Note 9 - Income Taxes (Tables)

12 Months Ended

Dec. 31, 2024

Notes Tables

Schedule of Deferred Tax Assets and Liabilities [Table Text Block]

(in thousands)	2024			2023
Deferred tax assets:
Net operating loss carryforwards	$294,046			$316,962
Research and development credit	50,693			45,806
Noncash compensation	12,267			12,275
Disallowed interest	—			3,328
Capitalized R&D Expenses	49,681			36,613
Other	7,927			3,333
Deferred tax asset, excluding valuation allowance		414,614			418,317
Less valuation allowance	(414,614		)	(418,317		)
Net deferred tax assets	$	—		$	—

Schedule of Effective Income Tax Rate Reconciliation [Table Text Block]

	For the year ended December 31,
(in thousands)	2024			2023			2022
Income (loss) before income taxes, as reported in the consolidated statements of operations	$	25,594		$	13,062		$	(223,812	)
Computed “expected” tax benefit	$	5,375		$	2,743		$	(47,000	)
Increase (decrease) in income taxes resulting from:
State and local taxes		780			(700	)		(8,457	)
Research and development credits		(4,637	)		(3,402	)		(6,366	)
Officer Compensation Limitation		2,164			(740	)		20,580
Provision-to-return		11,733			(9,235	)		60
Prior period state tax benefit		(3,508	)		—			—
Other		646			245			358
Stock options		(1,602	)		(10,616	)		7,908
Change in state tax rates		(4,970	)		4,141			—
Change in the balance of the valuation allowance for deferred tax assets		(3,770	)		17,954			32,917
	$	2,211		$	390		$	—