Mail Stop 4561

      November 29, 2005

David M. Sankaran
Senior Vice President and
Chief Financial Officer
Accelrys, Inc.
10188 Telesis Court, Suite 100
San Diego, CA 92121


	Re:	Accelrys, Inc.
   Form 10-K for the Fiscal Year Ended
   March 31, 2005
		Filed June 13, 2005
		File No. 000-27188

Dear Mr. Sankaran:

      We have reviewed your response to our letter dated September
19, 2005 in connection with our review of the above referenced
filings and have the following comments.  Where indicated, we
think
you should revise your document in response to these comments.  If
you disagree, we will consider your explanation as to why our
comment
is inapplicable or a revision is unnecessary.  Please be as
detailed
as necessary in your explanation.  In some of our comments, we may
ask you to provide us with supplemental information so we may
better
understand your disclosure.  After reviewing this information, we
may
raise additional comments.

      Please understand that the purpose of our review process is
to
assist you in your compliance with the applicable disclosure
requirements and to enhance the overall disclosure in your filing.
We look forward to working with you in these respects.  We welcome
any questions you may have about our comments or any other aspect
of
our review.  Feel free to call us at the telephone numbers listed
at
the end of this letter.

Consolidated Statements of Cash Flows, page 47

1. Please refer to comment 1 of our letter dated September 19,
2005.
We note your response and believe that you must assess materiality
regarding the effect of presenting your statements of cash flows
to
include separate cash flow information for discontinued operations
for operating, investing and financing activities for each period
presented.  If you conclude that providing such information is
material, you must restate your financial statements.  Please
advise
as to your assessment of materiality, for all periods presented,
regarding the effect of not presenting this cash flow information
related to your discontinued operations.

Note 2. Significant Accounting Policies

Revenue Recognition, page 50

2. Please refer to comment 5 of our letter dated September 19,
2005.
We note your response regarding your customers` right to exchange
licensed software modules for other software modules.  Your
response
indicates that when a customer exercises their right to exchange,
for
example Module A for a Module B, they are no longer licensed to
use
the Module A.  Therefore, based on paragraph 50 of SOP 97-2, it
appears that paragraph 49 of SOP 97-2 (as cited in your response)
would not be the applicable guidance.  Rather, it appears that
these
transactions would qualify as exchanges or returns.  Please
explain.
Do these exchanged modules have no more than minimal differences
in
price, functionality, or features?  Explain how you analyzed these
rights pursuant to paragraphs 50 & 51 of SOP 97-2 and SFAS 48, as
applicable, and tell us how your accounting for such arrangement
complies with this guidance.

3. Please refer to comment 5 of our letter dated September 19,
2005.
We note that prior to the modification of your annual license
agreements, you believed that you established VSOE based on list
prices for PCS.  Additionally, we also note that the price for PCS
is
available separately if the customer is renewing PCS for a
perpetual
license and the price allocation for PCS purchased with a term-
based
license is based on the PCS renewal rate.  Finally, you state that
your term-based licenses are always co-terminus with the related
PCS.
Tell us how you considered TPA 5100.68 in recognizing revenue
related
to your term-based licenses up-front.  In this regard, if your
term-
based licenses and the related PCS services are co-terminus, it is
difficult to established VSOE of the PCS services as the PCS
services
have not been sold separately.  Additionally, while TPA 5100.68
does
not address one-year time based licenses, note that the PCS
renewal
terms in a perpetual license cannot be used to provide VSOE of
fair
value of PCS bundled with a one-year term license.  Please advise
to
clarify.

4. Please refer to comment 6 of our letter dated September 19,
2005.
Tell us whether your consortia agreements involve significant
production, modification or customization of your existing
software
(i.e. initial software library) and if so, how you considered SOP
81-
1 in recognizing revenue for the entire arrangement.  If the
consortia agreements do not involve significant production,
modification or customization of your existing software, please
explain the reasons why the consortia members are required to
license
your initial software library and also how you considered whether
the
license fee represents an up-front fee associated with the
development services to be provided.  Also, according to Note 2,
consortium fees are recognized on a straight-line basis over the
term
of the agreement.  Do the membership fees also include the
licenses
for the software?  If so, tell us how you account for each element
of
the arrangement (i.e. the license, the membership) and tell us how
you determined VSOE.  Please advise.

      * * * * *

      As appropriate, please amend your filing and respond to
these
comments within 10 business days or tell us when you will provide
us
with a response.  Please submit all correspondence and
supplemental
materials on EDGAR as required by Rule 101 of Regulation S-T.  You
may wish to provide us with marked copies of any amendment to
expedite our review.  Please furnish a cover letter with any
amendment that keys your responses to our comments and provides
any
requested information.  Detailed cover letters greatly facilitate
our
review.  Please understand that we may have additional comments
after
reviewing any amendment and your responses to our comments.

	You may contact Patrick Gilmore at (202) 551-3406 or me at
(202)
551-3499 if you have questions regarding comments on the financial
statements and related matters.

							Sincerely,


							Kathleen Collins
							Accounting Branch Chief

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David M. Sankaran
Accelrys, Inc.
November 29, 2005
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