Document And Entity Information [Abstract] Document Information [Table] Legal Entity [Axis] Document Type Amendment Flag Document Period End Date Document Fiscal Year Focus Document Fiscal Period Focus Entity Registrant Name Entity Central Index Key Current Fiscal Year End Date Entity Well-known Seasoned Issuer Entity Voluntary Filers Entity Current Reporting Status Entity Filer Category Entity Public Float Trading Symbol Entity Common Stock, Shares Outstanding Investments, Debt and Equity Securities [Abstract] Investments in Debt and Marketable Equity Securities (and Certain Trading Assets) Disclosure [Text Block] Fair Value Disclosures [Abstract] Fair Value Disclosures [Text Block] Fair Value Disclosures [Text Block] Stockholders' Equity Note [Abstract] Shareholders Equity and Share-based Payments [Text Block] Debt Disclosure [Abstract] License Agreement [Abstract] License Agreement [Abstract] License Agreement Disclosure [Text Block] License Agreement Disclosure [Text Block] The entire disclosure for research, development, and License Agreement activities, including contracts and arrangements to be performed for others and with federal government. Related Party Transactions [Abstract] Related Party Transactions Disclosure [Text Block] Related Party Transactions Disclosure [Text Block] Accounting Policies [Abstract] Business Description [Policy Text Block] Business Description [Policy Text Block] Reflects the description of business of the entity. Liquidity Disclosure1 [Policy Text Block] Liquidity Disclosure [Policy Text Block] Disclosure of accounting policy for reporting when there is a substantial doubt about an entity's ability to continue as a going concern for a reasonable period of time (generally a year from the balance sheet date). Disclose: (a) pertinent conditions and events giving rise to the assessment of substantial doubt about the entity's ability to continue as a going concern for a reasonable period of time, (b) the possible effects of such conditions and events, (c) management's evaluation of the significance of those conditions and events and any mitigating factors, (d) possible discontinuance of operations, (e) management's plans (including relevant prospective financial information), and (f) information about the recoverability or classification of recorded asset amounts or the amounts or classification of liabilities. If management's plans alleviate the substantial doubt about the entity's ability to continue as a going concern, disclosure of the principal conditions and events that initially raised the substantial doubt about the entity's ability to continue as a going concern would be expected to be considered. Disclose whether operations for the current or prior years generated sufficient cash to cover current obligations, whether waivers were obtained from creditors relating to the company's default under the provisions of debt agreements and possible effects of such conditions and events, such as: whether there is a possible need to obtain additional financing (debt or equity) or to liquidate certain holdings to offset future cash flow deficiencies. Disclose appropriate parent company information when parent is dependent upon remittances from subsidiaries to satisfy its obligations. New Accounting Pronouncements, Policy [Policy Text Block] Use of Estimates, Policy [Policy Text Block] Cash and Cash Equivalents, Policy [Policy Text Block] Cash and Cash Equivalents, Policy [Policy Text Block] Cash and Cash Equivalents, Restricted Cash and Cash Equivalents, Policy [Policy Text Block] Marketable Securities, Policy [Policy Text Block] Concentration Risk, Credit Risk, Policy [Policy Text Block] Revenue Recognition, Policy [Policy Text Block] Revenue Recognition, Policy [Policy Text Block] Research and Development Expense, Policy [Policy Text Block] Research and Development Expense, Policy [Policy Text Block] Cash and Cash Equivalents [Abstract] Schedule of Cash and Cash Equivalents [Table Text Block] Held-to-maturity Securities [Table Text Block] Statement Of Financial Position [Abstract] Statement [Table] Scenario [Axis] Scenario, Unspecified [Domain] Statement [Line Items] Assets [Abstract] Assets Assets, Current [Abstract] Current assets: Cash and Cash Equivalents, at Carrying Value, Total Cash and cash equivalents Total Cash and cash equivalents at beginning of year CASH AND CASH EQUIVALENTS AT END OF YEAR Short-term Investments, Total Short-term investment securities Interest Receivable, Current Interest receivable Prepaid Research And Development Prepaid research and development Sum of the amounts paid in advance for capitalized costs that will be expensed with Research and development. Other Assets, Current Other current assets Assets, Current, Total Total current assets Restricted Cash and Cash Equivalents, Noncurrent Restricted cash Long-term Investments, Total Long-term investment securities Property, Plant and Equipment, Net, Total Property, plant and equipment, net Goodwill Goodwill Other Assets, Noncurrent Other assets Liabilities and Equity [Abstract] Liabilities and stockholders’ equity Liabilities, Current [Abstract] Current liabilities: Accounts Payable and Accrued Liabilities, Current, Total Accounts payable and accrued expenses Deferred Compensation Liability, Current, Total Accrued compensation Deferred Revenue, Current Current portion of deferred revenue Notes Payable, Current, Total Notes payable Notes payable, Current portion, net Liabilities, Current, Total Total current liabilities Deferred Revenue, Noncurrent Deferred revenue, net of current portion Liabilities, Total Total liabilities Commitments and Contingencies Commitments and contingencies Stockholders Equity Attributable To Parent [Abstract] Stockholders’ equity: Preferred Stock, Value, Issued Preferred stock, $0.001 par value per share (10,000,000 shares authorized, none issued and outstanding as of December 31, 2015 and 2014) Common Stock, Value, Issued Common stock, $0.001 par value per share (150,000,000 shares authorized, 54,095,110 and 44,974,248 shares issued, 54,053,801 and 44,932,939 shares outstanding at December 31, 2015 and 2014, respectively) Contingently Issuable Shares Contingently issuable shares The shares issuable for merger of companies Additional Paid in Capital, Total Additional paid-in capital Treasury Stock, Value Treasury stock, at cost, 41,309 shares at December 31, 2015 and 2014 Retained Earnings (Accumulated Deficit) Accumulated deficit Accumulated deficit Stockholders Equity, Including Portion Attributable to Noncontrolling Interest, Total Total stockholders’ equity Balance Balance Liabilities and Equity, Total Total liabilities and stockholders’ equity Fair Value, Liabilities Measured On Recurring and Nonrecurring Basis [Table Text Block] Fair Value, Liabilities Measured on Recurring and Nonrecurring Basis [Table Text Block] Fair Value, Liabilities Measured On Recurring Basis, Unobservable Input Reconciliation [Table Text Block] Change In Level Three Fair Value During Period [Table Text Block] Schedule of Share-based Compensation, Stock Options, Activity [Table Text Block] Schedule of Nonvested Restricted Stock Units Activity [Table Text Block] Schedule Of Warrants Activity [Table Text Block] Tabular disclosure for warrants activity. Schedule Of Share Based Compensation Expense [Table Text Block] Tabular disclosure of Share based compensation expense during the period. Schedule Of Debt [Table Text Block] Schedule of Debt [Table Text Block] Significant Accounting Policies [Table] Schedule reflecting the organisation and summary of significant accounting policies. Business Acquisition [Axis] Business Acquisition, Acquiree [Domain] Equity Components [Axis] Equity Component [Domain] Class of Stock [Axis] Class of Stock [Domain] Title of Individual [Axis] Relationship to Entity [Domain] Related Party [Axis] Related Party [Domain] Vesting Period [Axis] Represents vesting Period Vesting Period [Domain] Represents vesting Period. Market Capitalization Target [Axis] Represents Market capitalization target. Market Capitalization Target [Domain] Represents Market capitalization target Immaterial Error [Axis] Represents immaterial error. Immaterial Error [Domain] Subsequent Event Type [Axis] Subsequent Event Type [Domain] Range [Axis] Range [Domain] Minimum [Member] Significant Accounting Policies [Line Items] Line items represent financial concepts included in a table. These concepts are used to disclose reportable information associated with domain members defined in one or many axes to the table. Antidilutive Securities Excluded From Computation Of Earnings Per Share, Amount Antidilutive Securities Excluded from Computation of Earnings Per Share, Amount Period Anticipated Sufficient To Fund Operating Cash Flow Disclosure about period anticipated sufficient to fund operating cash flow. Cash, Cash Equivalents, and Short-term Investments, Total Schedule of Cash and Cash Equivalents [Table] Entity [Domain] Cash and Cash Equivalents [Line Items] Money Market Funds, at Carrying Value Money market funds Cash Checking and bank deposits Schedule of Held-to-maturity Securities [Table] Major Types of Debt and Equity Securities [Axis] Major Types of Debt and Equity Securities [Domain] US Government Agencies Debt Securities [Member] Obligations of domestic governmental agencies [Member] Schedule of Fair Value of Separate Accounts by Major Category of Investment [Axis] Schedule of Fair Value of Separate Accounts by Major Category of Investment, Category [Domain] Short-term Investments [Member] Other Long-term Investments [Member] Schedule of Held-to-maturity Securities [Line Items] Held-to-maturity Securities Amortized cost, as adjusted Held-to-maturity Securities, Unrecognized Holding Gain Gross unrealized holding gains Held-to-maturity Securities, Unrecognized Holding Loss Gross unrealized holding losses Held-to-maturity Securities, Fair Value Estimated fair value Fair Value, by Balance Sheet Grouping [Table] Fair Value, Hierarchy [Axis] Fair Value Hierarchy [Domain] Fair Value, Inputs, Level 1 [Member] Fair Value, Inputs, Level 2 [Member] Fair Value, Inputs, Level 3 [Member] Short-term Debt, Type [Axis] Short-term Debt, Type [Domain] Fair Value, Balance Sheet Grouping, Financial Statement Captions [Line Items] Financial and Nonfinancial Liabilities, Fair Value Disclosure, Total 5% Notes Notes Payable, Fair Value Disclosure Totals Fair Value, Measurement Changes In Level 3 Instruments [Table] Fair value disclosures related to financial assets (as defined) and financial liabilities (as defined) contained in the entity's balance sheet. Disclosures contained in this table include the changes in level 3 instruments. Fair Value, Measurement Changes In Level 3 Instruments [Line Items] Line items represent financial concepts included in a table. These concepts are used to disclose reportable information associated with domain members defined in one or many axes to the table. Fair Value, Measurement with Unobservable Inputs Reconciliation, Recurring Basis, Liability Value, Beginning Balance Balance at January Balance at December Fair Value Measurement With Unobservable Inputs Reconciliation Recurring Basis Liability Interest Accrued Included In Earnings Interest accrued on face value of 5% Notes Amount of interest recognized during the period, arising from liabilities measured at fair value on a recurring basis using unobservable inputs (level 3). Fair Value, Measurement with Unobservable Inputs Reconciliation, Recurring Basis, Liability, Settlements Conversion of 5% Notes Fair Value, Measurement with Unobservable Inputs Reconciliation, Recurring Basis, Liability, Period Increase (Decrease) Change in fair value of Level 3 liabilities Fair Value Measurement [Table] Type Of Transaction [Axis] Type Of Transaction [Domain] Manhattan and Ariston Pharmaceuticals Merger [Member] Other Operating Cost And Expense [Axis] Other Operating Cost And Expense [Domain] Notes Issued Notes Issued Debt Instrument, Convertible, Conversion Price Debt Instrument, Convertible, Conversion Price Percentage Of Cash Proceeds From Operation To Repay Convertible Debt Percentage Of Cash Proceeds From Operation To Repay Convertible Debt Reflects level of percentage of net product cash flow received from the exploitation or commercialization of certain product candidates to repay certain convertible debt. Long-term Debt, Gross Long-term Debt, Gross Debt Instrument, Term Statement Of Stockholders Equity [Abstract] Equity Incentive Plans Stock Option Activity [Table] Option Indexed to Issuer's Equity [Axis] Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Number, Beginning Balance Number of shares, Outstanding Beginning Balance Number of shares, Outstanding Ending Balance Restricted Stock, Outstanding, Number, Ending Balance Share-based Compensation Arrangement by Share-based Payment Award, Options, Grants in Period, Net of Forfeitures, Total Number of shares, Granted Share-Based Compensation Arrangement By Share-Based Payment Award, Options, Exercises In Period Number of shares, Exercised Share-Based Compensation Arrangement By Share-Based Payment Award, Options, Forfeitures In Period Number of shares, Forfeited Share-Based Compensation Arrangement By Share-Based Payment Award, Options, Expirations In Period Number of shares, Expired Share-Based Compensation Arrangement By Share-Based Payment Award, Options, Exercisable, Number Number of shares, Exercisable at December 31, 2015 Share-Based Compensation Arrangement By Share-Based Payment Award, Options, Outstanding, Weighted Average Exercise Price, Beginning Balance Weighted - average exercise price, Outstanding Beginning Balance Weighted - average exercise price, Outstanding Ending Balance Share-based Compensation Arrangements by Share-based Payment Award, Options, Grants in Period, Weighted Average Exercise Price Weighted - average exercise price, Granted Share-based Compensation Arrangements by Share-based Payment Award, Options, Exercises in Period, Weighted Average Exercise Price Weighted - average exercise price, Exercised Share-based Compensation Arrangements by Share-based Payment Award, Options, Forfeitures in Period, Weighted Average Exercise Price Weighted - average exercise price, Forfeited Share-based Compensation Arrangements by Share-based Payment Award, Options, Expirations in Period, Weighted Average Exercise Price Weighted - average exercise price, Expired Share-Based Compensation Arrangement By Share-Based Payment Award, Options, Exercisable, Weighted Average Exercise Price Weighted - average exercise price, Exercisable at December 31, 2015 Share-Based Compensation Arrangement By Share-Based Payment Award, Options, Outstanding, Weighted Average Remaining Contractual Term Weighted - average Contractual Term (in years) Share-Based Compensation Arrangement By Share-Based Payment Award, Options, Exercisable, Weighted Average Remaining Contractual Term Weighted - average Contractual Term, Exercisable at December 31, 2015 (in years) Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Intrinsic Value Aggregate Intrinsic Value, Outstanding Beginning Balance Aggregate Intrinsic Value, Outstanding Ending Balance Share-based Compensation Arrangement by Share-based Payment Award, Options, Exercisable, Intrinsic Value Aggregate Intrinsic Value, Exercisable at December 31, 2015 Preferred Stock, Par or Stated Value Per Share Preferred stock, par value (in dollars per share) Preferred Stock, Shares Authorized Preferred stock, shares authorized Preferred Stock, Shares Issued Preferred stock, shares issued Preferred Stock, Shares Outstanding Preferred stock, shares outstanding Common Stock, Par or Stated Value Per Share Common stock, par value (in dollars per share) Common Stock, Shares Authorized Common stock, shares authorized Common Stock, Shares Authorized Common Stock, Shares, Issued Common stock, shares issued Common Stock, Shares, Outstanding Common stock, shares outstanding Treasury Stock, Shares Treasury stock, shares Equity Incentive Plans Restricted Stock Activity [Table] Award Type [Axis] Equity Award [Domain] Restricted Stock [Member] Equity Incentive Plans Restricted Stock Activity [Line Items] Line items represent financial concepts included in a table. These concepts are used to disclose reportable information associated with domain members defined in one or many axes to the table. Share-Based Compensation Arrangement By Share-Based Payment Award, Equity Instruments Other Than Options, Nonvested, Number Number of Shares, Outstanding at Begining Balance Number of Shares, Outstanding at Ending Balance Share-Based Compensation Arrangement By Share-Based Payment Award, Equity Instruments Other Than Options, Grants In Period Number of Shares, Granted Share-Based Compensation Arrangement By Share-Based Payment Award, Equity Instruments Other Than Options, Vested In Period Number of Shares, Vested