Condensed Consolidated Statements of Cash Flows - USD ($) $ in Thousands	12 Months Ended
Dec. 31, 2022	Dec. 31, 2021	Dec. 31, 2020
CASH FLOWS FROM OPERATING ACTIVITIES
Net loss	$ (198,335)	$ (348,101)	$ (279,381)
Adjustments to reconcile net loss to net cash used in operating activities:
Total compensation expense associated with restricted stock grants	19,185	61,274	80,289
Depreciation and amortization	303	282	158
Amortization of premium on investment securities		517
Amortization of premium (discounts) on investment securities	(331)		(30)
Amortization of debt issuance costs	1,844	1,080	925
Amortization of leasehold interest	212	212	216
Noncash change in lease liability and right of use asset	2,715	1,896	2,325
Change in fair value of notes payable	(116)	(578)	748
Changes in assets and liabilities:
Decrease (increase) in other current assets	8,181	(8,508)	2,257
Decrease (increase) in accounts receivable	1,389	(1,389)
(Decrease) increase in accounts payable and accrued expenses	(11,010)	15,991	11,631
Decrease in lease liabilities	(2,332)	(2,012)	(1,988)
Increase (decrease) in other current liabilities	2,277	(16,146)	(31,505)
Decrease in deferred revenue	(152)	(152)	(152)
Net cash used in operating activities	(176,170)	(295,634)	(214,507)
CASH FLOWS FROM INVESTING ACTIVITIES
Proceeds from maturity of short-term securities	87,275	55,600	43,250
Investment in held-to-maturity securities	(107,274)	(55,531)	(67,403)
Purchases of PPE	(14)	(401)	(357)
Net cash used in investing activities	(20,013)	(332)	(24,510)
CASH FLOWS FROM FINANCING ACTIVITIES
Payment of loan payable	(975)	(30,000)
Proceeds from sale of common stock, net		2,219	679,680
Proceeds from exercise of options	584	216	147
Offering costs paid		(1,016)
Proceeds from debt financings		70,000
Net cash used in financing activities	(391)	41,419	679,827
NET DECREASE IN CASH, CASH EQUIVALENTS AND RESTRICTED CASH	(196,574)	(254,547)	440,810
CASH, CASH EQUIVALENTS AND RESTRICTED CASH AT BEGINNING OF PERIOD	300,151	554,698	113,888
CASH, CASH EQUIVALENTS AND RESTRICTED CASH AT END OF PERIOD	$ 103,577	$ 300,151	$ 554,698

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