Condensed Consolidated Statements of Operations - USD ($)	3 Months Ended
Mar. 31, 2016	Mar. 31, 2015
License revenue	$ 38,095	$ 38,095
Research and development:
Noncash compensation	386,925	1,337,908
Other research and development	11,230,415	8,279,431
Total research and development	11,617,340	9,617,339
General and administrative:
Noncash compensation	1,312,040	4,019,120
Other general and administrative	1,100,871	1,004,487
Total general and administrative	2,412,911	5,023,607
Total costs and expenses	14,030,251	14,640,946
Operating loss	(13,992,156)	(14,602,851)
Other (income) expense:
Interest income	(84,862)	(22,132)
Interest expense	242,405	237,657
Change in fair value of notes payable	(301,037)	(240,641)
Total other income	(143,494)	(25,116)
Net loss	$ (13,848,662)	$ (14,577,735)
Basic and diluted net loss per common share	$ (0.28)	$ (0.35)
Weighted average shares used in computing basic and diluted net loss per common share	48,908,278	41,088,752

The change in the fair value of non current notes payable recognized during the period.

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The aggregate compensation expense related to the grants of stock options and restricted stock that is attributable to general and administrative expenses during the reporting period.

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The aggregate compensation expense related to the grants of stock options and restricted stock that is attributable to research and development expenses during the reporting period.

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The amount of net income or loss for the period per each share in instances when basic and diluted earnings per share are the same amount and reported as a single line item on the face of the financial statements. Basic earnings per share is the amount of net income or loss for the period per each share of common stock or unit outstanding during the reporting period. Diluted earnings per share includes the amount of net income or loss for the period available to each share of common stock or common unit outstanding during the reporting period and to each share or unit that would have been outstanding assuming the issuance of common shares or units for all dilutive potential common shares or units outstanding during the reporting period.

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The aggregate total of expenses of managing and administering the affairs of an entity, including affiliates of the reporting entity, which are not directly or indirectly associated with the manufacture, sale or creation of a product or product line.

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Amount of the cost of borrowed funds accounted for as interest expense.

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Revenue earned during the period relating to consideration received from another party for the right to use, but not own, certain of the entity's intangible assets. Licensing arrangements include, but are not limited to, rights to use a patent, copyright, technology, manufacturing process, software or trademark. Licensing fees are generally, but not always, fixed as to amount and not dependent upon the revenue generated by the licensing party. An entity may receive licensing fees for licenses that also generate royalty payments to the entity.

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Generally recurring costs associated with normal operations except for the portion of these expenses which can be clearly related to production and included in cost of sales or services. Includes selling, general and administrative expense.

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The net result for the period of deducting operating expenses from operating revenues.

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The consolidated profit or loss for the period, net of income taxes, including the portion attributable to the noncontrolling interest.

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The aggregate costs incurred (1) in a planned search or critical investigation aimed at discovery of new knowledge with the hope that such knowledge will be useful in developing a new product or service, a new process or technique, or in bringing about a significant improvement to an existing product or process; or (2) to translate research findings or other knowledge into a plan or design for a new product or process or for a significant improvement to an existing product or process whether intended for sale or the entity's use, during the reporting period charged to research and development projects, including the costs of developing computer software up to the point in time of achieving technological feasibility, and costs allocated in accounting for a business combination to in-process projects deemed to have no alternative future use.

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Average number of shares or units issued and outstanding that are used in calculating basic and diluted earnings per share (EPS).

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