Document And Entity Information [Abstract] Document Type Document Annual Report Document Period End Date Document Transition Report Entity File Number Entity Registrant Name Entity Incorporation, State or Country Code Entity Tax Identification Number Entity Address, Address Line One Entity Address, Address Line Two Entity Address, City or Town Entity Address, State or Province Entity Address, Postal Zip Code City Area Code Local Phone Number Title of 12(b) Security Trading Symbol Security Exchange Name Entity Well-known Seasoned Issuer Entity Voluntary Filers Entity Current Reporting Status Entity Interactive Data Current 1 Entity Interactive Data Current Entity Filer Category ICFR Auditor Attestation Flag Entity Small Business Entity Emerging Growth Company Entity Shell Company Entity Public Float Entity Common Stock, Shares Outstanding Entity Central Index Key Current Fiscal Year End Date Document Fiscal Year Focus Document Fiscal Period Focus Amendment Flag Auditor name Auditor firm ID Auditor location Condensed Consolidated Balance Sheets Assets Current assets: Cash and cash equivalents Short-term investment securities Receivables, Net, Current Accounts receivable, net Sum of the amounts paid in advance for capitalized costs that will be expensed with Research and development. Prepaid research and development Other current assets Assets, Current Total current assets Restricted Cash, Noncurrent Restricted cash Long-term Investments Long-term investment securities Operating Lease, Right-of-Use Asset Right of use assets Leasehold interest, net Equipment, net Goodwill Assets [Default Label] Total assets Liabilities and stockholders' equity Current liabilities: Accounts payable and accrued expenses Other Liabilities, Current Other current liabilities Long-term Debt, Current Maturities Less: Current portion Loan payable - current portion Operating Lease, Liability, Current Lease liability - current portion Lease liability current portion Accrued compensation Liabilities, Current Total current liabilities Deferred revenue, net of current portion Long-term Debt, Excluding Current Maturities Loan payable - non-current Loan payable non-current Operating Lease, Liability, Noncurrent Lease liability - non-current Lease liability non-current Liabilities Total liabilities Commitments and contingencies. Commitments and contingencies Stockholders' equity: Common stock, $0.001 par value per share (150,000,000 shares authorized, 110,209,293 and 109,425,243 shares issued, 110,167,984 and 109,383,934 shares outstanding at March 31, 2020 and December 31, 2019, respectively) Common stock, $0.001 par value per share (175,000,000 shares authorized, 143,292,043 and 140,617,606 shares issued, 143,250,734 and 140,576,297 shares outstanding at December 31, 2021 and December 31, 2020, respectively) Additional paid-in capital Treasury Stock, Value Treasury stock, at cost, 41,309 shares at December 31, 2021 and December 31, 2020 Treasury stock amount Accumulated deficit Accumulated deficit Stockholders' Equity, Including Portion Attributable to Noncontrolling Interest Balance Balance Total stockholders' equity Liabilities and Equity Total liabilities and stockholders' equity Common stock, par value Common stock, par value (in dollars per share) Common stock, shares authorized Common Stock, Shares Authorized Common stock, shares issued Common stock, shares outstanding Treasury stock, shares Treasury stock shares Condensed Consolidated Statements of Operations Statement [Table] Product and Service [Axis] Product and Service [Domain] Product revenue, net [Member] License revenue [Member] Statement [Line Items] Revenue: Revenue Total revenue Costs and expenses: The aggregat cost of product revenue during the reporting period. Cost of Product Revenue Cost of product revenue Research and development: n/a. Non-cash stock expense associated with in licensing agreements Noncash stock expense associated with in-licensing agreements The aggregate compensation expense related to the grants of stock options and restricted stock that is attributable to research and development expenses during the reporting period. Noncash compensation Other research and development Eligible payments to be received Other research and development Research and Development Expense Total research and development Selling, General and Administrative Expense [Abstract] Selling, general and administrative: The aggregate compensation expense related to the grants of stock options and restricted stock that is attributable to selling general and administrative expenses during the reporting period. Non Cash Compensation Selling General And Administrative Expenses Noncash compensation Other Selling, General and Administrative Expense Other selling, general and administrative Selling, General and Administrative Expense Total selling, general and administrative Total costs and expenses Total costs and expenses Operating Income (Loss) Operating loss Other (income) expense: Other expense (income): Interest Expense Interest expense Other Income Other income Nonoperating Income (Expense) Total other expense (income), net Net loss Net loss Net loss Basic and diluted net loss per common share (in dollars per share) Weighted average shares used in computing basic and diluted net loss per common share (in shares) Condensed Consolidated Statements of Changes in Stockholders' (Deficit) Equity Equity Components [Axis] Equity Component [Domain] Common Stock [Member] Additional Paid-in Capital [Member] Treasury Stock [Member] Accumulated Deficit [Member] Shares, Outstanding Balance (in shares) Balance (in shares) Stock Issued During Period, Value, Stock Options Exercised Issuance of common stock in connection with exercise of options Share-based Compensation Arrangement by Share-based Payment Award, Options, Exercises in Period Number of shares, Exercised/Vested Issuance of common stock in connection with exercise of options Issuance of restricted stock Issuance of restricted stock (in shares) Debt Conversion, Converted Instrument, Amount Warrants issued with debt financing Forfeiture of restricted stock Forfeiture of restricted stock Stock Issued During Period, Shares, Restricted Stock Award, Forfeited Forfeiture of restricted stock (in shares) Specific incremental costs directly attributable to a proposed or actual offering of securities. Offering Costs Offering costs Offering costs paid Issuance of common stock in public offering Issuance of common stock in public offering (in shares) Shares issued Refers to issuance of common stock in at market offering, net of offering costs. Issuance Of Common Stock In At Market Offering Net Of Offering Costs Issuance of common stock in At-the-Market offerings (net of offering costs) Refers to issuance of common stock in at market offering, in shares. Issuance Of Common Stock In At Market Offering Net Of Offering Costs, Shares Issuance of common stock in At-the-Market offerings (net of offering costs) (in shares) Compensation in respect of restricted stock granted to employees, directors and consultants Value of shares issued in connection with in-licensing agreement. Stock Issued During Period Value In Licensing Agreements Shares issued in connection with in-licensing agreements n/a. Shares Issued In Connection With In Licensing Agreements Shares issued in connection with in-licensing agreements (in shares) Specific incremental costs directly attributable to a At-the-Market offering of securities which are deferred at the end of the reporting period. Offering Costs At Market Offering costs, at market Condensed Consolidated Statements of Cash Flows CASH FLOWS FROM OPERATING ACTIVITIES Adjustments to reconcile net loss to net cash used in operating activities: Share-based Compensation, Total Noncash stock compensation expense Stock-based compensation expense The value of shares issued in connection with in-licensing agreement. Shares Issued In Connection With In Licensing Agreement Shares issued in connection with in-licensing agreement Depreciation and amortization Depreciation and amortization Amortization of premium on investment securities Amortization of premium on investment securities Investment Income, Amortization of Discount Amortization of premium on investment securities Amortization of Debt Issuance Costs Amortization of debt issuance costs Amortization of Lease Incentives Amortization of leasehold interest Right-of-Use Asset Obtained in Exchange for Operating Lease Liability Noncash change in lease liability and right of use asset The change in fair value of notes payable during the period. Change In Fair Value Of Notes Payable Change in fair value of notes payable Changes in assets and liabilities: Increase (Decrease) in Other Current Assets (Increase) decrease in other current assets Increase (Decrease) in Accounts Receivable Increase in accounts receivable Increase (decrease) in accounts payable and accrued expenses Increase in other liabilities (Decrease) increase in lease liabilities Increase (Decrease) in Other Current Liabilities Decrease (increase) in other liabilities Decrease in deferred revenue Net Cash Provided by (Used in) Operating Activities, Continuing Operations Net cash used in operating activities CASH FLOWS FROM INVESTING ACTIVITIES The cash inflow associated with the maturities of held-to-maturity securities. Proceeds from maturity of short-term securities Amount of cash outflow (inflow) through acquisition (sale) of short-term held-to-maturity securities. Payments To Acquire Held To Maturity Securities Short Term Investment in held-to-maturity securities Payments to Acquire Property, Plant, and Equipment Purchases of equipment Net Cash Provided by (Used in) Investing Activities, Continuing Operations Net cash (used in) provided by investing activities CASH FLOWS FROM FINANCING ACTIVITIES Proceeds from (Repayments of) Secured Debt Payment of loan payable Represents the net proceeds from issuance of common stock over-allotments during the period. Proceeds from sale of common stock, net Proceeds from the exercise of warrants Proceeds from exercise of options Proceeds from Other Debt Proceeds from debt financings Payments of Financing Costs Financing costs paid Net Cash Provided by (Used in) Financing Activities, Continuing Operations Net cash (used in) provided by financing activities Cash and Cash Equivalents, Period Increase (Decrease) NET (DECREASE) INCREASE IN CASH, CASH EQUIVALENTS AND RESTRICTED CASH Cash, Cash Equivalents, Restricted Cash and Restricted Cash Equivalents CASH, CASH EQUIVALENTS AND RESTRICTED CASH AT END OF PERIOD CASH, CASH EQUIVALENTS AND RESTRICTED CASH AT BEGINNING OF PERIOD Total cash, cash equivalents and restricted cash Reconciliation to amounts on condensed consolidated balance sheets: Reconciliation to amounts on consolidated balance sheets: Restricted cash Interest Paid, Including Capitalized Interest, Operating and Investing Activities [Abstract] Cash paid for: Interest Paid, Excluding Capitalized Interest, Operating Activities Interest NONCASH TRANSACTIONS Amount of Accrued Financing Costs. Accrued Financing Costs Deferred financing costs Amount of Warrants Issued With Debt Financing. Warrants Issued With Debt Financing Warrants issued with debt financing Amount of Shares Issued In Connection With In Licensing Agreements Value Shares Issued in Connection with in Licensing Agreements Value Shares issued in connection with in-licensing ORGANIZATION AND SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES Organization Consolidation And Presentation Of Financial Statements Disclosure And Significant Accounting Policies [Text Block] ORGANIZATION AND SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES REVENUE RECOGNITION. PRODUCT REVENUE, NET REVENUE RECOGNITION INVESTMENT SECURITIES Investments in Debt and Marketable Equity Securities (and Certain Trading Assets) Disclosure [Text Block] INVESTMENT SECURITIES FAIR VALUE MEASUREMENTS Fair Value Disclosures [Text Block] FAIR VALUE MEASUREMENTS STOCKHOLDERS' EQUITY Shareholders' Equity and Share-based Payments [Text Block] STOCKHOLDERS' EQUITY LOAN PAYABLE Long-term Debt [Text Block] LOAN PAYABLE LEASES Lessee, Operating Leases [Text Block] LEASES INCOME. TAXES. Income Tax Disclosure [Text Block] INCOME TAXES License Agreement [Abstract] LICENSE AGREEMENTS The entire disclosure for research, development, and License Agreement activities, including contracts and arrangements to be performed for others and with federal government. License Agreement Disclosure [Text Block] LICENSE AGREEMENTS RELATED PARTY TRANSACTIONS Related Party Transactions Disclosure [Text Block] RELATED PARTY TRANSACTIONS COMMITMENTS AND CONTINGENCIES Commitments and Contingencies Disclosure [Text Block] COMMITMENTS AND CONTINGENCIES Reflects the description of business of the entity. Description of Business Disclosure of accounting policy for reporting when there is a substantial doubt about an entity's ability to continue as a going concern for a reasonable period of time (generally a year from the balance sheet date). Disclose: (a) pertinent conditions and events giving rise to the assessment of substantial doubt about the entity's ability to continue as a going concern for a reasonable period of time, (b) the possible effects of such conditions and events, (c) management's evaluation of the significance of those conditions and events and any mitigating factors, (d) possible discontinuance of operations, (e) management's plans (including relevant prospective financial information), and (f) information about the recoverability or classification of recorded asset amounts or the amounts or classification of liabilities. Liquidity and Capital Resources Revenue Recognition Basic and Diluted Net Loss Per Common Share Basic and Diluted Net Loss Per Common Share Recently Issued Accounting Standards Recently Adopted Accounting Pronouncements Use of Estimates Cash and Cash Equivalents. Cash and Cash Equivalents Cash and Cash Equivalents, Restricted Cash and Cash Equivalents Restricted Cash Investment Securities. Investment Securities Credit Risk Research and Development Costs Income Taxes. Income Taxes Stock-Based Compensation Impairment or Disposal of Long-Lived Assets, Including Intangible Assets, Policy [Policy Text Block] Long-Lived Assets and Goodwill Dilutive securities excluded from computation Schedule of Antidilutive Securities Excluded from Computation of Earnings Per Share Disaggregation of Revenue [Table Text Block] Reconciliation of gross product sales to net product sales by each significant category of gross-to-net adjustments Held-to-maturity Securities Schedule of held-to-maturity securities Fair Value, Liabilities Measured on Recurring and Nonrecurring Basis Schedule of fair value, liabilities measured on recurring and nonrecurring basis Change In Level Three Fair Value During Period Schedule of change in level three fair value during period Schedule of Share-based Compensation, Stock Options, Activity Summary of activity for stock options Schedule of Assumptions Used [Table Text Block] Schedule of Fair Value Assumptions Schedule of Nonvested Restricted Stock Units Activity No definition available. Schedule Of Long Term Debt Key Assumptions [Table] [Text Block] Schedule of key assumptions No definition available. Schedule Of Long Term Debt [Text Block] Schedule of loan payable Lease, Cost [Table Text Block] Schedule of lease cost Tabular disclosure for balance sheet classification of lease liabilities. Schedule Of Balance Sheet Classification Of Operating Lease [Table Text Block] Schedule of classification of lease liabilities Lessee, Operating Lease, Liability, Maturity [Table Text Block] Schedule of lease liability maturity Schedule of Deferred Tax Assets and Liabilities Schedule of Effective Income Tax Rate Reconciliation Schedule of Loss Contingencies by Contingency Cash, Cash Equivalents, and Short-term Investments Cash and cash equivalents, and investment securities Restricted Cash and Investments Restricted cash pledge Goodwill, Impairment Loss Impairment to goodwill Organization, Consolidation and Presentation of Financial Statements [Abstract] Antidilutive Securities [Axis] Antidilutive Securities, Name [Domain] Restricted stock No definition available. Options [Member] Warrants [Member] Share Issuable Upon Note Conversion [Member] Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items] Antidilutive securities excluded from computation of diluted loss per share Potentially dilutive securities excluded from calculation Gross revenue Revenue Gross Gross product revenue Administrative Fees Expense Chargebacks and administrative fees Refers to trade discount and allowances. Trade Discounts and allowances Trade discounts and allowances Refers to trade discount and allowances. Government Rebates and Co-Payment Assistance Government rebates and co-payment assistance Refers to revenue sales returns and allowances. Sales Returns and Allowances Sales returns and allowances Refers to revenue gross to net adjustments. Gross to Net Adjustments Total gross-to-net adjustments Net Product Revenue Net Product Revenue Net product revenue Gross net accruals Gross Net Accruals Estimated amount of gross net accruals Investment Type [Axis] Investments [Domain] Short-term Investments [Member] Represents information pertaining to long term investments. Long-term investments [Member] Debt Security Category [Axis] Other than Temporary Impairment, Credit Losses Recognized in Earnings, Categories of Investments [Domain] Obligations of domestic governmental agencies [Member] Debt Securities, Held-to-maturity Amortized cost, as adjusted Debt Securities, Held-to-maturity, Accumulated Unrecognized Gain Gross unrealized holding gains Debt Securities, Held-to-maturity, Accumulated Unrecognized Loss Gross unrealized holding losses Estimated fair value Fair Value Measurement [Table] Short-term Debt, Type [Axis] Short-term Debt, Type [Domain] Convertible Notes Payable [Member] Business Acquisition [Axis] Business Acquisition, Acquiree [Domain] No definition available. Manhattan and Ariston Pharmaceuticals Merger [Member] Line items represent financial concepts included in a table. These concepts are used to disclose reportable information associated with domain members defined in one or many axes to the table. Fair Value Measurement [Line Items] Notes Issued Debt Instrument, Term Debt instrument, term Debt instrument period Det instrument rate Debt Instrument, Convertible, Conversion Price Debt Instrument convertible conversion price Reflects level of percentage of net product cash flow received from the exploitation or commercialization of certain product candidates to repay certain convertible debt. Percentage Of Cash Proceeds From Operation To Repay Convertible Debt Percentage of cash proceeds from operation to repay convertible debt Refers to the number of obligations. Number of Obligations Number of obligations Fair Value, by Balance Sheet Grouping [Table] Fair Value, Hierarchy [Axis] Fair Value Hierarchy and NAV [Domain] Fair Value, Inputs, Level 1 [Member] Fair Value, Inputs, Level 2 [Member] Fair Value, Inputs, Level 3 [Member] Fair Value, Balance Sheet Grouping, Financial Statement Captions [Line Items] 5% Notes Totals Fair Value, Recurring and Nonrecurring [Table] Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] Fair Value, Measurement with Unobservable Inputs Reconciliation, Recurring Basis, Liability Value Balance at end of period Balance at beginning of period Amount of interest recognized during the period, arising from liabilities measured at fair value on a recurring basis using unobservable inputs (level 3). Interest accrued on face value of 5% Notes Change in fair value of Level 3 liabilities Plan Name [Axis] Plan Name [Domain] Represents information pertaining to Amended and Restated 2012 Incentive Plan. Amended and Restated 2012 Incentive Plan [Member] Sale of Stock [Axis] Sale of Stock [Domain] Represents the information pertaining to institutional investor. Institutional Investor [Member] Represents the information pertaining to 2017 At The Market (ATM). 2017 ATM [Member] Represents the information pertaining to 2020 At The Market (ATM). 2020 ATM [Member] Represents the information pertaining to 2021 At The Market (ATM). 2021 ATM [Member] Represents underwritten public offering. Underwritten Public Offering [Member] Over-Allotment Option [Member] Award Type [Axis] Equity Award [Domain] Employees tock options Represents information pertaining to milestone based restricted stock. Milestone Based Restricted Stock [Member] Statistical Measurement [Axis] Statistical Measurement [Domain] Maximum [Member] Preferred stock, shares authorized Preferred stock, par value Preferred stock, par value (in dollars per share) Class of Warrant or Right, Exercise Price of Warrants or Rights Warrant purchase price Class of Warrant or Right, Number of Securities Called by Warrants or Rights Warrants issued Refers to the percent of commission of gross proceeds from the sale of common stock sold paid to agents. Common Stock, Commission Rate Percent of commission rate Gross proceeds from offering Sale of Stock, Price Per Share Share price in offering Sale of Stock, Consideration Received on Transaction Net proceeds from offering Represents the period of underwriter over-allotment option. Period Of Underwriter Overallotment Option Period of underwriter overallotment option Share Price Common share price on date of issuance The cash outflow from payment of underwriting discounts and offering expenses. Payments Of Underwriting Discounts And Offering Expenses Payments of underwriting discounts and offering expenses Share-based Compensation Arrangement by Share-based Payment Award, Number of Additional Shares Authorized Number of shares added to the plan Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Nonvested, Number Number of shares, Outstanding at Ending Balance Number of shares, Outstanding at Beginning Balance Restricted stock outstanding Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Number Equity awards outstanding, end of period Equity awards outstanding, beginning of year Options outstanding Share-based Compensation Arrangement by Share-based Payment Award, Number of Shares Available for Grant Number of additional shares that may be issued Noncash stock compensation expense Recognized stock based compensation expense Employee Service Share-based Compensation, Nonvested Awards, Compensation Cost Not yet Recognized Unrecognized compensation cost Employee Service Share-based Compensation, Nonvested Awards, Compensation Cost Not yet Recognized, Period for Recognition Expected weighted-average period in years of compensation cost to be recognized Share-based Compensation Arrangement by Share-based Payment Award, Non-Option Equity Instruments, Outstanding, Number Warrants Outstanding Reflects the weighted average exercise price of warrants outstanding. Warrant Or Right Outstanding Weighted Average Exercise Price Weighted average exercise price of warrants Number of Shares, Granted Number of shares granted Number of shares, Granted Number of shares, Granted. Share-based Compensation Arrangement by Share-based Payment Award, Options, Forfeitures in Period Number of shares, Expired/Forfeited Number of shares, Exercisable Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Weighted Average Exercise Price Weighted - average exercise price, Outstanding Ending Balance Weighted - average exercise price, Outstanding Beginning Balance Weighted - average exercise price, Granted Weighted - average exercise price, Exercised Weighted - average exercise price, Forfeited Weighted - average exercise price, Exercisable Weighted - average Contractual Term Weighted - average contractual term Weighted - average Contractual Term, Exercisable Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Intrinsic Value Aggregate intrinsic value, Outstanding Share-based Compensation Arrangement by Share-based Payment Award, Options, Exercisable, Intrinsic Value Aggregate Intrinsic Value, Exercisable Equity [Abstract] Minimum [Member] Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions, Expected Volatility Rate, Minimum Volatility, minimum Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions, Expected Volatility Rate, Maximum Volatility, maximum Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions, Expected Term Expected term (in years) Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions, Risk Free Interest Rate, Minimum Risk-free rate, minimum Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions, Risk Free Interest Rate, Maximum Risk-free rate, maximum Equity Incentive Plans Restricted Stock Activity [Table] Line items represent financial concepts included in a table. These concepts are used to disclose reportable information associated with domain members defined in one or many axes to the table. Equity Incentive Plans Restricted Stock Activity [Line Items] Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Vested in Period Number of shares, Vested Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Forfeited in Period Number of shares, Forfeited Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Nonvested, Weighted Average Grant Date Fair Value Weighted-average grant date fair value, Outstanding at Ending Balance Weighted-average grant date fair value, Outstanding at Beginning Balance Weighted Average Grant Date Fair Value, Granted Weighted-average grant date fair value, Granted Weighted Average Grant Date Fair Value, Vested Weighted-average grant date fair value, Vested Weighted Average Grant Date Fair Value, Forfeited Weighted-average grant date fair value, Forfeited Schedule of Long-term Debt Instruments [Table] Debt Instrument [Axis] Debt Instrument, Name [Domain] Represents the information pertaining to term loan. Term Loan [Member] No definition available. Amended Loan Agreement Variable Rate [Axis] Variable Rate [Domain] Prime Rate [Member] Extinguishment of Debt [Axis] Extinguishment of Debt, Type [Domain] Represents the information pertaining to prepayment of debt within 12 months of closing date. Within First twelve Months Of Closing Date [Member] Represents the information pertaining to after 12 months but on or before 24 months of closing date. After Twelve Months But On Or Before Twenty Four Months [Member] Represents the information pertaining to prepayment of debt after 24 months. After Twenty Four Months Of Closing Date [Member] No definition available. Debt Instrument, Loan Tranche [Axis] No definition available. Debt Instrument, Loan Tranche [Domain] Refers to Debt Instrument, Tranche Two. Tranche Two Refers to Debt Instrument, Tranche Three. Tranche Three Refers to Debt Instrument, Tranche Four. Tranche Four Debt Instrument [Line Items] Line of Credit Facility, Maximum Borrowing Capacity Maximum term loan facility Line of Credit, Current Amount of outstanding loan balance Amount drawn. Debt Instrument Draw Amount Amount of draw Number of advances. Number Of Advances Number of advances Amount drawn on first advance. Debt Instrument First Advance drawn Amount drawn on first advance Debt Instrument, Basis Spread on Variable Rate Interest rate ( as a percent) Percentage of prepayment charge. Percentage Of Prepayment Charge Prepayment charge (as a percent) Warrant coverage percentage. Warrant Coverage Percentage Warrant coverage percentage Financing Interest Expense Financing expenses Measurement Input Type [Axis] Measurement Input Type [Domain] Measurement Input, Exercise Price [Member] Measurement Input, Share Price [Member] Measurement Input, Price Volatility [Member] Measurement Input, Risk Free Interest Rate [Member] Measurement Input, Expected Term [Member] Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions, Exercise Price Exercise price Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions, Expected Volatility Rate Volatility Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions, Risk Free Interest Rate Risk-free interest rate Warrants and Rights Outstanding, Term Contractual term (in years) Other Long-term Debt Loan payable No definition available. End Of Term Fee End of term fee No definition available. Long Term Debt Gross Loan payable, gross Unamortized Debt Issuance Expense Less: unamortized debt issuance costs Long-term Debt Loan payable Long term debt excluding principal payments Long Term Debt Excluding Principal Payments Total loan payable Related Party Transaction [Axis] Related Party Transaction [Domain] Office Agreement Member. Office Agreement [Member] No definition available. NC Lease [Member] Adjustments for New Accounting Pronouncements [Axis] Type of Adoption [Domain] ASU 2016-02 Restatement [Axis] Restatement [Domain] Restatement Adjustment It represents percentage of occupancy. Percentage Of Occupancy Area of Land Area of Land Operating Lease Initial Commitment Period Operating Lease Initial Commitment Period Operating lease initial commitment period Average Annual Rental Payments. Average Annual Rental Payments Operating Lease, Expense Rent expense Operating Lease, Liability Operating Lease Liability Total lease liability Remaining lease term of operating lease for lessee. Lessee Operating Lease Remaining Term Of Contract Remaining lease term Number of lease with renewal option. Number Of Leases With Renewal Option Number of lease with renewal option Lessee, Operating Lease, Renewal Term Lease additional term Represents the initial commitment period under the office space lease arrangement. Office Space Lease, Initial Commitment Period Initial commitment period for office lease space Long-term Line of Credit Line of credit Additional Collateral, Aggregate Fair Value Additional collateral pledged Operating Lease, Weighted Average Discount Rate, Percent Weighted-average discount rate for operating leases Operating Lease, Weighted Average Remaining Lease Term Weighted-average remaining operating lease term Operating Lease, Payments, Use Operating Lease, Cost Operating lease cost Lease, Cost Net lease cost Lessee, Operating Lease, Liability, Payments, Due Next Twelve Months 2022 Lessee, Operating Lease, Liability, Payments, Due Year Two 2023 Lessee, Operating Lease, Liability, Payments, Due Year Three 2024 Lessee, Operating Lease, Liability, Payments, Due Year Four 2025 Lessee, Operating Lease, Liability, Payments, Due Year Five 2026 Lessee, Operating Lease, Liability, Payments, Due after Year Five After 2026 Lessee, Operating Lease, Liability, Payments, Due Total lease payments Lessee, Operating Lease, Liability, Undiscounted Excess Amount Less: Interest Deferred tax assets: Net operating loss carryforwards Research and development credit Deferred Tax Assets, Tax Deferred Expense, Compensation and Benefits Noncash compensation Amount, before allocation of valuation allowance, of deferred tax asset attributable to deductible disallowed interest. Deferred Tax Asset, Disallowed Interest Disallowed interest Other Deferred Tax Assets, Gross Deferred tax asset, excluding valuation allowance Deferred Tax Assets, Valuation Allowance Less valuation allowance Valuation allowance Deferred Tax Assets, Net of Valuation Allowance Net deferred tax assets Income (Loss) from Continuing Operations before Income Taxes, Noncontrolling Interest Loss before income taxes, as reported in the consolidated statements of operations Computed "expected" tax benefit Increase (decrease) in income taxes resulting from: Expected benefit from state and local taxes Effective Income Tax Rate Reconciliation, Tax Credit, Research, Amount Research and development credits Effective Income Tax Rate Reconciliation, Other Adjustments, Amount Other Stock awards Enactment of federal tax reform Change in the balance of the valuation allowance for deferred tax assets Income taxes Income Tax Expense (Benefit) Operating Loss Carryforwards Research and Development Carryforward Amount of business interest expense carryforward. Business Interest Expense Carryforward Effective Income Tax Rate Reconciliation, at Federal Statutory Income Tax Rate, Percent Unrecognized Tax Benefits, Income Tax Penalties and Interest Accrued Accrual for interest and penalties related to uncertain tax positions Legal Entity [Axis] Entity [Domain] Represents the information pertaining to JBET Agreement. JBET Agreement [Member] No definition available. TG-1101 [Member] No definition available. TG-1701 [Member] No definition available. TG-1801 [Member] Represents information pertaining to TGR-1202 (Ublituximab). TGR-1202 [Member] No definition available. Agreement Type [Axis] No definition available. Agreement Type [Domain] No definition available. Collaboration Agreement [Member] Represents amount received for sub license. Upfront Fee Received From Sub License Upfront fee Represents the term after the first commercial sale. Term After First Commercial Sale Term after first commercial sale Deferred Revenue Current portion of deferred revenue Deferred Revenue, Current Reflects potential milestone payments to be received upon achievement of pre-specified milestone. Additional Amount Receivable on Achievement of Pre-specified Milestones Additional payments on achievement of certain milestones Manufacturing Costs Manufacturing expense The amount of milestone payment made in accordance with license agreements. License And Collaboration Agreements, Milestone Payment Made Milestone payment made Number of oncology indications. Number of Oncology Indications Number of oncology indications Number of non oncology indications. Number of Non Oncology Indications Number of non oncology indications Royalty Expense The amount of expenses incurred under the license and collaboration agreement. License And Collaboration Agreement, Expenses Incurred Expenses incurred Contractual obligations [Axis] No definition available. Contractual Obligations [Domain] No definition available. Operating Leases [Member] Long-term debt [Member] Contractual Obligation, Due in Next Fiscal Year Payment due by period, Contractual obligations, Less than 1 year Contractual Obligation, Due in Second and Third Year Payment due by period, Contractual obligations, 1-3 years Contractual Obligation, Due in Fourth and Fifth Year Payment due by period, Contractual obligations, 3-5 years Contractual Obligation, Due after Fifth Year Payment due by period, Contractual obligations, More than 5 years Contractual Obligation Contractual obligation Payment due by period, Contractual obligations, Total