Condensed Consolidated Statements of Operations - USD ($) $ in Thousands	3 Months Ended		6 Months Ended
	Jun. 30, 2022	Jun. 30, 2021	Jun. 30, 2022	Jun. 30, 2021
Revenue:
Total revenue	$ 594	$ 1,545	$ 2,610	$ 2,338
Costs and expenses:
Cost of product revenue	23	148	260	288
Research and development:
Noncash compensation	2,328	7,016	4,223	14,527
Other research and development	24,546	37,855	70,693	93,438
Total research and development	26,874	44,871	74,916	107,965
Selling, general and administrative:
Noncash compensation	(3,304)	9,288	(3,077)	18,395
Other selling, general and administrative	15,942	24,729	36,324	42,384
Total selling, general and administrative	12,638	34,017	33,247	60,779
Total costs and expenses	39,535	79,036	108,423	169,032
Operating loss	(38,941)	(77,492)	(105,813)	(166,694)
Other expense (income):
Interest expense	3,017	1,623	5,681	3,521
Other income	(1,448)	(618)	(1,971)	(1,090)
Total other expense (income), net	1,569	1,005	3,710	2,431
Net loss	$ (40,510)	$ (78,497)	$ (109,523)	$ (169,125)
Basic net loss per common share (in dollars per share)	$ (0.30)	$ (0.59)	$ (0.81)	$ (1.28)
Diluted net loss per common share (in dollars per share)	$ (0.30)	$ (0.59)	$ (0.81)	$ (1.28)
Weighted-average shares used in computing basic net loss per common share (in shares)	134,779,904	132,072,996	134,591,250	131,986,293
Weighted-average shares used in computing diluted net loss per common share (in shares)	134,779,904	132,072,996	134,591,250	131,986,293
Product revenue, net [Member]
Revenue:
Total revenue	$ 556	$ 1,507	$ 2,534	$ 2,262
License revenue [Member]
Revenue:
Total revenue	$ 38	$ 38	$ 76	$ 76