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ORGANIZATION AND SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES (Details Narrative) - USD ($)
$ in Thousands
3 Months Ended
Mar. 31, 2019
Mar. 31, 2018
Dec. 31, 2018
Accounting Policies [Abstract]      
Accumulated deficit $ (563,501)   $ (528,345)
Restricted cash and investments 1,200   1,200
Prepaid research and development $ 11,120   $ 9,691
Potentially dilutive securities excluded from calculation 6,768,530 4,660,180