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  <xsd:element abstract="true" id="tgtx_InternationalMember" name="InternationalMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element id="tgtx_InvestmentPurchasedBalancePricePerShare" name="InvestmentPurchasedBalancePricePerShare" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:perShareItemType" xbrli:periodType="instant"/>
  <xsd:element id="tgtx_InvestmentPurchasedBalanceShares" name="InvestmentPurchasedBalanceShares" nillable="true" substitutionGroup="xbrli:item" type="xbrli:sharesItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="tgtx_LFBLicenseAgreementMember" name="LFBLicenseAgreementMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element id="tgtx_LeaseholdInterest" name="LeaseholdInterest" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="instant"/>
  <xsd:element id="tgtx_LeasesPolicyTextBlock" name="LeasesPolicyTextBlock" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:textBlockItemType" xbrli:periodType="duration"/>
  <xsd:element id="tgtx_LesseeOperatingLeaseLiabilityToBePaidYearFourAndFive" name="LesseeOperatingLeaseLiabilityToBePaidYearFourAndFive" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="instant"/>
  <xsd:element id="tgtx_LesseeOperatingLeaseLiabilityToBePaidYearTwoAndThree" name="LesseeOperatingLeaseLiabilityToBePaidYearTwoAndThree" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="instant"/>
  <xsd:element id="tgtx_LicenseAgreementAdditionalMilestonePayments" name="LicenseAgreementAdditionalMilestonePayments" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="instant"/>
  <xsd:element id="tgtx_LicenseAgreementAmountPaidUpfront" name="LicenseAgreementAmountPaidUpfront" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="duration"/>
  <xsd:element id="tgtx_LicenseAgreementAmountPaidUpfrontCash" name="LicenseAgreementAmountPaidUpfrontCash" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="instant"/>
  <xsd:element id="tgtx_LicenseAgreementAmountPaidUpfrontEquityInvestment" name="LicenseAgreementAmountPaidUpfrontEquityInvestment" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="instant"/>
  <xsd:element id="tgtx_LicenseAgreementDeferredPayment" name="LicenseAgreementDeferredPayment" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="instant"/>
  <xsd:element id="tgtx_LicenseAgreementDisclosureTextBlock" name="LicenseAgreementDisclosureTextBlock" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:textBlockItemType" xbrli:periodType="duration"/>
  <xsd:element id="tgtx_LicenseAndCollaborationAgreementExpensesIncurred" name="LicenseAndCollaborationAgreementExpensesIncurred" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration"/>
  <xsd:element id="tgtx_LicenseAndCollaborationAgreementsOnetimeNonrefundablePayment" name="LicenseAndCollaborationAgreementsOnetimeNonrefundablePayment" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration"/>
  <xsd:element id="tgtx_LicenseRevenue" name="LicenseRevenue" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="tgtx_LicenseRevenueMember" name="LicenseRevenueMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element id="tgtx_LiquidityAndCapitalResourcesPolicyPolicyTextBlock" name="LiquidityAndCapitalResourcesPolicyPolicyTextBlock" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:textBlockItemType" xbrli:periodType="duration"/>
  <xsd:element id="tgtx_LongTermDebtAccretedLiabilityOfFinalPaymentFee" name="LongTermDebtAccretedLiabilityOfFinalPaymentFee" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="instant"/>
  <xsd:element abstract="true" id="tgtx_LongTermInvestmentsMember" name="LongTermInvestmentsMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element id="tgtx_LongtermDebtBeforeRepayments" name="LongtermDebtBeforeRepayments" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="instant"/>
  <xsd:element abstract="true" id="tgtx_ManhattanAndAristonPharmaceuticalsMergerMember" name="ManhattanAndAristonPharmaceuticalsMergerMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="tgtx_MilestoneBasedRestrictedStockMember" name="MilestoneBasedRestrictedStockMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element id="tgtx_MilestonePayments" name="MilestonePayments" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="duration"/>
  <xsd:element id="tgtx_NonCashCompensationResearchAndDevelopmentExpenses" name="NonCashCompensationResearchAndDevelopmentExpenses" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration"/>
  <xsd:element id="tgtx_NonCashCompensationSellingGeneralAndAdministrativeExpenses" name="NonCashCompensationSellingGeneralAndAdministrativeExpenses" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="tgtx_NoteToFinancialStatementDetailsTextual" name="NoteToFinancialStatementDetailsTextual" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="tgtx_NotesToFinancialStatements" name="NotesToFinancialStatements" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="tgtx_NotesToFinancialStatementsAbstract" name="NotesToFinancialStatementsAbstract" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="tgtx_OfficeAgreementMember" name="OfficeAgreementMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="tgtx_OfficeAgreementWithFortressBiotechMember" name="OfficeAgreementWithFortressBiotechMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="tgtx_OtherRevenueMember" name="OtherRevenueMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element id="tgtx_PaidinkindInterestRate" name="PaidinkindInterestRate" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:percentItemType" xbrli:periodType="instant"/>
  <xsd:element id="tgtx_PercentageOfOccupancy" name="PercentageOfOccupancy" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:percentItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="tgtx_PrecisionLicenseAgreementMember" name="PrecisionLicenseAgreementMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="tgtx_PrecisionMember" name="PrecisionMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element id="tgtx_PrepaidResearchAndDevelopment" name="PrepaidResearchAndDevelopment" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="instant"/>
  <xsd:element id="tgtx_ProceedsFromIssuanceOfCommonStockNet" name="ProceedsFromIssuanceOfCommonStockNet" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration"/>
  <xsd:element id="tgtx_ProceedsFromSalesReturns" name="ProceedsFromSalesReturns" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration"/>
  <xsd:element id="tgtx_ProductSalesNetRelatedToPerformanceObligations" name="ProductSalesNetRelatedToPerformanceObligations" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="instant"/>
  <xsd:element id="tgtx_QualifiedSalesbasedMilestoneRevenue" name="QualifiedSalesbasedMilestoneRevenue" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="tgtx_RhizenMember" name="RhizenMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="tgtx_RightsToPurchaseSeriesAJuniorParticipatingPreferredStockMember" name="RightsToPurchaseSeriesAJuniorParticipatingPreferredStockMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element id="tgtx_RoyaltyPercentageOnNetProductSales" name="RoyaltyPercentageOnNetProductSales" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:percentItemType" xbrli:periodType="duration"/>
  <xsd:element id="tgtx_ScheduleOfBalanceSheetClassificationOfOperatingLeaseTableTextBlock" name="ScheduleOfBalanceSheetClassificationOfOperatingLeaseTableTextBlock" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:textBlockItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="tgtx_SeriesAJuniorParticipatingPreferredStockMember" name="SeriesAJuniorParticipatingPreferredStockMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element id="tgtx_StockIssuedDuringPeriodValueRestrictedStockAwardCommonStockForfeited" name="StockIssuedDuringPeriodValueRestrictedStockAwardCommonStockForfeited" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="tgtx_StockbasedCompensationExpenseCapitalizedIntoInventoryMember" name="StockbasedCompensationExpenseCapitalizedIntoInventoryMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="tgtx_SublicenseAgreementWithIldongPharmaceuticalCoMember" name="SublicenseAgreementWithIldongPharmaceuticalCoMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="tgtx_TermLoanAdvancesMember" name="TermLoanAdvancesMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="tgtx_TermLoanMember" name="TermLoanMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="tgtx_Tg1501Member" name="Tg1501Member" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="tgtx_Tg1701Member" name="Tg1701Member" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="tgtx_Tg1801Member" name="Tg1801Member" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="tgtx_The2012IncentivePlanMember" name="The2012IncentivePlanMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="tgtx_The2020AtmMember" name="The2020AtmMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="tgtx_The2021AtmMember" name="The2021AtmMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="tgtx_The2022AtmMember" name="The2022AtmMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="tgtx_The2022IncentivePlanMember" name="The2022IncentivePlanMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="tgtx_TheFirstAmendmentTermLoanMember" name="TheFirstAmendmentTermLoanMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="tgtx_TheFirstAmendmentWarrantMember" name="TheFirstAmendmentWarrantMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="tgtx_TheNewJerseyLeaseMember" name="TheNewJerseyLeaseMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="tgtx_TheNorthCarolinaLeaseMember" name="TheNorthCarolinaLeaseMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="tgtx_TheUmbralisibLicenseMember" name="TheUmbralisibLicenseMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="tgtx_UkoniqMember" name="UkoniqMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="tgtx_UnvestedRestrictedStockMember" name="UnvestedRestrictedStockMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element id="tgtx_UpfrontFeeReceivedFromSubLicense" name="UpfrontFeeReceivedFromSubLicense" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="duration"/>
  <xsd:element id="tgtx_WarrantCoveragePercentage" name="WarrantCoveragePercentage" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:percentItemType" xbrli:periodType="duration"/>
  <xsd:element id="tgtx_WarrantsIssuedWithDebtFinancingNoncash" name="WarrantsIssuedWithDebtFinancingNoncash" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="tgtx_WarrantsToPurchaseCommonStockAmendedLoanAgreementMember" name="WarrantsToPurchaseCommonStockAmendedLoanAgreementMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="tgtx_WarrantsToPurchaseCommonStockFirstAmendmentLoanAgreementMember" name="WarrantsToPurchaseCommonStockFirstAmendmentLoanAgreementMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="tgtx_WarrantsToPurchaseCommonStockFirstAmendmentMember" name="WarrantsToPurchaseCommonStockFirstAmendmentMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="tgtx_WarrantsToPurchaseCommonStockLoanAgreementMember" name="WarrantsToPurchaseCommonStockLoanAgreementMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="tgtx_WorldwideMember" name="WorldwideMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="tgtx_statement-statement-note-1-organization-and-summary-of-significant-accounting-policies-schedule-of-earnings-per-share-details" name="statement-statement-note-1-organization-and-summary-of-significant-accounting-policies-schedule-of-earnings-per-share-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="tgtx_statement-statement-note-1-organization-and-summary-of-significant-accounting-policies-schedule-of-potentially-dilutive-securities-details" name="statement-statement-note-1-organization-and-summary-of-significant-accounting-policies-schedule-of-potentially-dilutive-securities-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="tgtx_statement-statement-note-1-organization-and-summary-of-significant-accounting-policies-tables" name="statement-statement-note-1-organization-and-summary-of-significant-accounting-policies-tables" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="tgtx_statement-statement-note-12-commitments-and-contingencies-contractual-obligation-fiscal-year-maturity-details" name="statement-statement-note-12-commitments-and-contingencies-contractual-obligation-fiscal-year-maturity-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="tgtx_statement-statement-note-12-commitments-and-contingencies-tables" name="statement-statement-note-12-commitments-and-contingencies-tables" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="tgtx_statement-statement-note-2-revenue-recognition-disaggregation-of-revenue-by-product-and-geography-details" name="statement-statement-note-2-revenue-recognition-disaggregation-of-revenue-by-product-and-geography-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="tgtx_statement-statement-note-2-revenue-recognition-disaggregation-of-revenue-details" name="statement-statement-note-2-revenue-recognition-disaggregation-of-revenue-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="tgtx_statement-statement-note-2-revenue-tables" name="statement-statement-note-2-revenue-tables" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="tgtx_statement-statement-note-3-investment-securities-schedule-of-investment-securities-details" name="statement-statement-note-3-investment-securities-schedule-of-investment-securities-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="tgtx_statement-statement-note-3-investment-securities-schedule-of-investment-securities-details-parentheticals" name="statement-statement-note-3-investment-securities-schedule-of-investment-securities-details-parentheticals" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="tgtx_statement-statement-note-3-investment-securities-tables" name="statement-statement-note-3-investment-securities-tables" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="tgtx_statement-statement-note-4-inventory-schedule-of-inventory-details" name="statement-statement-note-4-inventory-schedule-of-inventory-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="tgtx_statement-statement-note-4-inventory-tables" name="statement-statement-note-4-inventory-tables" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="tgtx_statement-statement-note-5-fair-value-measurements-schedule-of-change-in-level-three-fair-value-details" name="statement-statement-note-5-fair-value-measurements-schedule-of-change-in-level-three-fair-value-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="tgtx_statement-statement-note-5-fair-value-measurements-schedule-of-change-in-level-three-fair-value-details-parentheticals" name="statement-statement-note-5-fair-value-measurements-schedule-of-change-in-level-three-fair-value-details-parentheticals" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="tgtx_statement-statement-note-5-fair-value-measurements-schedule-of-fair-value-measurements-details" name="statement-statement-note-5-fair-value-measurements-schedule-of-fair-value-measurements-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="tgtx_statement-statement-note-5-fair-value-measurements-tables" name="statement-statement-note-5-fair-value-measurements-tables" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="tgtx_statement-statement-note-6-stockholders-equity-schedule-of-fair-value-assumptions-details" name="statement-statement-note-6-stockholders-equity-schedule-of-fair-value-assumptions-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="tgtx_statement-statement-note-6-stockholders-equity-schedule-of-nonvested-restricted-stock-activity-details" name="statement-statement-note-6-stockholders-equity-schedule-of-nonvested-restricted-stock-activity-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="tgtx_statement-statement-note-6-stockholders-equity-summary-of-stock-option-activity-details" name="statement-statement-note-6-stockholders-equity-summary-of-stock-option-activity-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="tgtx_statement-statement-note-6-stockholders-equity-tables" name="statement-statement-note-6-stockholders-equity-tables" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="tgtx_statement-statement-note-7-loan-payable-schedule-of-key-assumptions-details" name="statement-statement-note-7-loan-payable-schedule-of-key-assumptions-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="tgtx_statement-statement-note-7-loan-payable-schedule-of-loan-payble-details" name="statement-statement-note-7-loan-payable-schedule-of-loan-payble-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="tgtx_statement-statement-note-7-loan-payable-tables" name="statement-statement-note-7-loan-payable-tables" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="tgtx_statement-statement-note-8-leases-schedule-of-classification-of-lease-liabilities-details" name="statement-statement-note-8-leases-schedule-of-classification-of-lease-liabilities-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="tgtx_statement-statement-note-8-leases-schedule-of-lease-liability-maturity-details" name="statement-statement-note-8-leases-schedule-of-lease-liability-maturity-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="tgtx_statement-statement-note-8-leases-tables" name="statement-statement-note-8-leases-tables" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="tgtx_statement-statement-note-9-income-taxes-schedule-of-deferred-tax-assets-and-liabilities-details" name="statement-statement-note-9-income-taxes-schedule-of-deferred-tax-assets-and-liabilities-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="tgtx_statement-statement-note-9-income-taxes-schedule-of-effective-income-tax-rate-reconciliation-details" name="statement-statement-note-9-income-taxes-schedule-of-effective-income-tax-rate-reconciliation-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="tgtx_statement-statement-note-9-income-taxes-tables" name="statement-statement-note-9-income-taxes-tables" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="tgtx_statement-statement-significant-accounting-policies-policies" name="statement-statement-significant-accounting-policies-policies" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
</xsd:schema>
