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ORGANIZATION AND SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES (Details Narrative) - USD ($)
3 Months Ended
Mar. 31, 2017
Mar. 31, 2016
Dec. 31, 2016
Accounting Policies [Abstract]      
Accumulated deficit $ (264,114,329)   $ (236,386,820)
Antidilutive Securities Excluded from Computation of Earnings Per Share, Amount 3,634,008 6,869,500  
Cash, Cash Equivalents, and Short-term Investments, Total $ 109,500,000    
Restricted Cash and Investments 600,000   600,000
Prepaid Manufacturing $ 8,400,000   $ 5,700,000