards
and
deferrals
primarily
relate
to
late-year
ordinary
loss
deferrals. The
fund
has
elected
to
defer
certain
losses
to
the
first
day
of
the
following
fiscal
year
for
late-year
ordinary
loss
deferrals.
NOTE
5
-
FOREIGN  TAXES
The
fund
is
subject
to
foreign
income
taxes
imposed
by
certain
countries
in
which
it
invests.
Additionally,
capital
gains
realized
upon
disposition
of
securities
issued
in
or
by
certain
foreign
countries
are
subject
to
capital
gains
tax
imposed
by
those
countries.
All
taxes
are
computed
in
accordance
with
the
applicable
foreign
tax
law,
and,
to
the
extent
permitted,
capital
losses
are
used
to
offset
capital
gains.
Taxes
attributable
to
income
are
accrued
by
the
fund
as
a
reduction
of
income.
Current
and
deferred
tax
expense
attributable
to
capital
gains
is
reflected
as
a
component
of
realized
or
change
in
unrealized
gain/loss
on
securities
in
the
accompanying
financial
statements.
To
the
extent
that
the
fund
has
country
specific
capital
loss
carryforwards,
such
carryforwards
are
applied
against
net
unrealized
gains
when
determining
the
deferred
tax
liability.
Any
deferred
tax
liability
incurred
by
the
fund
is
included
in
either
Other
liabilities
or
Deferred
tax
liability
on
the
accompanying
Statement
of
Assets
and
Liabilities.
($000s)
Undistributed
long-term
capital
gain
$
56,915‌
Net
unrealized
appreciation
(depreciation)
7,629,959‌
Loss
carryforwards
and
deferrals
(6,647‌)
Total
distributable
earnings
(loss)
$
7,680,227‌
T.
ROWE
PRICE
Health
Sciences
Fund
44
NOTE
6
-
RELATED
PARTY
TRANSACTIONS
The
fund
is
managed
by
T.
Rowe
Price
Associates,
Inc.
(Price
Associates),
a
wholly
owned
subsidiary
of
T.
Rowe
Price
Group,
Inc.
(Price
Group). The
investment
management
agreement
between
the
fund
and
Price
Associates
provides
for
an
annual
investment
management
fee
that
consists
of
an
individual
fund
fee
and
a
group
fee;
management
fees
are
computed
daily
and
paid
monthly.
The
investment
management
agreement
provides
for
an
individual
fund
fee
equal
to
0.35%
of
the fund’s
average
daily
net
assets.
The
group
fee
rate
is
calculated
based
on
the
combined
net
assets
of
certain
mutual
funds
sponsored
by
Price
Associates
(the
group)
applied
to
a
graduated
fee
schedule,
with
rates
ranging
from
0.48%
for
the
first
$1
billion
of
assets
to
0.260%
for
assets
in
excess
of
$845
billion.
The
fund’s
group
fee
is
determined
by
applying
the
group
fee
rate
to
the
fund’s
average
daily
net
assets.
At December
31,
2022,
the
effective
annual
group
fee
rate
was
0.29%. Effective
May
1,
2021,
Price
Associates
has
contractually
agreed,
at
least
through
April
30,
2023,
to
waive
a
portion
of
its
management
fee
so
that
an
individual
fund
fee
of 0.2975%
is
applied
to
the
fund’s
average
daily
net
assets
that
are
equal
to
or
greater
than $25 billion.
Thereafter,
this
agreement
will
automatically
renew
for
one-year
terms
unless
terminated
by
the
fund’s
Board.
Any
fees
waived
under
this
agreement
are
not
subject
to
reimbursement
to
Price
Associates
by
the
fund. No
management
fees
were
waived
under
this
arrangement
for
the
year ended
December
31,
2022. 
The
I
Class
is
subject
to
an
operating
expense
limitation
(I
Class
Limit)
pursuant
to
which
Price
Associates
is
contractually
required
to
pay
all
operating
expenses
of
the
I
Class,
excluding
management
fees;
interest;
expenses
related
to
borrowings,
taxes,
and
brokerage; non-recurring,
extraordinary expenses; and
acquired
fund
fees
and
expenses, to
the
extent
such
operating
expenses,
on
an
annualized
basis,
exceed
the
I
Class
Limit. This
agreement
will
continue
through
the
expense
limitation
date
indicated
in
the
table
below,
and
may
be
renewed,
revised,
or
revoked
only
with
approval
of
the
fund’s
Board.
The
I
Class
is
required
to
repay
Price
Associates
for
expenses
previously
paid
to
the
extent
the
class’s
net
assets
grow
or
expenses
decline
sufficiently
to
allow
repayment
without
causing
the
class’s
operating
expenses
(after
the
repayment
is
taken
into
account)
to
exceed
the
lesser
of:
(1)
the
I
Class
Limit
in
place
at
the
time
such
amounts
were
paid;
or
(2)
the
current
I
Class
Limit.
However,
no
repayment
will
be
made
more
than
three
years
after
the
date
of
a
payment
or
waiver.
T.
ROWE
PRICE
Health
Sciences
Fund
45
In
addition,
the
fund
has
entered
into
service
agreements
with
Price
Associates
and
two
wholly
owned
subsidiaries
of
Price
Associates,
each
an
affiliate
of
the
fund
(collectively,
Price).
Price
Associates
provides
certain
accounting
and
administrative
services
to
the
fund.
T.
Rowe
Price
Services,
Inc.
provides
shareholder
and
administrative
services
in
its
capacity
as
the
fund’s
transfer
and
dividend-disbursing
agent.
T.
Rowe
Price
Retirement
Plan
Services,
Inc.
provides
subaccounting
and
recordkeeping
services
for
certain
retirement
accounts
invested
in
the
Investor
Class.
For
the
year ended
December
31,
2022,
expenses
incurred
pursuant
to
these
service
agreements
were
$102,000 for
Price
Associates;
$6,898,000 for
T.
Rowe
Price
Services,
Inc.;
and
$605,000 for
T.
Rowe
Price
Retirement
Plan
Services,
Inc.
All
amounts
due
to
and
due
from
Price,
exclusive
of
investment
management
fees
payable,
are
presented
net
on
the
accompanying
Statement
of
Assets
and
Liabilities.
Additionally,
the
fund
is
one
of
several
mutual
funds
in
which
certain
college
savings
plans
managed
by
Price
Associates may
invest.
As
approved
by
the
fund’s
Board
of
Directors,
shareholder
servicing
costs
associated
with
each
college
savings
plan
are
borne
by
the
fund
in
proportion
to
the
average
daily
value
of
its
shares
owned
by
the
college
savings
plan.
Price
has
agreed
to waive/reimburse
shareholder
servicing
costs in
excess
of
0.05%
of
the
fund’s
average
daily
value
of
its
shares
owned
by
the
college
savings
plan.
Any
amounts
waived/paid
by
Price
under
this
voluntary
agreement
are
not
subject
to
repayment
by
the
fund.
Price
may
amend
or
terminate
this
voluntary
arrangement
at
any
time
without
prior
notice.
For
the
year ended
December
31,
2022,
the
fund
was
charged $112,000 for
shareholder
servicing
costs
related
to
the
college
savings
plans, of
which
$82,000
was
for
services
provided
by
Price.
All
amounts
due
to
and
due
from
Price,
exclusive
of
investment
management
fees
payable,
are
presented
net
on
the
accompanying
Statement
of
Assets
and
Liabilities. At
December
31,
2022,
approximately less
than
1%
of
the
outstanding
shares
of
the
I
Class
were
held
by
the
college
savings
plans.
The fund
may
invest
its
cash
reserves
in
certain
open-end
management
investment
companies
managed
by
Price
Associates
and
considered
affiliates
of
the
fund:
the
T.
Rowe
Price
Government
Reserve
Fund
or
the
T.
Rowe
Price
Treasury
Reserve
Fund,
organized
as
money
market
funds
(together,
the
Price
Reserve
Funds).
The
Price
Reserve
Funds
are
offered
as
short-term
investment
options
to
mutual
funds,
trusts,
and
other
I
Class
Expense
limitation/I
Class
Limit
0.05%
Expense
limitation
date
04/30/24
(Waived)/repaid
during
the
period
($000s)
$—
T.
ROWE
PRICE
Health
Sciences
Fund
46
accounts
managed
by
Price
Associates
or
its
affiliates
and
are
not
available
for
direct
purchase
by
members
of
the
public.
Cash
collateral
from
securities
lending,
if
any,
is
invested
in
the
T.
Rowe
Price
Government
Reserve Fund. The
Price
Reserve
Funds
pay
no
investment
management
fees.
As
of
December
31,
2022,
T.
Rowe
Price
Group,
Inc.,
or
its
wholly
owned
subsidiaries,
owned
140,512
shares
of
the
I
Class,
representing
less
than
1%
of
the
I
Class's
net
assets. 
The
fund may
participate
in
securities
purchase
and
sale
transactions
with
other
funds
or
accounts
advised
by
Price
Associates
(cross
trades),
in
accordance
with
procedures
adopted
by the
fund’s
Board
and
Securities
and
Exchange
Commission
rules,
which
require,
among
other
things,
that
such
purchase
and
sale
cross
trades
be
effected
at
the
independent
current
market
price
of
the
security.
During
the
year ended
December
31,
2022,
the
fund
had
no
purchases
or
sales
cross
trades
with
other
funds
or
accounts
advised
by
Price
Associates.
Price
Associates
has
voluntarily
agreed
to
reimburse
the
fund
from
its
own
resources
on
a
monthly
basis
for
the
cost
of
investment
research
embedded
in
the
cost
of
the
fund’s
securities
trades.
This
agreement
may
be
rescinded
at
any
time.
For
the
year ended
December
31,
2022,
this
reimbursement
amounted
to
$284,000,
which
is
included
in
Net
realized
gain
(loss)
on
Securities
in
the
Statement
of
Operations.
NOTE
7
-
OTHER
MATTERS
Unpredictable
events
such
as
environmental
or
natural
disasters,
war,
terrorism,
pandemics,
outbreaks
of
infectious
diseases,
and
similar
public
health
threats
may
significantly
affect
the
economy
and
the
markets
and
issuers
in
which
the fund
invests.
Certain
events
may
cause
instability
across
global
markets,
including
reduced
liquidity
and
disruptions
in
trading
markets,
while
some
events
may
affect
certain
geographic
regions,
countries,
sectors,
and
industries
more
significantly
than
others,
and
exacerbate
other
pre-existing
political,
social,
and
economic
risks.
Since
2020,
a
novel
strain
of
coronavirus
(COVID-19)
has
resulted
in
disruptions
to
global
business
activity
and
caused
significant
volatility
and
declines
in
global
financial
markets.
In
February
2022,
Russian
forces
entered
Ukraine
and
commenced
an
armed
conflict
leading
to
economic
sanctions
being
imposed
on
Russia
and
certain
of
its
citizens,
creating
impacts
on
Russian-related
stocks
and
debt
and
greater
volatility
in
global
markets.
T.
ROWE
PRICE
Health
Sciences
Fund
47
These
are
recent
examples
of
global
events
which
may
have
a
negative
impact
on
the
values
of
certain
portfolio
holdings
or
the
fund’s
overall
performance.
Management
is
actively
monitoring
the
risks
and
financial
impacts
arising
from
these
events.
T.
ROWE
PRICE
Health
Sciences
Fund
48
REPORT
OF
INDEPENDENT
REGISTERED
PUBLIC
ACCOUNTING
FIRM
To
the
Board
of
Directors
and
Shareholders
of
T.
Rowe
Price
Health
Sciences
Fund,
Inc.
Opinion
on
the
Financial
Statements
We
have
audited
the
accompanying
statement
of
assets
and
liabilities,
including
the
portfolio
of
investments,
of
T.
Rowe
Price
Health
Sciences
Fund,
Inc.
(the
"Fund")
as
of
December
31,
2022,
the
related
statement
of
operations
for
the
year
ended
December
31,
2022,
the
statement
of
changes
in
net
assets
for
each
of
the
two
years
in
the
period
ended
December
31,
2022,
including
the
related
notes,
and
the
financial
highlights
for
each
of
the
five
years
in
the
period
ended
December
31,
2022
(collectively
referred
to
as
the
“financial
statements”).
In
our
opinion,
the
financial
statements
present
fairly,
in
all
material
respects,
the
financial
position
of
the
Fund
as
of
December
31,
2022,
the
results
of
its
operations
for
the
year
then
ended,
the
changes
in
its
net
assets
for
each
of
the
two
years
in
the
period
ended
December
31,
2022
and
the
financial
highlights
for
each
of
the
five
years
in
the
period
ended
December
31,
2022
in
conformity
with
accounting
principles
generally
accepted
in
the
United
States
of
America.
Basis
for
Opinion
These
financial
statements
are
the
responsibility
of
the
Fund’s
management.
Our
responsibility
is
to
express
an
opinion
on
the
Fund’s
financial
statements
based
on
our
audits.
We
are
a
public
accounting
firm
registered
with
the
Public
Company
Accounting
Oversight
Board
(United
States)
(PCAOB)
and
are
required
to
be
independent
with
respect
to
the
Fund
in
accordance
with
the
U.S.
federal
securities
laws
and
the
applicable
rules
and
regulations
of
the
Securities
and
Exchange
Commission
and
the
PCAOB.
We
conducted
our
audits
of
these
financial
statements
in
accordance
with
the
standards
of
the
PCAOB.
Those
standards
require
that
we
plan
and
perform
the
audit
to
obtain
reasonable
assurance
about
whether
the
financial
statements
are
free
of
material
misstatement,
whether
due
to
error
or
fraud.
T.
ROWE
PRICE
Health
Sciences
Fund
49
Our
audits
included
performing
procedures
to
assess
the
risks
of
material
misstatement
of
the
financial
statements,
whether
due
to
error
or
fraud,
and
performing
procedures
that
respond
to
those
risks.
Such
procedures
included
examining,
on
a
test
basis,
evidence
regarding
the
amounts
and
disclosures
in
the
financial
statements.
Our
audits
also
included
evaluating
the
accounting
principles
used
and
significant
estimates
made
by
management,
as
well
as
evaluating
the
overall
presentation
of
the
financial
statements.
Our
procedures
included
confirmation
of
securities
owned
as
of
December
31,
2022
by
correspondence
with
the
custodians,
transfer
agent
and
brokers;
when
replies
were
not
received
from
brokers,
we
performed
other
auditing
procedures.
We
believe
that
our
audits
provide
a
reasonable
basis
for
our
opinion.   
PricewaterhouseCoopers
LLP
Baltimore,
Maryland
February
16,
2023
We
have
served
as
the
auditor
of
one
or
more
investment
companies
in
the
T.
Rowe
Price
group
of
investment
companies
since
1973.
REPORT
OF
INDEPENDENT
REGISTERED
PUBLIC
ACCOUNTING
FIRM
(continued)
T.
ROWE
PRICE
Health
Sciences
Fund
50
TAX
INFORMATION
(UNAUDITED)
FOR
THE
TAX
YEAR
ENDED 12/31/22
We
are
providing
this
information
as
required
by
the
Internal
Revenue
Code.
The
amounts
shown
may
differ
from
those
elsewhere
in
this
report
because
of
differences
between
tax
and
financial
reporting
requirements.
The
fund’s
distributions
to
shareholders
included:
$805,000 from
short-term
capital
gains 
$281,826,000 from
long-term
capital
gains,
subject
to
a
long-term
capital
gains
tax
rate
of
not
greater
than
20%
T.
ROWE
PRICE
Health
Sciences
Fund
51
INFORMATION
ON
PROXY
VOTING
POLICIES,
PROCEDURES,
AND
RECORDS
A
description
of
the
policies
and
procedures
used
by
T.
Rowe
Price
funds
to
determine
how
to
vote
proxies
relating
to
portfolio
securities
is
available
in
each
fund’s
Statement
of
Additional
Information.
You
may
request
this
document
by
calling
1-800-225-5132
or
by
accessing
the
SEC’s
website,
sec.gov.
The
description
of
our
proxy
voting
policies
and
procedures
is
also
available
on
our
corporate
website.
To
access
it,
please
visit
the
following
Web
page:
https://www.troweprice.com/corporate/us/en/utility/policies.html
Scroll
down
to
the
section
near
the
bottom
of
the
page
that
says,
“Proxy
Voting
Guidelines.”
Click
on
the
links
in
the
shaded
box.
Each
fund’s
most
recent
annual
proxy
voting
record
is
available
on
our
website
and
through
the
SEC’s
website.
To
access
it
through
T.
Rowe
Price,
visit
the
website
location
shown
above,
and
scroll
down
to
the
section
near
the
bottom
of
the
page
that
says,
“Proxy
Voting
Records.”
Click
on
the
Proxy
Voting
Records
link
in
the
shaded
box.
HOW
TO
OBTAIN
QUARTERLY
PORTFOLIO
HOLDINGS
The
fund
files
a
complete
schedule
of
portfolio
holdings
with
the
Securities
and
Exchange
Commission
(SEC)
for
the
first
and
third
quarters
of
each
fiscal
year
as
an
exhibit
to
its
reports
on
Form
N-PORT.
The
fund’s
reports
on
Form
N-PORT
are
available
electronically
on
the
SEC’s
website
(sec.gov).
In
addition,
most
T.
Rowe
Price
funds
disclose
their
first
and
third
fiscal
quarter-end
holdings
on
troweprice.com
.
T.
ROWE
PRICE
Health
Sciences
Fund
52
Liquidity
Risk
Management
Program
In
accordance
with
Rule
22e-4
(Liquidity
Rule)
under
the
Investment
Company
Act
of
1940,
as
amended,
the
fund
has
established
a
liquidity
risk
management
program
(Liquidity
Program)
reasonably
designed
to
assess
and
manage
the
fund’s
liquidity
risk,
which
generally
represents
the
risk
that
the
fund
would
not
be
able
to
meet
redemption
requests
without
significant
dilution
of
remaining
investors’
interests
in
the
fund.
The
fund’s
Board
of
Directors
(Board)
has
appointed
the
fund’s
investment
adviser,
T.
Rowe
Price
Associates,
Inc.
(Adviser),
as
the
administrator
of
the
Liquidity
Program.
As
administrator,
the
Adviser
is
responsible
for
overseeing
the
day-to-day
operations
of
the
Liquidity
Program
and,
among
other
things,
is
responsible
for
assessing,
managing,
and
reviewing
with
the
Board
at
least
annually
the
liquidity
risk
of
each
T.
Rowe
Price
fund.
The
Adviser
has
delegated
oversight
of
the
Liquidity
Program
to
a
Liquidity
Risk
Committee
(LRC),
which
is
a
cross-functional
committee
composed
of
personnel
from
multiple
departments
within
the
Adviser.
The
Liquidity Program’s principal
objectives
include
supporting
the T.
Rowe
Price
funds’ compliance
with
limits
on
investments
in
illiquid
assets
and
mitigating
the
risk
that
the
fund
will
be
unable to timely
meet
its
redemption
obligations. The
Liquidity
Program
also
includes
a
number
of
elements
that
support
the
management
and
assessment
of
liquidity
risk,
including
an
annual
assessment
of
factors
that
influence
the fund’s liquidity
and
the
periodic
classification
and
reclassification
of
a
fund’s
investments
into
categories
that
reflect
the
LRC’s
assessment
of
their
relative
liquidity
under
current
market
conditions.
Under
the
Liquidity
Program,
every
investment
held
by
the
fund
is
classified
at
least
monthly
into
one
of
four
liquidity
categories
based
on
estimations
of
the
investment’s
ability
to
be
sold
during
designated
time
frames
in
current
market
conditions
without
significantly
changing
the
investment’s
market
value.
As
required
by
the
Liquidity
Rule,
at
a
meeting
held
on
July
25,
2022,
the
Board
was
presented
with
an
annual
assessment
prepared
by
the
LRC,
on
behalf
of
the
Adviser,
that
addressed
the
operation
of
the
Liquidity
Program
and
assessed
its
adequacy
and
effectiveness
of
implementation,
including
any
material
changes
to
the
Liquidity
Program
and
the
determination
of
each
fund’s
Highly
Liquid
Investment
Minimum
(HLIM).
The
annual
assessment
included
consideration
of
the
following
factors,
as
applicable:
the
fund’s
investment
strategy
and
liquidity
of
portfolio
investments
during
normal
and
reasonably
foreseeable
stressed
conditions,
including
whether
the
investment
strategy
is
appropriate
for
an
open-end
fund,
the
extent
to
which
the
strategy
involves
a
relatively
concentrated
portfolio
or
large
positions
in
particular
issuers,
and
the
use
of
borrowings
for
investment
purposes
and
derivatives;
short-term
and
long-term
cash
flow
projections
covering
both
normal
and
reasonably
foreseeable
stressed
conditions;
and
holdings
of
cash
and
cash
equivalents,
as
well
as
available
borrowing
arrangements.
T.
ROWE
PRICE
Health
Sciences
Fund
53
For
the
fund
and
other
T.
Rowe
Price
funds,
the
annual
assessment
incorporated
a
report
related
to
a
fund’s
holdings,
shareholder
and
portfolio
concentration,
any
borrowings
during
the
period,
cash
flow
projections,
and
other
relevant
data
for
the
period
of
April
1,
2021,
through
March
31,
2022.
The
report
described
the
methodology
for
classifying
a
fund’s
investments
(including
any
derivative
transactions)
into
one
of
four
liquidity
categories,
as
well
as
the
percentage
of
a
fund’s
investments
assigned
to
each
category.
It
also
explained
the
methodology
for
establishing
a
fund’s
HLIM
and
noted
that
the
LRC
reviews
the
HLIM
assigned
to
each
fund
no
less
frequently
than
annually.
During
the
period
covered
by
the
annual
assessment,
the
LRC
has
concluded,
and
reported
to
the
Board,
that
the
Liquidity
Program
continues
to
operate
adequately
and
effectively
and
is
reasonably
designed
to
assess
and
manage
the
fund’s
liquidity
risk.
T.
ROWE
PRICE
Health
Sciences
Fund
54
ABOUT
THE
FUND'S
DIRECTORS
AND
OFFICERS
Your
fund
is
overseen
by
a
Board
of
Directors
(Board)
that
meets
regularly
to
review
a
wide
variety
of
matters
affecting
or
potentially
affecting
the
fund,
including
performance,
investment
programs,
compliance
matters,
advisory
fees
and
expenses,
service
providers,
and
business
and
regulatory
affairs.
The
Board
elects
the
fund’s
officers,
who
are
listed
in
the
final
table.
The
directors
who
are
also
employees
or
officers
of
T.
Rowe
Price
are
considered
to
be
“interested”
directors
as
defined
in
Section
2(a)(19)
of
the
1940
Act
because
of
their
relationships
with
T.
Rowe
Price
and
its
affiliates.
The
business
address
of
each
director
and
officer
is
100
East
Pratt
Street,
Baltimore,
Maryland
21202.
The
Statement
of
Additional
Information
includes
additional
information
about
the
fund
directors
and
is
available
without
charge
by
calling
a
T.
Rowe
Price
representative
at
1-800-638-5660.
INDEPENDENT
DIRECTORS
(a)
Name
(Year
of
Birth)
Year
Elected
[Number
of
T.
Rowe
Price
Portfolios
Overseen]
Principal
Occupation(s)
and
Directorships
of
Public
Companies
and
Other
Investment
Companies
During
the
Past
Five
Years
Teresa
Bryce
Bazemore
(1959)
2018
[205]
President
and
Chief
Executive
Officer,
Federal
Home
Loan
Bank
of
San
Francisco
(2021
to
present);
President,
Radian
Guaranty
(2008
to
2017);
Chief
Executive
Officer,
Bazemore
Consulting
LLC
(2018
to
2021);
Director,
Chimera
Investment
Corporation
(2017
to
2021);
Director,
First
Industrial
Realty
Trust
(2020
to
present);
Director,
Federal
Home
Loan
Bank
of
Pittsburgh
(2017
to
2019)
Ronald
J.
Daniels
(b)
(1959)
2018
[0]
President,
The
Johns
Hopkins
University
and
Professor,
Political
Science
Department,
The
Johns
Hopkins
University
(2009
to
present);
Director,
Lyndhurst
Holdings
(2015
to
present);
Director,
BridgeBio
Pharma,
Inc.
(2020
to
present)
Bruce
W.
Duncan
(1951)
2013
[205]
President,
Chief
Executive
Officer,
and
Director,
CyrusOne,
Inc.
(2020
to
2021);
Chief
Executive
Officer
and
Director
(2009
to
2016),
Chair
of
the
Board
(2016
to
2020),
and
President
(2009
to
2016),
First
Industrial
Realty
Trust,
owner
and
operator
of
industrial
properties;
Chair
of
the
Board
(2005
to
2016)
and
Director
(1999
to
2016),
Starwood
Hotels
&
Resorts,
a
hotel
and
leisure
company;
Member,
Investment
Company
Institute
Board
of
Governors
(2017
to
2019);
Member,
Independent
Directors
Council
Governing
Board
(2017
to
2019);
Senior
Advisor,
KKR
(2018
to
present);
Director,
Boston
Properties
(2016
to
present);
Director,
Marriott
International,
Inc.
(2016
to
2020)
Robert
J.
Gerrard,
Jr.
(1952)
2012
[205]
Advisory
Board
Member,
Pipeline
Crisis/Winning
Strategies,
a
collaborative
working
to
improve
opportunities
for
young
African
Americans
(1997
to
2016);
Chair
of
the
Board,
all
funds
(July
2018
to
present)
T.
ROWE
PRICE
Health
Sciences
Fund
55
INTERESTED  DIRECTORS
(a)
Name
(Year
of
Birth)
Year
Elected
[Number
of
T.
Rowe
Price
Portfolios
Overseen]
Principal
Occupation(s)
and
Directorships
of
Public
Companies
and
Other
Investment
Companies
During
the
Past
Five
Years
Paul
F.
McBride
(1956)
2013
[205]
Advisory
Board
Member,
Vizzia
Technologies
(2015
to
present);
Board
Member,
Dunbar
Armored
(2012
to
2018)
Kellye
L.
Walker
(c)
(1966)
2021
[205]
Executive
Vice
President
and
Chief
Legal
Officer,
Eastman
Chemical
Company
(April
2020
to
present);
Executive
Vice
President
and
Chief
Legal
Officer,
Huntington
Ingalls
Industries,
Inc.
(January
2015
to
March
2020);
Director,
Lincoln
Electric
Company
(October
2020
to
present)
(a)
All
information
about
the
independent
directors
was
current
as
of
December
31,
2021,
unless
otherwise
indicated,
except
for
the
number
of
portfolios
overseen,
which
is
current
as
of
the
date
of
this
report.
(b)
Effective
April
27,
2022,
Mr.
Daniels
resigned
from
his
role
as
an
independent
director
of
the
Price
Funds.
(c)
Effective
November
8,
2021,
Ms.
Walker
was
appointed
as
an
independent
director
of
the
Price
Funds.
Name
(Year
of
Birth)
Year
Elected
[Number
of
T.
Rowe
Price
Portfolios
Overseen]
Principal
Occupation(s)
and
Directorships
of
Public
Companies
and
Other
Investment
Companies
During
the
Past
Five
Years
David
Oestreicher
(1967)
2018
[205]
Director,
Vice
President,
and
Secretary,
T.
Rowe
Price,
T.
Rowe
Price
Investment
Services,
Inc.,
T.
Rowe
Price
Retirement
Plan
Services,
Inc.,
and
T.
Rowe
Price
Services,
Inc.;
Director
and
Secretary,
T.
Rowe
Price
Investment
Management,
Inc.
(Price
Investment
Management);
Vice
President
and
Secretary,
T.
Rowe
Price
International
(Price
International);
Vice
President,
T.
Rowe
Price
Hong
Kong
(Price
Hong
Kong),
T. Rowe
Price
Japan
(Price
Japan),
and
T.
Rowe
Price
Singapore
(Price
Singapore);
General
Counsel,
Vice
President,
and
Secretary,
T.
Rowe
Price
Group,
Inc.;
Chair
of
the
Board,
Chief
Executive
Officer,
President,
and
Secretary,
T.
Rowe
Price
Trust
Company;
Principal
Executive
Officer
and
Executive
Vice
President,
all
funds
Robert
W.
Sharps,
CFA,
CPA
(b)
(1971)
2017
[0]
Director
and
Vice
President,
T.
Rowe
Price;
Director,
Price
Investment
Management;
Chief
Executive
Officer
and
President,
T.
Rowe
Price
Group,
Inc.;
Vice
President,
T.
Rowe
Price
Trust
Company
INDEPENDENT
DIRECTORS
(a)
(CONTINUED)
T.
ROWE
PRICE
Health
Sciences
Fund
56
OFFICERS
Name
(Year
of
Birth)
Year
Elected
[Number
of
T.
Rowe
Price
Portfolios
Overseen]
Principal
Occupation(s)
and
Directorships
of
Public
Companies
and
Other
Investment
Companies
During
the
Past
Five
Years
Eric
L.
Veiel,
CFA
(1972)
2022
[205]
Director
and
Vice
President,
T.
Rowe
Price;
Vice
President,
T.
Rowe
Price
Group,
Inc.,
and
T.
Rowe
Price
Trust
Company
(a)
All
information
about
the
interested
directors
was
current
as
of
January
1,
2022,
unless
otherwise
indicated,
except
for
the
number
of
portfolios
overseen,
which
is
current
as
of
the
date
of
this
report.
(b)
Effective
February
3,
2022,
Mr.
Sharps
resigned
from
his
role
as
an
interested
director
of
the
Price
Funds.
Name
(Year
of
Birth)
Position
Held
With
Health
Sciences
Fund
Principal
Occupation(s) 
Zachary
Baca 
(1990)
Vice
President
Vice
President,
T.
Rowe
Price;
formerly,
Associate,
Rock
Springs
Capital
(to
2020)
Ziad
Bakri,
M.D.,
CFA
(1980)
President
Vice
President,
T.
Rowe
Price
and
T.
Rowe
Price
Group,
Inc.
Armando
(Dino)
Capasso
(1974)
Chief
Compliance
Officer
Chief
Compliance
Officer
and
Vice
President,
T.
Rowe
Price
and
Price
Investment
Management;
Vice
President,
T.
Rowe
Price
Group,
Inc.;
formerly,
Chief
Compliance
Officer,
PGIM
Investments
LLC
and
AST
Investment
Services,
Inc.
(ASTIS)
(to
2022);
Chief
Compliance
Officer,
PGIM
Retail
Funds
complex
and
Prudential
Insurance
Funds
(to
2022);
Vice
President
and
Deputy
Chief
Compliance
Officer,
PGIM
Investments
LLC
and
ASTIS
(to
2019);
Senior
Vice
President
and
Senior
Counsel,
Pacific
Investment
Management
Company
LLC
(to
2017) 
Anne
Daub
(1973)
Vice
President
Vice
President,
T.
Rowe
Price
and
T.
Rowe
Price
Group,
Inc.;
formerly,
Senior
Analyst,
Soros
Fund
Management
LLC
(to
2018)
Alan
S.
Dupski,
CPA
(1982)
Principal
Financial
Officer,
Vice
President,
and
Treasurer
Vice
President,
Price
Investment
Management,
T.
Rowe
Price,
T.
Rowe
Price
Group,
Inc.,
and
T.
Rowe
Price
Trust
Company
Unless
otherwise
noted,
officers
have
been
employees
of
T.
Rowe
Price
or
Price
International
for
at
least
5
years.
INTERESTED  DIRECTORS
(a)
(CONTINUED)
T.
ROWE
PRICE
Health
Sciences
Fund
57
Name
(Year
of
Birth)
Position
Held
With
Health
Sciences
Fund
Principal
Occupation(s) 
Gary
J.
Greb
(1961)
Vice
President
Vice
President,
Price
Investment
Management,
T.
Rowe
Price,
Price
International,
and
T.
Rowe
Price
Trust
Company
John
Hall
(1977)
Vice
President
Vice
President,
T.
Rowe
Price
and
T.
Rowe
Price
Group,
Inc.
Cheryl
Hampton,
CPA
(1969)
Vice
President
Vice
President,
T.
Rowe
Price;
formerly,
Tax
Director,
Invesco
Ltd.
(to
2021);
Vice
President,
Oppenheimer
Funds,
Inc.
(to
2019)
Amanda
Ho 
(1993)
Vice
President
Employee,
T.
Rowe
Price;
summer
intern,
T.
Rowe
Price
(to
2020);
formerly,
Revenue
Strategy,
Senior
Analyst,
Snap,
Inc.
(to
2019)
Kate
Hobbs
(1982)
Vice
President
Vice
President,
T.
Rowe
Price
and
T.
Rowe
Price
Group,
Inc.;
formerly,
Portfolio
Manager,
Millennium
Partners
(to
2020);
Senior
Analyst,
Citadel
LLC,
Aptigon
Capital
(to
2018)
Jeffrey
Holford,
Ph.D.,
ACA
(1972)
Vice
President
Vice
President,
T.
Rowe
Price
and
T.
Rowe
Price
Group,
Inc.;
formerly,
Managing
Director,
Jeffries
Financial
Group
(to
2018)
Rachel
D.
Jonas
(1983)
Vice
President
Vice
President,
T.
Rowe
Price
and
T.
Rowe
Price
Group,
Inc.
Jill
Jortner
(1977)
Vice
President
Employee,
T.
Rowe
Price;
formerly,
Research
Analyst,
Iridian
Asset
Management
(to
2022)
Benjamin
Kersse,
CPA
(1989)
Vice
President
Vice
President,
T.
Rowe
Price
Paul
J.
Krug,
CPA
(1964)
Vice
President
Vice
President,
T.
Rowe
Price,
T.
Rowe
Price
Group,
Inc.,
and
T.
Rowe
Price
Trust
Company
Fran
M.
Pollack-Matz
(1961)
Vice
President
and
Secretary 
Vice
President,
T.
Rowe
Price,
T.
Rowe
Price
Group,
Inc.,
T.
Rowe
Price
Investment
Services,
Inc.,
and
T.
Rowe
Price
Services,
Inc.
Shannon
H.
Rauser
(1987)
Assistant
Secretary 
Assistant
Vice
President,
T.
Rowe
Price
Taymour
R.
Tamaddon,
CFA
(1976)
Vice
President
Vice
President,
T.
Rowe
Price,
T.
Rowe
Price
Group,
Inc.,
and
T.
Rowe
Price
Trust
Company
Unless
otherwise
noted,
officers
have
been
employees
of
T.
Rowe
Price
or
Price
International
for
at
least
5
years.
OFFICERS
(CONTINUED)
T.
ROWE
PRICE
Health
Sciences
Fund
58
Name
(Year
of
Birth)
Position
Held
With
Health
Sciences
Fund
Principal
Occupation(s) 
Megan
Warren
(1968)
Vice
President
OFAC
Sanctions
Compliance
Officer
and
Vice
President,
Price
Investment
Management;
Vice
President,
T.
Rowe
Price,
T.
Rowe
Price
Group,
Inc.,
T.
Rowe
Price
Retirement
Plan
Services,
Inc.,
T.
Rowe
Price
Services,
Inc.,
and
T.
Rowe
Price
Trust
Company
Unless
otherwise
noted,
officers
have
been
employees
of
T.
Rowe
Price
or
Price
International
for
at
least
5
years.
OFFICERS
(CONTINUED)
T.
Rowe
Price
Investment
Services,
Inc.
|
100
East
Pratt
Street
|
Baltimore,
MD
21202-1009
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Advisers
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Brokerage
services
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Price
Investment
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Company,
member
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202302-2582632
F114-050
2/23


Item 1. (b) Notice pursuant to Rule 30e-3.

Not applicable.

Item 2.  Code of Ethics.

The registrant has adopted a code of ethics, as defined in Item 2 of Form N-CSR, applicable to its principal executive officer, principal financial officer, principal accounting officer or controller, or persons performing similar functions. A copy of this code of ethics is filed as an exhibit to this Form N-CSR. No substantive amendments were approved or waivers were granted to this code of ethics during the period covered by this report.

Item 3.  Audit Committee Financial Expert.

The registrant’s Board of Directors has determined that Ms. Teresa Bryce Bazemore qualifies as an audit committee financial expert, as defined in Item 3 of Form N-CSR. Ms. Bazemore is considered independent for purposes of Item 3 of Form N-CSR.

Item 4.  Principal Accountant Fees and Services.

(a) – (d)  Aggregate fees billed for the last two fiscal years for professional services rendered to, or on behalf of, the registrant by the registrant’s principal accountant were as follows:

 

        

2022

           

2021

 
 

Audit Fees

   $ 41,909                        $ 40,759  
 

Audit-Related Fees

     -           -  
 

Tax Fees

     -           5,742  

        

 

All Other Fees

     -           -  

Audit fees include amounts related to the audit of the registrant’s annual financial statements and services normally provided by the accountant in connection with statutory and regulatory filings. Audit-related fees include amounts reasonably related to the performance of the audit of the registrant’s financial statements and specifically include the issuance of a report on internal controls and, if applicable, agreed-upon procedures related to fund acquisitions. Tax fees include amounts related to services for tax compliance, tax planning, and tax advice. The nature of these services specifically includes the review of distribution calculations and the preparation of Federal, state, and excise tax returns. All other fees include the registrant’s pro-rata share of amounts for agreed-upon procedures in conjunction with service contract approvals by the registrant’s Board of Directors/Trustees.

(e)(1)  The registrant’s audit committee has adopted a policy whereby audit and non-audit services performed by the registrant’s principal accountant for the registrant, its investment adviser, and any entity controlling, controlled by, or under common control with the investment adviser that provides ongoing services to the registrant require pre-approval in advance at regularly scheduled audit committee meetings. If such a service is required between regularly scheduled audit committee meetings, pre-approval may be authorized by one audit committee member with ratification at the next scheduled audit committee meeting. Waiver of pre-approval for audit or non-audit services requiring fees of a de minimis amount is not permitted.

(2)  No services included in (b) – (d) above were approved pursuant to paragraph (c)(7)(i)(C) of Rule 2-01 of Regulation S-X.

 


(f)  Less than 50 percent of the hours expended on the principal accountant’s engagement to audit the registrant’s financial statements for the most recent fiscal year were attributed to work performed by persons other than the principal accountant’s full-time, permanent employees.

(g)  The aggregate fees billed for the most recent fiscal year and the preceding fiscal year by the registrant’s principal accountant for non-audit services rendered to the registrant, its investment adviser, and any entity controlling, controlled by, or under common control with the investment adviser that provides ongoing services to the registrant were $2,037,000 and $3,732,000, respectively.

(h)  All non-audit services rendered in (g) above were pre-approved by the registrant’s audit committee. Accordingly, these services were considered by the registrant’s audit committee in maintaining the principal accountant’s independence.

Item 5.  Audit Committee of Listed Registrants.

Not applicable.

Item 6. Investments.

(a)  Not applicable. The complete schedule of investments is included in Item 1 of this Form N-CSR.

(b)  Not applicable.

Item 7.  Disclosure of Proxy Voting Policies and Procedures for Closed-End Management Investment Companies.

Not applicable.

Item 8.  Portfolio Managers of Closed-End Management Investment Companies.

Not applicable.

Item 9.  Purchases of Equity Securities by Closed-End Management Investment Company and Affiliated Purchasers.

Not applicable.

Item 10.  Submission of Matters to a Vote of Security Holders.

There has been no change to the procedures by which shareholders may recommend nominees to the registrant’s board of directors.

Item 11.  Controls and Procedures.

(a)  The registrant’s principal executive officer and principal financial officer have evaluated the registrant’s disclosure controls and procedures within 90 days of this filing and have concluded that the registrant’s disclosure controls and procedures were effective, as of that date, in ensuring that information required to be disclosed by the registrant in this Form N-CSR was recorded, processed, summarized, and reported timely.

 


(b)  The registrant’s principal executive officer and principal financial officer are aware of no change in the registrant’s internal control over financial reporting that occurred during the period covered by this report that has materially affected, or is reasonably likely to materially affect, the registrant’s internal control over financial reporting.

Item 12. Disclosure of Securities Lending Activities for Closed-End Management Investment Companies.

Not applicable.

Item 13.   Exhibits.

(a)(1) The registrant’s code of ethics pursuant to Item 2 of Form N-CSR is attached.

    (2) Separate certifications by the registrant’s principal executive officer and principal financial officer, pursuant to Section 302 of the Sarbanes-Oxley Act of 2002 and required by Rule 30a-2(a) under the Investment Company Act of 1940, are attached.

    (3) Written solicitation to repurchase securities issued by closed-end companies: not applicable.

(b) A certification by the registrant’s principal executive officer and principal financial officer, pursuant to Section  906 of the Sarbanes-Oxley Act of 2002 and required by Rule 30a-2(b) under the Investment Company Act of 1940, is attached.

 


SIGNATURES

Pursuant to the requirements of the Securities Exchange Act of 1934 and the Investment Company Act of 1940, the registrant has duly caused this report to be signed on its behalf by the undersigned, thereunto duly authorized.

T. Rowe Price Health Sciences Fund, Inc.

 

By  

/s/ David Oestreicher

  David Oestreicher
  Principal Executive Officer
Date       February 16, 2023

Pursuant to the requirements of the Securities Exchange Act of 1934 and the Investment Company Act of 1940, this report has been signed below by the following persons on behalf of the registrant and in the capacities and on the dates indicated.

 

By  

/s/ David Oestreicher

  David Oestreicher
  Principal Executive Officer
Date       February 16, 2023

 

By  

/s/ Alan S. Dupski

  Alan S. Dupski
  Principal Financial Officer
Date       February 16, 2023
 
EX-99.CERT 2 d403076dex99cert.htm 302 CERTIFICATIONS 302 CERTIFICATIONS

Item 13. (a)(2)

CERTIFICATIONS

I, David Oestreicher, certify that:

 

1.

I have reviewed this report on Form N-CSR of T. Rowe Price Health Sciences Fund;

 

2.

Based on my knowledge, this report does not contain any untrue statement of a material fact or omit to state a material fact necessary to make the statements made, in light of the circumstances under which such statements were made, not misleading with respect to the period covered by this report;

 

3.

Based on my knowledge, the financial statements, and other financial information included in this report, fairly present in all material respects the financial condition, results of operations, changes in net assets, and cash flows (if the financial statements are required to include a statement of cash flows) of the registrant as of, and for, the periods presented in this report;

 

4.

The registrant’s other certifying officer(s) and I are responsible for establishing and maintaining disclosure controls and procedures (as defined in rule 30a-3(c) under the Investment Company Act of 1940) and internal control over financial reporting (as defined in Rule 30a-3(d) under the Investment Company Act of 1940) for the registrant and have:

 

  (a)

Designed such disclosure controls and procedures, or caused such disclosure controls and procedures to be designed under our supervision, to ensure that material information relating to the registrant, including its consolidated subsidiaries, is made known to us by others within those entities, particularly during the period in which this report is being prepared;

 

  (b)

Designed such internal control over financial reporting, or caused such internal control over financial reporting to be designed under our supervision, to provide reasonable assurance regarding the reliability of financial reporting and the preparation of financial statements for external purposes in accordance with generally accepted accounting principles;

 

  (c)

Evaluated the effectiveness of the registrant’s disclosure controls and procedures and presented in this report our conclusions about the effectiveness of the disclosure controls and procedures, as of a date within 90 days prior to the filing date of this report based on such evaluation; and

 

  (d)

Disclosed in this report any change in the registrant’s internal control over financial reporting that occurred during the period covered by this report that has materially affected, or is reasonably likely to materially affect, the registrant’s internal control over financial reporting; and

 

5.

The registrant’s other certifying officer(s) and I have disclosed to the registrant’s auditors and the audit committee of the registrant’s board of directors (or persons performing the equivalent functions):

 

  (a)

All significant deficiencies and material weaknesses in the design or operation of internal control over financial reporting which are reasonably likely to adversely affect the registrant’s ability to record, process, summarize, and report financial information; and

 

  (b)

Any fraud, whether or not material, that involves management or other employees who have a significant role in the registrant’s internal control over financial reporting.

 

Date: February 16, 2023

   

                                                     

 

/s/ David Oestreicher

     

David Oestreicher

     

Principal Executive Officer


CERTIFICATIONS

I, Alan S. Dupski, certify that:

 

1.

I have reviewed this report on Form N-CSR of T. Rowe Price Health Sciences Fund;

 

2.

Based on my knowledge, this report does not contain any untrue statement of a material fact or omit to state a material fact necessary to make the statements made, in light of the circumstances under which such statements were made, not misleading with respect to the period covered by this report;

 

3.

Based on my knowledge, the financial statements, and other financial information included in this report, fairly present in all material respects the financial condition, results of operations, changes in net assets, and cash flows (if the financial statements are required to include a statement of cash flows) of the registrant as of, and for, the periods presented in this report;

 

4.

The registrant’s other certifying officer(s) and I are responsible for establishing and maintaining disclosure controls and procedures (as defined in rule 30a-3(c) under the Investment Company Act of 1940) and internal control over financial reporting (as defined in Rule 30a-3(d) under the Investment Company Act of 1940) for the registrant and have:

 

  (a)

Designed such disclosure controls and procedures, or caused such disclosure controls and procedures to be designed under our supervision, to ensure that material information relating to the registrant, including its consolidated subsidiaries, is made known to us by others within those entities, particularly during the period in which this report is being prepared;

 

  (b)

Designed such internal control over financial reporting, or caused such internal control over financial reporting to be designed under our supervision, to provide reasonable assurance regarding the reliability of financial reporting and the preparation of financial statements for external purposes in accordance with generally accepted accounting principles;

 

  (c)

Evaluated the effectiveness of the registrant’s disclosure controls and procedures and presented in this report our conclusions about the effectiveness of the disclosure controls and procedures, as of a date within 90 days prior to the filing date of this report based on such evaluation; and

 

  (d)

Disclosed in this report any change in the registrant’s internal control over financial reporting that occurred during the period covered by this report that has materially affected, or is reasonably likely to materially affect, the registrant’s internal control over financial reporting; and

 

5.

The registrant’s other certifying officer(s) and I have disclosed to the registrant’s auditors and the audit committee of the registrant’s board of directors (or persons performing the equivalent functions):

 

  (a)

All significant deficiencies and material weaknesses in the design or operation of internal control over financial reporting which are reasonably likely to adversely affect the registrant’s ability to record, process, summarize, and report financial information; and

 

  (b)

Any fraud, whether or not material, that involves management or other employees who have a significant role in the registrant’s internal control over financial reporting.

 

Date: February 16, 2023

   

                                                     

 

/s/ Alan S. Dupski

     

Alan S. Dupski

     

Principal Financial Officer

EX-99.906CE 3 d403076dex99906ce.htm 906 CERTIFICATIONS 906 CERTIFICATIONS

Item 13. (b)

CERTIFICATION UNDER SECTION 906 OF SARBANES-OXLEY ACT OF 2002

Name of Issuer: T. Rowe Price Health Sciences Fund

In connection with the Report on Form N-CSR for the above named Issuer, the undersigned hereby certifies, to the best of his knowledge, that:

 

  1.

The Report fully complies with the requirements of Section 13(a) or 15(d) of the Securities Exchange Act of 1934;

 

  2.

The information contained in the Report fairly presents, in all material respects, the financial condition and results of operations of the Issuer.

 

Date: February 16, 2023      

/s/ David Oestreicher

      David Oestreicher
      Principal Executive Officer
Date: February 16, 2023      

/s/ Alan S. Dupski

      Alan S. Dupski
      Principal Financial Officer
EX-99.CODE ETH 4 d403076dex99codeeth.htm CODE OF ETHICS CODE OF ETHICS

CODE OF ETHICS FOR PRINCIPAL EXECUTIVE AND SENIOR FINANCIAL

OFFICERS OF THE T. ROWE PRICE MUTUAL FUNDS AND EXCHANGE-

TRADED FUNDS

UNDER THE SARBANES-OXLEY ACT OF 2002

I.  General Statement. This Code of Ethics for the T. Rowe Price Mutual Funds and Exchange-Traded Funds (the “Price ETFs” and, together with the Mutual Funds, the “Price Funds”) has been designed to bring the Price Funds into compliance with the applicable requirements of the Sarbanes-Oxley Act of 2002 (the “Act”) and rules promulgated by the Securities and Exchange Commission thereunder (“Regulations”). This Price Funds’ Code of Ethics (the “S-O Code”) applies solely to the Principal Executive Officer, Principal Financial Officer, Principal Accounting Officer or Controller of, or persons performing similar functions for, a Price Fund (whether such persons are employed by a Price Fund or third party) (“Covered Officers”). The “Price Funds” shall include each mutual fund and ETF that is managed, sponsored and distributed by affiliates of T. Rowe Price Group, Inc. (“Group”). The investment managers to the Price Funds will be referred to as the “Price Fund Advisers.” A list of Covered Officers is attached as Exhibit A.

The Price Fund Advisers have, along with their parent, T. Rowe Price Group, Inc. (“Group”) also maintained a comprehensive Code of Ethics and Conduct (the “Group Code”) since 1972, which applies to all officers, directors and employees of the Price Funds, Group and its affiliates.

As mandated by the Act, Group has adopted a Code (the “Group S-O Code”), similar to the Price Funds S-O Code, which applies solely to its principal executive and senior financial officers. The Group S-O Code and the Price Funds S-O Code will be referred to collectively as the “S-O Codes”.

The Price Funds S-O Code has been adopted by the Price Funds in accordance with the Act and Regulations thereunder and will be administered in conformity with the disclosure requirements of Item 2 of Form N-CSR. The S-O Codes are attachments to the Group Code. In many respects the S-O Codes are supplementary to the Group Code, but the Group Code is administered separately from the S-O Codes, as the S-O Codes are from each other.

II.  Purpose of the Price Funds S-O Code. The purpose of the Price Funds S-O Code, as mandated by the Act and the Regulations, is to establish standards that are reasonably designed to deter wrongdoing and to promote:

Ethical Conduct. Honest and ethical conduct, including the ethical handling of actual or apparent conflicts of interest between personal and professional relationships.

Disclosure. Full, fair, accurate, timely and understandable disclosure in reports and documents that the Price Funds file with, or submit to, the SEC and in other public communications made by the Price Funds.

Compliance. Compliance with applicable governmental laws, rules and regulations.

Reporting of Violations. The prompt internal reporting of violations of the Price Funds S-O Code to an appropriate person or persons identified in the Price Funds S-O Code.

Accountability. Accountability for adherence to the Price Funds S-O Code.

 

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III.  Covered Officers Should Handle Ethically Actual and Apparent Conflicts of Interest.

Overview. Each Covered Officer owes a duty to the Price Funds to adhere to a high standard of honesty and business ethics and should be sensitive to situations that may give rise to actual as well as apparent conflicts of interest.

A “conflict of interest” occurs when a Covered Officer’s private interest interferes with the interests of, or his or her service to, the Price Funds. For example, a conflict of interest would arise if a Covered Officer, or a member of his or her family, receives improper personal benefits as a result of his or her position with a Price Fund.

Certain conflicts of interest covered by the Price Funds S-O Code arise out of the relationships between Covered Officers and the Price Funds and may already be subject to provisions regulating conflicts of interest in the Investment Company Act of 1940 (“Investment Company Act”), the Investment Advisers Act of 1940 (“Investment Advisers Act”) and the Group Code. For example, Covered Officers may not individually engage in certain transactions (such as the purchase or sale of securities or other property) with a Price Fund because of their status as “affiliated persons” of a Price Fund. The compliance programs and procedures of the Price Funds and Price Fund Advisers are designed to prevent, or identify and correct, violations of these provisions.

Although typically not presenting an opportunity for improper personal benefit, conflicts arise from, or as a result of, the contractual relationship between a Price Fund and its Price Fund Adviser (and its affiliates) of which the Covered Officers may also be officers or employees. As a result, the Price Funds S-O Code recognizes that the Covered Officers will, in the normal course of their duties (whether formally for the Price Funds or for the Price Fund Advisers, or for both), be involved in establishing policies and implementing decisions which will have different effects on these entities. The participation of the Covered Officers in such activities is inherent in the contractual relationship between each Price Fund and its respective Price Fund Adviser. Such participation is also consistent with the performance by the Covered Officers of their duties as officers of the Price Funds and, if consistent with the provisions of the Investment Company Act and the Investment Advisers Act, it will be deemed to have been handled ethically.

Other conflicts of interest are covered by the Price Funds and Price ETFs S-O Code, even if these conflicts of interest are not addressed by or subject to provisions in the Investment Company Act and the Investment Advisers Act.

Whenever a Covered Officer is confronted with a conflict of interest situation where he or she is uncertain as to the appropriate action to be taken, he or she should discuss the matter with the Chairperson of Group’s Ethics Committee or another member of the Committee.

Handling of Specific Types of Conflicts. Each Covered Officer (and close family members) must not:

Entertainment. Accept entertainment from any company with which any Price Fund or any Price Fund Adviser has current or prospective business dealings including portfolio companies, unless such entertainment is in full compliance with the policy on entertainment as set forth in the Group Code.

 

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Gifts. Accept any gifts, except as permitted by the Group Code.

Improper Personal Influence. Use his or her personal influence or personal relationships improperly to influence investment decisions, brokerage allocations or financial reporting by the Price Funds to the detriment of any one or more of the Price Funds.

Taking Action at the Expense of a Price Fund. Cause a Price Fund to take action, or fail to take action, for the personal benefit of the Covered Officer rather than for the benefit of one or more of the Price Funds.

Misuse of Price Funds’ Transaction Information. Use knowledge of portfolio transactions made or contemplated for a Price Fund or any other clients of the Price Fund Advisers to trade personally or cause others to trade in order to take advantage of or avoid the market impact of such portfolio transactions; and in connection with Price ETFs that do not disclose portfolio holdings daily, use knowledge of pending changes to an ETF’s proxy portfolio holdings for such purposes.

Outside Business Activities. Engage in any outside business activity that detracts from a Covered Officer’s ability to devote appropriate time and attention to his or her responsibilities to a Price Fund.

Service Providers. Excluding Group and its affiliates, have any ownership interest in, or any consulting or employment relationship with, any of the Price Funds’ service providers, except that an ownership interest in public companies is permitted

Receipt of Payments. Have a direct or indirect financial interest in commissions, transaction charges, spreads or other payments paid by a Price Fund for effecting portfolio transactions or for selling or redeeming shares other than an interest (such as compensation or equity ownership) arising from the Covered Officer’s employment by Group or any of its affiliates.

Service as a Director or Trustee. Serve as a director, trustee or officer of any public or private company or a non-profit organization that issues securities eligible for purchase by any of the Price Funds, unless approval is obtained as required by the Group Code.

IV.  Covered Officers’ Specific Obligations and Accountabilities.

A.  Disclosure Requirements and Controls. Each Covered Officer must familiarize himself or herself with the disclosure requirements (Form N-lA registration statement, proxy (Schedule 14A), shareholder reports, Forms N-CEN, N-CSR, etc.) applicable to the Price Funds and the disclosure controls and procedures of the Price Fund and the Price Fund Advisers.

B.  Compliance with Applicable Law. It is the responsibility of each Covered Officer to promote compliance with all laws, rules and regulations applicable to the Price Funds and the Price Fund Advisers. Each Covered Officer should, to the extent appropriate within his or her area of responsibility, consult with other officers and employees of the Price Funds and the Price Fund Advisers and take other appropriate steps with the goal of promoting full, fair, accurate, timely and understandable disclosure in the reports and documents the Price Funds file with, or submit to, the SEC, and in other public

 

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communications made by the Price Funds.

C.   Fair Disclosure. Each Covered Officer must not knowingly misrepresent, or cause others to misrepresent, facts about a Price Fund to others, whether within or outside the Price organization, including to the Price Fund’s directors and auditors, and to governmental regulators and self-regulatory organizations.

D.  Initial and Annual Affirmations. Each Covered Officer must:

1.  Upon adoption of the Price Funds S-O Code (or thereafter, as applicable, upon becoming a Covered Officer), affirm in writing that he or she has received, read, and understands the Price Funds S-O Code.

2.  Annually affirm that he or she has complied with the requirements of the Price Funds S-O Code.

E.  Reporting of Material Violations of the Price Funds S-O Code. If a Covered Officer becomes aware of any material violation of the Price Funds S-O Code or laws and governmental rules and regulations applicable to the operations of the Price Funds, he or she must promptly report the violation (“Report”) to the Chief Compliance Officer of the Price Funds (“CCO”). Failure to report a material violation will be considered itself a violation of the Price Funds S-O Code. The CCO is identified in the attached Exhibit B.

It is the Price Funds’ policy that no retaliation or other adverse action will be taken against any Covered Officer or other employee of a Price Fund, a Price Fund Adviser or their affiliates based upon any lawful actions of the Covered Officer or employee with respect to a Report made in good faith.

F.  Annual Disclosures. Each Covered Officer must report, at least annually, all affiliations or other relationships as called for in the “Annual Compliance Certification” for T. Rowe Price Group.

V.  Administration of the Price Funds S-O Code. The Ethics Committee is responsible for administering the Price Funds S-O Code and applying its provisions to specific situations in which questions are presented.

A.  Waivers and Interpretations. The Chairperson of the Ethics Committee has the authority to interpret the Price Funds S-O Code in any particular situation and to grant waivers where justified, subject to the approval of the Joint Audit Committee of the Price Funds. All material interpretations concerning Covered Officers will be reported to the Joint Audit Committee of the Price Funds at its next meeting. Waivers, including implicit waivers, to Covered Officers will be publicly disclosed as required in the Instructions to N-CSR. Pursuant to the definition in the Regulations, an implicit waiver means a Price Fund’s failure to take action within a reasonable period of time regarding a material departure from a provision of the Price Funds S-O Code that has been made known to an “executive officer” (as defined in Rule 3b-7 under the Securities Exchange Act of 1934) of a Price Fund. An executive officer of a Price Fund includes its president and any vice-president in charge of a principal business unit, division or function.

B.  Violations/Investigations. The following procedures will be followed in

 

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investigating and enforcing the Price Funds S-O Code:

1.  The CCO will take or cause to be taken appropriate action to investigate any potential or actual violation reported to him or her.

2.  The CCO, after consultation if deemed appropriate with Outside Counsel to the Price Funds, will make a recommendation to the appropriate Price Funds Board regarding the action to be taken with regard to each material violation. Such action could include any of the following: a letter of censure or suspension, a fine, a suspension of trading privileges or termination of officership or employment. In addition, the violator may be required to surrender any profit realized (or loss avoided) from any activity that is in violation of the Price Funds S-O Code.

3.  Investigations of Whistleblower complaints related to Price Funds will be handled in accordance with the T. Rowe Price Global Whistleblower Policy.

VI.  Amendments to the Price Funds S-O Code. Except as to the contents of Exhibit A and Exhibit B, the Price Funds S-O Code may not be materially amended except in written form, which is specifically approved or ratified by a majority vote of each Price Fund Board, including a majority of the independent directors on each Board.

VII.  Confidentiality. All reports and records prepared or maintained pursuant to the Price Funds S-O Code will be considered confidential and shall be maintained and protected accordingly. Except as otherwise required by law, the Price Funds S-O Code or as necessary in connection with regulations under the Price Funds S-O Code, such matters shall not be disclosed to anyone other than the directors of the appropriate Price Fund Board, Outside Counsel to the Price Funds, members of the Ethics Committee and the CCO and authorized persons on his or her staff.

Adoption Date:    10/22/03

Last Revised:       05/11/2022 (Exhibit B revised)

 

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Exhibit A

Persons Covered by the Price Funds and

Price ETFs S-O Code of Ethics

David Oestreicher, Executive Vice President and Principal Executive Officer

Alan S. Dupski, Treasurer and Principal Financial Officer

Exhibit B

Dino Capasso, Chief Compliance Officer

 

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