Note 9 - Income Taxes - Schedule of Deferred Tax Assets and Liabilities (Details) - USD ($) $ in Thousands	Dec. 31, 2024	Dec. 31, 2023
Net operating loss carryforwards	$ 294,046	$ 316,962
Research and development credit	50,693	45,806
Noncash compensation	12,267	12,275
Disallowed interest	0	3,328
Capitalized R&D Expenses	49,681	36,613
Other	7,927	3,333
Deferred tax asset, excluding valuation allowance	414,614	418,317
Less valuation allowance	(414,614)	(418,317)
Net deferred tax assets	$ 0	$ 0