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Proc-Type: 2001,MIC-CLEAR
Originator-Name: webmaster@www.sec.gov
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MIC-Info: RSA-MD5,RSA,
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 MunEwT80o6SweU2bFeRI8Q==

<SEC-DOCUMENT>0001478630-09-000001.txt : 20091214
<SEC-HEADER>0001478630-09-000001.hdr.sgml : 20091214
<ACCEPTANCE-DATETIME>20091214180613
ACCESSION NUMBER:		0001478630-09-000001
CONFORMED SUBMISSION TYPE:	3
PUBLIC DOCUMENT COUNT:		1
CONFORMED PERIOD OF REPORT:	20091214
FILED AS OF DATE:		20091214
DATE AS OF CHANGE:		20091214

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			Burrin Paul
		CENTRAL INDEX KEY:			0001478630

	FILING VALUES:
		FORM TYPE:		3
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	000-27188
		FILM NUMBER:		091239955

	MAIL ADDRESS:	
		STREET 1:		10188 TELESIS COURT
		STREET 2:		SUITE 100
		CITY:			SAN DIEGO
		STATE:			CA
		ZIP:			92121

ISSUER:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			ACCELRYS, INC.
		CENTRAL INDEX KEY:			0001002388
		STANDARD INDUSTRIAL CLASSIFICATION:	SERVICES-PREPACKAGED SOFTWARE [7372]
		IRS NUMBER:				330557266
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			0331

	BUSINESS ADDRESS:	
		STREET 1:		10188 TELESIS COURT, SUITE 100
		CITY:			SAN DIEGO
		STATE:			CA
		ZIP:			92121-3752
		BUSINESS PHONE:		(858) 799-5000

	MAIL ADDRESS:	
		STREET 1:		10188 TELESIS COURT, SUITE 100
		CITY:			SAN DIEGO
		STATE:			CA
		ZIP:			92121-3752

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	PHARMACOPEIA INC
		DATE OF NAME CHANGE:	19951018
</SEC-HEADER>
<DOCUMENT>
<TYPE>3
<SEQUENCE>1
<FILENAME>primary_doc.xml
<DESCRIPTION>PRIMARY DOCUMENT
<TEXT>
<XML>
<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0203</schemaVersion>

    <documentType>3</documentType>

    <periodOfReport>2009-12-14</periodOfReport>

    <noSecuritiesOwned>0</noSecuritiesOwned>

    <issuer>
        <issuerCik>0001002388</issuerCik>
        <issuerName>ACCELRYS, INC.</issuerName>
        <issuerTradingSymbol>ACCL</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001478630</rptOwnerCik>
            <rptOwnerName>Burrin Paul</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>10188 TELESIS COURT</rptOwnerStreet1>
            <rptOwnerStreet2>SUITE 100</rptOwnerStreet2>
            <rptOwnerCity>SAN DIEGO</rptOwnerCity>
            <rptOwnerState>CA</rptOwnerState>
            <rptOwnerZipCode>92121</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>0</isDirector>
            <isOfficer>1</isOfficer>
            <isTenPercentOwner>0</isTenPercentOwner>
            <isOther>0</isOther>
            <officerTitle>SVP &amp; Chief Marketing Officer</officerTitle>
        </reportingOwnerRelationship>
    </reportingOwner>

    <nonDerivativeTable>
        <nonDerivativeHolding>
            <securityTitle>
                <value>Restricted stock units</value>
            </securityTitle>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>50000</value>
                    <footnoteId id="F1"/>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                </directOrIndirectOwnership>
            </ownershipNature>
        </nonDerivativeHolding>
    </nonDerivativeTable>

    <derivativeTable>
        <derivativeHolding>
            <securityTitle>
                <value>Non-qualified stock options</value>
            </securityTitle>
            <conversionOrExercisePrice>
                <value>5.5</value>
            </conversionOrExercisePrice>
            <exerciseDate>
                <value>2010-12-14</value>
                <footnoteId id="F2"/>
            </exerciseDate>
            <expirationDate>
                <value>2019-12-14</value>
            </expirationDate>
            <underlyingSecurity>
                <underlyingSecurityTitle>
                    <value>Common Stock</value>
                </underlyingSecurityTitle>
                <underlyingSecurityShares>
                    <value>100000</value>
                </underlyingSecurityShares>
            </underlyingSecurity>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                </directOrIndirectOwnership>
            </ownershipNature>
        </derivativeHolding>
    </derivativeTable>

    <footnotes>
        <footnote id="F1">The restricted stock units were granted on 12/14/09 and vest in equal annual installments over a three year period beginning on the date of grant.</footnote>
        <footnote id="F2">The Stock Options were granted on 12/14/09.  One-quarter of the shares vest upon the first anniversary of the date of grant and 1/48th of the shares vest monthly thereafter so that the option will be fully vested on the fourth anniversary of the date of grant.</footnote>
    </footnotes>

    <ownerSignature>
        <signatureName>Jamie Moxley, Attorney in Fact</signatureName>
        <signatureDate>2009-12-14</signatureDate>
    </ownerSignature>
</ownershipDocument>
</XML>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
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