X0201 4 2004-01-28 0 0001001316 MANHATTAN PHARMACEUTICALS INC MHTT 0001167450 ROSSETTOS NICHOLAS J 787 SEVENTH AVENUE, 48TH FLOOR NEW YORK NY 10019 0 1 0 0 Chief Financial Officer Stock Options 20.94 2010-04-12 Common Stock 10000 10000 D Stock Options 4.375 2011-02-20 Common Stock 10000 10000 D Stock Options 1.25 2012-02-19 Common Stock 10000 10000 D Stock Options 1.25 2012-02-19 Common Stock 10000 10000 D Stock Options 1 2002-03-28 2012-03-28 Common Stock 25000 25000 D Stock Options .4 2013-02-24 Common Stock 292030 292030 D Stock Options 1.25 2012-02-19 Common Stock 10000 10000 D Stock Option 1.65 2004-01-28 4 A 0 150000 0 A 2014-01-28 Common Stock 150000 150000 D (Right to buy) Currently exercisable. 2,500 shares each vest on 2/20/01, 2/20/02, 2/20/03 and 2/20/04. 2,500 shares each vest on 2/19/02, 2/19/03, 2/19/04 and 2/19/05. 146,015 shares are currently vested; 146,015 shares vest on 2/24/05. Option vests on the earlier of FDA approval or Catarex or 2/19/07. 50,000 shares each vest on 1/28/04, 1/28/05 and 1/28/06. /s/ Nicholas J. Rossettos 2004-02-03