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      <invstOrSec>
        <name>ARGENX SE - ADR</name>
        <lei>7245009C5FZE6G9ODQ71</lei>
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        <assetCat>EC</assetCat>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>ARSENAL BIOSCIENCES SER C CVT PFD PP</name>
        <lei>N/A</lei>
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        <fairValLevel>3</fairValLevel>
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      <invstOrSec>
        <name>ASCENDIS PHARMA A/S - ADR</name>
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        <fairValLevel>1</fairValLevel>
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        <name>ASTRAZENECA PLC-SPONS ADR</name>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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        <name>AURA BIOSCIENCES INC</name>
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        <fairValLevel>1</fairValLevel>
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        <fairValLevel>3</fairValLevel>
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        <name>AVALYN PHARMA SER D CVT PFD STOCK PP</name>
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        <name>AVIDITY BIOSCIENCES INC</name>
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        <fairValLevel>1</fairValLevel>
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        <name>AXSOME THERAPEUTICS INC</name>
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        <fairValLevel>1</fairValLevel>
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        <name>BEAM THERAPEUTICS INC</name>
        <lei>N/A</lei>
        <title>BEAM THERAPEUTICS INC</title>
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        <assetCat>EC</assetCat>
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        <fairValLevel>1</fairValLevel>
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        <name>BEONE MEDICINES LTD</name>
        <lei>549300JFUK6FRD5MH739</lei>
        <title>BEONE MEDICINES LTD</title>
        <cusip>000000000</cusip>
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        <balance>8015396.000000</balance>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>CH</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>2</fairValLevel>
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        <name>BEONE MEDICINES LTD-ADR</name>
        <lei>549300JFUK6FRD5MH739</lei>
        <title>BEONE MEDICINES LTD</title>
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        <invCountry>KY</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
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        <name>BETA BIONICS INC</name>
        <lei>N/A</lei>
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        <fairValLevel>1</fairValLevel>
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        <name>BICARA THERAPEUTICS INC</name>
        <lei>N/A</lei>
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        <fairValLevel>1</fairValLevel>
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        <name>BICYCLE THERAPEUTICS PLC-ADR</name>
        <lei>213800XKUI6R7GKC3E43</lei>
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        <fairValLevel>1</fairValLevel>
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        <name>BIO-RAD LABORATORIES-A</name>
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        <name>BIO-TECHNE CORP</name>
        <lei>54930073RLKQ51TILZ35</lei>
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        <name>BIOGEN INC</name>
        <lei>W8J5WZB5IY3K0NDQT671</lei>
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        <name>BIOHAVEN LTD</name>
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        <name>BLUEJAY THERAPEUTICS SER C CVT PFD PP</name>
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        <name>BLUEJAY THERAPEUTICS SER C-1 CVT PFD PP</name>
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        <name>BOSTON SCIENTIFIC CORP</name>
        <lei>Y6ZDD9FP4P8JSSJMW954</lei>
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        <name>BridgeBio Oncology Therapeutics Inc</name>
        <lei>N/A</lei>
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      <invstOrSec>
        <name>BRIDGEBIO PHARMA INC</name>
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      <invstOrSec>
        <name>BRIGHTSPRING HEALTH SERVICES</name>
        <lei>N/A</lei>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>Cabaletta Bio Common WTS 09/26 PP</name>
        <lei>N/A</lei>
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        <fairValLevel>2</fairValLevel>
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      <invstOrSec>
        <name>CABALETTA BIO INC</name>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>CAPSULE CORP SERIES 1-D CVT PFD STOCK</name>
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        <fairValLevel>3</fairValLevel>
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      <invstOrSec>
        <name>CAPSULE CORP SERIES E CVT PFD STOCK PP</name>
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        <fairValLevel>3</fairValLevel>
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      <invstOrSec>
        <name>CARDINAL HEALTH INC</name>
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        <fairValLevel>1</fairValLevel>
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        <name>CARIS LIFE SCIENCES INC</name>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>CELCUITY INC</name>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>CELLANOME SERIES A CVT PFD STOCK PP</name>
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        <fairValLevel>3</fairValLevel>
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      <invstOrSec>
        <name>CELLDEX THERAPEUTICS INC</name>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>CENCORA INC</name>
        <lei>AI8GXW8LG5WK7E9UD086</lei>
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        <curCd>USD</curCd>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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        <name>CENTENE CORP</name>
        <lei>549300Z7JJ4TQSQGT333</lei>
        <title>CENTENE CORP</title>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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        <name>CENTESSA PHARMACEUTICALS-ADR</name>
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        <assetCat>EC</assetCat>
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        <invCountry>GB</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
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        <name>CG ONCOLOGY INC</name>
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        <fairValLevel>1</fairValLevel>
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        <name>NCHROMA BIO SER I CVT PFD STOCK PP</name>
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        <name>CHROMACODE INC PP</name>
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        <name>Chromacode INC SER AA CVT PFD STK PP</name>
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        <name>CHUGAI PHARMACEUTICAL CO LTD</name>
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        <name>CIGNA GROUP/THE</name>
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        <name>CLEAR LABS SERIES C CVT PFD PP</name>
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        <name>CLEERLY SER C CVT PFD STK PP</name>
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        <name>Climb Bio Inc</name>
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        <fairValLevel>2</fairValLevel>
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      <invstOrSec>
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        <name>IMMUNOME INC</name>
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        <name>INSITRO SER B CVT PFD PP</name>
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        <name>INSITRO SER C CVT PFD PP</name>
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      <invstOrSec>
        <name>INSMED INC</name>
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      <invstOrSec>
        <name>INTUITIVE SURGICAL INC</name>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>IONIS PHARMACEUTICALS INC</name>
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        <fairValLevel>1</fairValLevel>
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        <name>IOVANCE BIOTHERAPEUTICS INC</name>
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        <fairValLevel>1</fairValLevel>
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        <name>IQVIA HOLDINGS INC</name>
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        <name>JANUX THERAPEUTICS INC</name>
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        <name>KARDIUM INC SER D-5 CVT PFD STOCK PP</name>
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        <name>Kartos Therapeutics SR D CVT PFD STK PP</name>
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        <name>KESTRA MEDICAL TECHNOLOGIES</name>
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        <name>KYMERA THERAPEUTICS INC</name>
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        <name>KYVERNA THERAPEUTICS INC</name>
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        <name>Kardium Inc Series D-7 CVT PFD Stock PP</name>
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        <name>SAIL BIOMEDICINES SER B CVT PFD STOCK PP</name>
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      <invstOrSec>
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      <invstOrSec>
        <name>LENZ THERAPEUTICS INC</name>
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        <name>LUMICKS TECH SER D CVT PFD STOCK PP</name>
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        <name>MEDIWOUND LTD</name>
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        <fairValLevel>1</fairValLevel>
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        <name>MERUS NV</name>
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        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
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        <name>MONTE ROSA THERAPEUTICS INC</name>
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        <name>MOONLAKE IMMUNOTHERAPEUTICS</name>
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        <name>REVOLUTION MEDICINES INC WTS 12/26</name>
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        <isRestrictedSec>Y</isRestrictedSec>

        <fairValLevel>3</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>SANOFI ADR</name>
        <lei>549300E9PC51EN656011</lei>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>SARTORIUS AG-VORZUG PREF</name>
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        <fairValLevel>2</fairValLevel>
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      <invstOrSec>
        <name>SCHOLAR ROCK HOLDING CORP</name>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>SCRIBE THERA SER B CVT PFD STOCK PP</name>
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        <fairValLevel>3</fairValLevel>
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      <invstOrSec>
        <name>SEAPORT THERAPEUTICS SER B CVT PFD PP</name>
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        <fairValLevel>3</fairValLevel>
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      <invstOrSec>
        <name>SENSORION SA</name>
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        <fairValLevel>2</fairValLevel>
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      <invstOrSec>
        <name>SIONNA THERAPEUTICS INC</name>
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        <fairValLevel>1</fairValLevel>
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        <name>SOLENO THERAPEUTICS INC</name>
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        <name>SOMALOGIC INC WTS 8/26</name>
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      <invstOrSec>
        <name>SONOVA HOLDING AG-REG</name>
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        <fairValLevel>2</fairValLevel>
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        <name>Spyre Therapeutics Inc</name>
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        <name>STRUCTURE THERAPEUTICS INC ADR</name>
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        <fairValLevel>1</fairValLevel>
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        <name>STRYKER CORP</name>
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        <fairValLevel>1</fairValLevel>
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        <name>SUMMIT THERAPEUTICS INC</name>
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        <name>T. Rowe Price Government Reserve Fund</name>
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        <name>TARSUS PHARMACEUTICALS INC</name>
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        <name>TEMPUS AI INC</name>
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        <name>TENAX THERAPEUTICS PRE FUND WTS PIPE PP</name>
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        <name>TENET HEALTHCARE CORP</name>
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        <name>TESSERA THERAPEUTICS SER D CVT PFD PP</name>
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        <name>Treeline Bio Common WTS 8/35 PP</name>
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        <invCountry>US</invCountry>
        <isRestrictedSec>Y</isRestrictedSec>

        <fairValLevel>3</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>TREELINE BIO SER A CVT PFD STOCK PP</name>
        <lei>N/A</lei>
        <title>TREELINE BIO SER A CVT PFD STOCK PP</title>
        <cusip>000000000</cusip>
        <identifiers>
          <other otherDesc="Internal ID" value="TC0U9C2T7"/>
        </identifiers>
        <balance>2370150.000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>17271283.050000</valUSD>
        <pctVal>0.1568041500</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EP</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>Y</isRestrictedSec>

        <fairValLevel>3</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>TREELINE BIO SER A-1 CVT PFD STOCK PP</name>
        <lei>N/A</lei>
        <title>TREELINE BIO SER A-1 CVT PFD STOCK PP</title>
        <cusip>000000000</cusip>
        <identifiers>
          <other otherDesc="Internal ID" value="TC51XS4U9"/>
        </identifiers>
        <balance>2744291.000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>19997648.520000</valUSD>
        <pctVal>0.1815565334</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EP</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>Y</isRestrictedSec>

        <fairValLevel>3</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Treeline Bio SER A-2 NV CVT PFD PP</name>
        <lei>N/A</lei>
        <title>TREELINE BIO SER A-2 NV CVT PFD PP</title>
        <cusip>000000000</cusip>
        <identifiers>
          <other otherDesc="Internal ID" value="TC9QDVLP7"/>
        </identifiers>
        <balance>299448.000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>2182077.580000</valUSD>
        <pctVal>0.0198108513</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EP</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>Y</isRestrictedSec>

        <fairValLevel>3</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>TENAX THERAPEUTICS NEW WTS 8/29 PIPE PP</name>
        <lei>549300J03O6B1IJ2B606</lei>
        <title>Tenax Therapeutics, Inc</title>
        <cusip>000000000</cusip>
        <identifiers>
          <other otherDesc="Internal ID" value="TC9A9ADO5"/>
        </identifiers>
        <balance>1103045.000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1248371.180000</valUSD>
        <pctVal>0.0113338298</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>Y</isRestrictedSec>

        <fairValLevel>2</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>TESSERA THERAPEUTICS SER C' CVT PFD PP</name>
        <lei>N/A</lei>
        <title>Tessera Therapeutics, Inc. Series C</title>
        <cusip>000000000</cusip>
        <identifiers>
          <other otherDesc="Internal ID" value="TC7M24T72"/>
        </identifiers>
        <balance>674174.000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>3492221.320000</valUSD>
        <pctVal>0.0317055076</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>Y</isRestrictedSec>

        <fairValLevel>3</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>ULTRAGENYX PHARMACEUTICAL INC</name>
        <lei>529900EV44GVDN1DCX77</lei>
        <title>ULTRAGENYX PHARMACEUTICAL INC</title>
        <cusip>90400D108</cusip>
        <identifiers>
          <isin value="US90400D1081"/>
        </identifiers>
        <balance>592307.000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>17816594.560000</valUSD>
        <pctVal>0.1617549755</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>UNIQURE NV</name>
        <lei>724500RPCTZLFYJZ3S98</lei>
        <title>UNIQURE NV</title>
        <cusip>000000000</cusip>
        <identifiers>
          <isin value="NL0010696654"/>
        </identifiers>
        <balance>581982.000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>33970289.340000</valUSD>
        <pctVal>0.3084126599</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>NL</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>UNITED THERAPEUTICS CORP</name>
        <lei>5299005C4HZL4UWROC14</lei>
        <title>UNITED THERAPEUTICS CORP</title>
        <cusip>91307C102</cusip>
        <identifiers>
          <isin value="US91307C1027"/>
        </identifiers>
        <balance>201852.000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>84618376.920000</valUSD>
        <pctVal>0.7682412842</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>UNITEDHEALTH GROUP INC</name>
        <lei>549300GHBMY8T5GXDE41</lei>
        <title>UNITEDHEALTH GROUP INC</title>
        <cusip>91324P102</cusip>
        <identifiers>
          <isin value="US91324P1021"/>
        </identifiers>
        <balance>1306949.000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>451289489.700000</valUSD>
        <pctVal>4.0972094918</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>UROGEN PHARMA LTD</name>
        <lei>549300C0YCX7CG2G5D50</lei>
        <title>UROGEN PHARMA LTD</title>
        <cusip>000000000</cusip>
        <identifiers>
          <isin value="IL0011407140"/>
        </identifiers>
        <balance>262756.000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>5241982.200000</valUSD>
        <pctVal>0.0475914013</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>IL</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>VAXCYTE INC</name>
        <lei>254900M7NMHTGASX8D95</lei>
        <title>VAXCYTE INC</title>
        <cusip>92243G108</cusip>
        <identifiers>
          <isin value="US92243G1085"/>
        </identifiers>
        <balance>880978.000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>31732827.560000</valUSD>
        <pctVal>0.2880989814</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>VEEVA SYSTEMS INC CL A</name>
        <lei>549300YZEXPDB92M2F02</lei>
        <title>VEEVA SYSTEMS INC</title>
        <cusip>922475108</cusip>
        <identifiers>
          <isin value="US9224751084"/>
        </identifiers>
        <balance>192708.000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>57409640.280000</valUSD>
        <pctVal>0.5212160452</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>VERA THERAPEUTICS INC</name>
        <lei>N/A</lei>
        <title>VERA THERAPEUTICS INC</title>
        <cusip>92337R101</cusip>
        <identifiers>
          <isin value="US92337R1014"/>
        </identifiers>
        <balance>1277521.000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>37124760.260000</valUSD>
        <pctVal>0.3370517674</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>VERASTEM INC</name>
        <lei>549300IY0EFBIU8NQC81</lei>
        <title>VERASTEM INC</title>
        <cusip>92337C203</cusip>
        <identifiers>
          <isin value="US92337C2035"/>
        </identifiers>
        <balance>434632.000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>3837800.560000</valUSD>
        <pctVal>0.0348429849</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>VERILY LIFE SCIENCES LLC SER B UNITS PP</name>
        <lei>5493003ZYK1Z7M670M44</lei>
        <title>VERILY LIFE SCIENCES LLC SER B UNITS PP</title>
        <cusip>000000000</cusip>
        <identifiers>
          <other otherDesc="Internal ID" value="TC4V69U94"/>
        </identifiers>
        <balance>113564.000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>3747612.000000</valUSD>
        <pctVal>0.0340241725</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>Y</isRestrictedSec>

        <fairValLevel>3</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>VERTEX PHARMACEUTICALS INC</name>
        <lei>54930015RAQRRZ5ZGJ91</lei>
        <title>VERTEX PHARMACEUTICALS INC</title>
        <cusip>92532F100</cusip>
        <identifiers>
          <isin value="US92532F1003"/>
        </identifiers>
        <balance>659165.000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>258155380.600000</valUSD>
        <pctVal>2.3437653654</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>VIRIDIAN THERAPEUTICS INC</name>
        <lei>549300C775BNYF550E70</lei>
        <title>VIRIDIAN THERAPEUTICS INC</title>
        <cusip>92790C104</cusip>
        <identifiers>
          <isin value="US92790C1045"/>
        </identifiers>
        <balance>478324.000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>10322231.920000</valUSD>
        <pctVal>0.0937144506</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>VOYAGER THERAPEUTICS INC</name>
        <lei>54930082S4XVR0ZWCC74</lei>
        <title>VOYAGER THERAPEUTICS INC</title>
        <cusip>92915B106</cusip>
        <identifiers>
          <isin value="US92915B1061"/>
        </identifiers>
        <balance>332596.000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1553223.320000</valUSD>
        <pctVal>0.0141015501</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>WATERS CORP</name>
        <lei>5T547R1474YC9HOD8Q74</lei>
        <title>WATERS CORP</title>
        <cusip>941848103</cusip>
        <identifiers>
          <isin value="US9418481035"/>
        </identifiers>
        <balance>18779.000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>5630131.990000</valUSD>
        <pctVal>0.0511153722</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>WAVE LIFE SCIENCES LTD</name>
        <lei>54930070006GPKFYZ813</lei>
        <title>WAVE LIFE SCIENCES LTD</title>
        <cusip>000000000</cusip>
        <identifiers>
          <isin value="SG9999014716"/>
        </identifiers>
        <balance>855344.000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>6261118.080000</valUSD>
        <pctVal>0.0568440281</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>SG</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>XENCOR INC</name>
        <lei>549300V5IF65437JKG30</lei>
        <title>XENCOR INC</title>
        <cusip>98401F105</cusip>
        <identifiers>
          <isin value="US98401F1057"/>
        </identifiers>
        <balance>532245.000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>6243233.850000</valUSD>
        <pctVal>0.0566816591</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>ZAI LAB LTD ADR</name>
        <lei>549300P2UYQ9U5LY1T58</lei>
        <title>ZAI LAB LTD</title>
        <cusip>98887Q104</cusip>
        <identifiers>
          <isin value="US98887Q1040"/>
        </identifiers>
        <balance>737906.000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>25007634.340000</valUSD>
        <pctVal>0.2270416642</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>KY</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
    </invstOrSecs>
    <explntrNotes>
      <explntrNote note="Monthly returns presented in Item B.5(a) have been calculated without deducting any applicable sales loads or redemption fees." noteItem="B.5.a"/>
    </explntrNotes>
    <signature>
      <ncom:dateSigned>2025-11-05</ncom:dateSigned>
      <ncom:nameOfApplicant>T. ROWE PRICE HEALTH SCIENCES FUND, INC.</ncom:nameOfApplicant>
      <ncom:signature>/s/ Alan Dupski</ncom:signature>
      <ncom:signerName>Alan Dupski</ncom:signerName>
      <ncom:title>Treasurer &amp; Vice President</ncom:title>
    </signature>
  </formData>
  <documents>XXXX</documents>
</edgarSubmission>
