INCOME TAXES (Details 1) - USD ($)	12 Months Ended
	Dec. 31, 2016	Dec. 31, 2015	Dec. 31, 2014
Income Tax Disclosure [Abstract]
Loss before income taxes, as reported in the consolidated statements of operations	$ (78,252,894)	$ (62,948,646)	$ (55,781,277)
Computed "expected" tax benefit	(26,605,984)	(21,402,540)	(18,965,634)
Increase (decrease) in income taxes resulting from:
Expected benefit from state and local taxes	(835,072)	(672,306)	(2,533,156)
Research and development credits	(2,364,417)	(1,603,364)	(1,092,767)
Other	(7,506)	566,310	35,459
Permanent difference related to contingent note payable	0	0	(244,814)
Impact of change in state tax rates on deferred taxes	0	5,836,819	0
Change in the balance of the valuation allowance for deferred tax assets	29,812,979	17,275,081	22,800,912
Income Tax Expense (Benefit)	$ 0	$ 0	$ 0