<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0306</schemaVersion>

    <documentType>4</documentType>

    <periodOfReport>2020-10-15</periodOfReport>

    <issuer>
        <issuerCik>0001196298</issuerCik>
        <issuerName>NEPHROS INC</issuerName>
        <issuerTradingSymbol>NEPH</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001048462</rptOwnerCik>
            <rptOwnerName>WEXFORD CAPITAL LP</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>777 SOUTH FLAGLER DRIVE, SUITE 602 EAST</rptOwnerStreet1>
            <rptOwnerStreet2></rptOwnerStreet2>
            <rptOwnerCity>WEST PALM BEACH</rptOwnerCity>
            <rptOwnerState>FL</rptOwnerState>
            <rptOwnerZipCode>33401</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>true</isDirector>
            <isTenPercentOwner>true</isTenPercentOwner>
        </reportingOwnerRelationship>
    </reportingOwner>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001472112</rptOwnerCik>
            <rptOwnerName>Wexford GP LLC</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>C/O WEXFORD CAPITAL LP</rptOwnerStreet1>
            <rptOwnerStreet2>777 SOUTH FLAGLER DRIVE, SUITE 602 EAST</rptOwnerStreet2>
            <rptOwnerCity>WEST PALM BEACH</rptOwnerCity>
            <rptOwnerState>FL</rptOwnerState>
            <rptOwnerZipCode>44302</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>true</isDirector>
            <isTenPercentOwner>true</isTenPercentOwner>
        </reportingOwnerRelationship>
    </reportingOwner>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001001391</rptOwnerCik>
            <rptOwnerName>DAVIDSON CHARLES E</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>C/O WEXFORD CAPITAL LP</rptOwnerStreet1>
            <rptOwnerStreet2>777 SOUTH FLAGLER DRIVE, SUITE 602 EAST</rptOwnerStreet2>
            <rptOwnerCity>WEST PALM BEACH</rptOwnerCity>
            <rptOwnerState>FL</rptOwnerState>
            <rptOwnerZipCode>33401</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>true</isDirector>
            <isTenPercentOwner>true</isTenPercentOwner>
        </reportingOwnerRelationship>
    </reportingOwner>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001048485</rptOwnerCik>
            <rptOwnerName>JACOBS JOSEPH</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>C/O WEXFORD CAPITAL LP</rptOwnerStreet1>
            <rptOwnerStreet2>777 SOUTH FLAGLER DRIVE, SUITE 602 EAST</rptOwnerStreet2>
            <rptOwnerCity>WEST PALM BEACH</rptOwnerCity>
            <rptOwnerState>FL</rptOwnerState>
            <rptOwnerZipCode>33401</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>true</isDirector>
            <isTenPercentOwner>true</isTenPercentOwner>
        </reportingOwnerRelationship>
    </reportingOwner>

    <nonDerivativeTable>
        <nonDerivativeTransaction>
            <securityTitle>
                <value>Common Stock, par value $0.001</value>
            </securityTitle>
            <transactionDate>
                <value>2020-10-15</value>
            </transactionDate>
            <transactionCoding>
                <transactionFormType>4</transactionFormType>
                <transactionCode>A</transactionCode>
                <equitySwapInvolved>0</equitySwapInvolved>
            </transactionCoding>
            <transactionAmounts>
                <transactionShares>
                    <value>166667</value>
                    <footnoteId id="F1"/>
                </transactionShares>
                <transactionPricePerShare>
                    <value>6</value>
                </transactionPricePerShare>
                <transactionAcquiredDisposedCode>
                    <value>A</value>
                </transactionAcquiredDisposedCode>
            </transactionAmounts>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>3605471</value>
                    <footnoteId id="F2"/>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>I</value>
                </directOrIndirectOwnership>
                <natureOfOwnership>
                    <value>See footnotes</value>
                    <footnoteId id="F4"/>
                    <footnoteId id="F5"/>
                </natureOfOwnership>
            </ownershipNature>
        </nonDerivativeTransaction>
        <nonDerivativeHolding>
            <securityTitle>
                <value>Common Stock, par value $0.001</value>
            </securityTitle>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>1325</value>
                    <footnoteId id="F3"/>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>I</value>
                </directOrIndirectOwnership>
                <natureOfOwnership>
                    <value>See footnotes</value>
                    <footnoteId id="F4"/>
                    <footnoteId id="F5"/>
                </natureOfOwnership>
            </ownershipNature>
        </nonDerivativeHolding>
    </nonDerivativeTable>

    <footnotes>
        <footnote id="F1">Represents the common stock of the Issuer acquired by Wexford Spectrum Trading Limited (&quot;WST&quot;) in a registered direct offering, as described in the Issuer's Form 8-K, filed by the Issuer with the U.S. Securities and Exchange Commission on October 16, 2020.</footnote>
        <footnote id="F2">Represents the common stock of the Issuer held in the aggregate by WST, Wexford Partners 11, L.P., (&quot;WP11&quot;), WPIC 2 LLC (&quot;WPIC2&quot;, and together with WP11 and WST, the &quot;Wexford Entities&quot;) and Wexford Capital LP (&quot;Wexford Capital&quot;).</footnote>
        <footnote id="F3">Represents the common stock of the Issuer held by Wexford 11 Advisors LLC (&quot;WP Advisors&quot;).</footnote>
        <footnote id="F4">Wexford Capital may, by reason of its status as (i) sub-advisor of WST, (ii) investment manager of WP11 and (iii) manager of WPIC2, be deemed to own beneficially the securities held by the Wexford Entities. Wexford GP LLC (&quot;Wexford GP&quot;) may, as the General Partner of Wexford Capital, be deemed to own beneficially the securities held by the Wexford Entities. Each of Charles E. Davidson (&quot;Davidson&quot;) and Joseph M. Jacobs (&quot;Jacobs&quot;, and together with Wexford Capital, Wexford GP and Davidson, the &quot;Reporting Persons&quot;) may, by reason of his status as a controlling person of Wexford GP and Wexford Advisors, be deemed to own beneficially the securities held by the Wexford Entities and Wexford Advisors.</footnote>
        <footnote id="F5">Each of Wexford Capital, Wexford GP, Davidson and Jacobs share the power to vote and to dispose of the securities beneficially owned by the Wexford Entities.  Each of Davidson and Jacobs share the power to vote and to dispose of the securities beneficially owned by Wexford Advisors. Each of Wexford Capital, Wexford GP, Davidson and Jacobs disclaim beneficial ownership of the securities owned by the Wexford Entities and/or Wexford Advisors, as applicable, and this report shall not be deemed as an admission that they are the beneficial owners of such securities, except to the extent of any pecuniary interests therein. The Reporting Persons may be deemed to be directors by deputization by virtue of Arthur Amron and Paul Mieyal, each an employee of Wexford Capital, serving as directors of the Issuer.</footnote>
    </footnotes>

    <remarks>Shares previously reported as being beneficially owned by Lambda Investors LLC (&quot;Lambda&quot;) were distributed in kind and pro rata to Wexford Partners 11, L.P., WPIC 2 LLC and Wexford 11 Advisors LLC, the sole members of Lambda, on December 31, 2019.</remarks>

    <ownerSignature>
        <signatureName>Wexford Capital LP, By: Wexford GP LLC, its general partner, By: Arthur Amron, Vice President and Assistant Secretary</signatureName>
        <signatureDate>2020-10-16</signatureDate>
    </ownerSignature>

    <ownerSignature>
        <signatureName>Wexford GP LLC, By: Arthur Amron, Vice President and Assistant Secretary</signatureName>
        <signatureDate>2020-10-16</signatureDate>
    </ownerSignature>

    <ownerSignature>
        <signatureName>Charles E. Davidson</signatureName>
        <signatureDate>2020-10-16</signatureDate>
    </ownerSignature>

    <ownerSignature>
        <signatureName>Joseph M. Jacobs</signatureName>
        <signatureDate>2020-10-16</signatureDate>
    </ownerSignature>
</ownershipDocument>
