PROSPECTUS SUPPLEMENT                          Filed pursuant to Rule 424(b)(3)
To Prospectus Dated September 16, 1996,              Registration No. 333-08269
As Supplemented to Date

                                  $100,000,000

                                PHYMATRIX CORP.

              6-3/4% Convertible Subordinated Debentures due 2003
                                      and
               Shares of Common Stock, Par Value $.01 Per Share,
                        Issuable Upon Conversion Thereof


     This Prospectus Supplement (the "Supplement") relates to the resale by
Smith Barney & Co. ("Smith Barney") of up to $950,000 aggregate principal amount
of 6-3/4% Convertible Subordinated Debentures due 2003 (the "Debentures") of
PhyMatrix Corp., a Delaware corporation (the "Company"), originally issued in
private placements consummated on June 26, 1996 (the "Debt Offering"), pursuant
to PhyMatrix Corp.'s Registration Statement on Form S-1 (No. 333-08269) (the
"Registration Statement"). This Supplement should be read in conjunction with
the Prospectus dated September 16, 1996, as supplemented to date (the
"Prospectus"), to be delivered with this Supplement. All capitalized terms used
but not defined in this Supplement shall have the meanings given them in the
Prospectus.

     Based on information provided to the Company, the aggregate principal
amount of the Debentures that are currently beneficially owned by Smith Barney
is $4,440,000, of which $950,000 may be sold at this time pursuant to the
Prospectus as supplemented hereby. Additional information concerning the Selling
Securityholders (including Smith Barney) may be set forth from time to time in
additional supplements to the Prospectus. The total outstanding aggregate
principal amount of the Debentures is $100,000,000.

     The closing price of the Company's Common Stock as reported on The
Nasdaq National Market on December 4, 1996 was $15.6875 per share.

     The Debentures will be subordinated to all existing and future Senior
Indebtedness of the Company. At July 31, 1996, Senior Indebtedness was 
approximately $7.3 million. The Indenture contains no limitations on the
incurrence of additional indebtedness or other liabilities by the Company.

     The Debentures are neither listed on a national securities exchange nor
quoted on an automated quotation system. However, the Debentures are eligible
for trading in the Private Offerings, Resales and Trading through Automated
Linkages ("PORTAL") Market. Debentures sold pursuant to the Registration
Statement will no longer be eligible for trading in the PORTAL Market.

     The date of this Prospectus Supplement is December 4, 1996.