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  <element name="ContingentlyIssuableShares" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" nillable="true" xbrli:balance="credit" substitutionGroup="xbrli:item" id="tgtx_ContingentlyIssuableShares" />

  <element name="ScheduleOfWarrantsActivityTableTextBlock" type="nonnum:textBlockItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="tgtx_ScheduleOfWarrantsActivityTableTextBlock" />

  <element name="ScheduleOfShareBasedCompensationExpenseTableTextBlock" type="nonnum:textBlockItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="tgtx_ScheduleOfShareBasedCompensationExpenseTableTextBlock" />

  <element name="SignificantAccountingPoliciesTable" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrldt:hypercubeItem" id="tgtx_SignificantAccountingPoliciesTable" />

  <element name="OpusPointPartnersLlcMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="tgtx_OpusPointPartnersLlcMember" />

  <element name="TgBioMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="tgtx_TgBioMember" />

  <element name="MichaelSweissMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="tgtx_MichaelSweissMember" />

  <element name="SeanPowerMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="tgtx_SeanPowerMember" />

  <element name="VestingPeriodAxis" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrldt:dimensionItem" id="tgtx_VestingPeriodAxis" />

  <element name="VestingPeriodDomain" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="tgtx_VestingPeriodDomain" />

  <element name="November152012Member" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="tgtx_November152012Member" />

  <element name="November152013Member" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="tgtx_November152013Member" />

  <element name="November152014Member" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="tgtx_November152014Member" />

  <element name="November152015Member" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="tgtx_November152015Member" />

  <element name="MarketCapitalizationTargetAxis" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrldt:dimensionItem" id="tgtx_MarketCapitalizationTargetAxis" />

  <element name="MarketCapitalizationTargetDomain" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="tgtx_MarketCapitalizationTargetDomain" />

  <element name="MarketCapitalizationTargetOneMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="tgtx_MarketCapitalizationTargetOneMember" />

  <element name="MarketCapitalizationTargetTwoMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="tgtx_MarketCapitalizationTargetTwoMember" />

  <element name="ImmaterialErrorAxis" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrldt:dimensionItem" id="tgtx_ImmaterialErrorAxis" />

  <element name="ImmaterialErrorDomain" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="tgtx_ImmaterialErrorDomain" />

  <element name="BeforeCorrectionOfImmaterialErrorMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="tgtx_BeforeCorrectionOfImmaterialErrorMember" />

  <element name="AfterCorrectionOfImmaterialErrorMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="tgtx_AfterCorrectionOfImmaterialErrorMember" />

  <element name="SignificantAccountingPoliciesLineItems" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="tgtx_SignificantAccountingPoliciesLineItems" />

  <element name="PeriodAnticipatedSufficientToFundOperatingCashFlow" type="xbrli:durationItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="tgtx_PeriodAnticipatedSufficientToFundOperatingCashFlow" />

  <element name="CashEquivalentsMaturityPeriod" type="xbrli:stringItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="tgtx_CashEquivalentsMaturityPeriod" />

  <element name="FairValueMeasurementChangesInLevel3InstrumentsTable" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrldt:hypercubeItem" id="tgtx_FairValueMeasurementChangesInLevel3InstrumentsTable" />

  <element name="FairValueMeasurementChangesInLevel3InstrumentsLineItems" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="tgtx_FairValueMeasurementChangesInLevel3InstrumentsLineItems" />

  <element name="FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisLiabilityInterestAccruedIncludedInEarnings" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" xbrli:balance="credit" substitutionGroup="xbrli:item" id="tgtx_FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisLiabilityInterestAccruedIncludedInEarnings" />

  <element name="FairValueMeasurementTable" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrldt:hypercubeItem" id="tgtx_FairValueMeasurementTable" />

  <element name="TypeOfTransactionAxis" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrldt:dimensionItem" id="tgtx_TypeOfTransactionAxis" />

  <element name="TypeOfTransactionDomain" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="tgtx_TypeOfTransactionDomain" />

  <element name="ManhattanAndAristonPharmaceuticalsMergerMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="tgtx_ManhattanAndAristonPharmaceuticalsMergerMember" />

  <element name="OtherOperatingCostAndExpenseAxis" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrldt:dimensionItem" id="tgtx_OtherOperatingCostAndExpenseAxis" />

  <element name="OtherOperatingCostAndExpenseDomain" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="tgtx_OtherOperatingCostAndExpenseDomain" />

  <element name="NonrecurringMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="tgtx_NonrecurringMember" />

  <element name="PercentageOfCashProceedsFromOperationToRepayConvertibleDebt" type="num:percentItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="tgtx_PercentageOfCashProceedsFromOperationToRepayConvertibleDebt" />

  <element name="EquityIncentivePlansStockOptionActivityTable" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrldt:hypercubeItem" id="tgtx_EquityIncentivePlansStockOptionActivityTable" />

  <element name="EquityIncentivePlansStockOptionActivityLineItems" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="tgtx_EquityIncentivePlansStockOptionActivityLineItems" />

  <element name="EquityIncentivePlansRestrictedStockActivityTable" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrldt:hypercubeItem" id="tgtx_EquityIncentivePlansRestrictedStockActivityTable" />

  <element name="EquityIncentivePlansRestrictedStockActivityLineItems" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="tgtx_EquityIncentivePlansRestrictedStockActivityLineItems" />

  <element name="EquityIncentivePlansWarrantActivityTable" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrldt:hypercubeItem" id="tgtx_EquityIncentivePlansWarrantActivityTable" />

  <element name="EquityIncentivePlansWarrantActivityLineItems" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="tgtx_EquityIncentivePlansWarrantActivityLineItems" />

  <element name="WarrantOrRightIssued" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="tgtx_WarrantOrRightIssued" />

  <element name="WarrantOrRightExercised" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="tgtx_WarrantOrRightExercised" />

  <element name="WarrantOrRightExpired" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="tgtx_WarrantOrRightExpired" />

  <element name="WarrantOrRightOutstandingWeightedAverageExercisePrice" type="num:perShareItemType" abstract="false" xbrli:periodType="instant" nillable="true" substitutionGroup="xbrli:item" id="tgtx_WarrantOrRightOutstandingWeightedAverageExercisePrice" />

  <element name="WarrantOrRightIssuedWeightedAverageExercisePrice" type="num:perShareItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="tgtx_WarrantOrRightIssuedWeightedAverageExercisePrice" />

  <element name="WarrantOrRightExercisedWeightedAverageExercisePrice" type="num:perShareItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="tgtx_WarrantOrRightExercisedWeightedAverageExercisePrice" />

  <element name="WarrantOrRightExpiredWeightedAverageExercisePrice" type="num:perShareItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="tgtx_WarrantOrRightExpiredWeightedAverageExercisePrice" />

  <element name="WarrantOrRightAggregateIntrinsicValue" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" nillable="true" xbrli:balance="credit" substitutionGroup="xbrli:item" id="tgtx_WarrantOrRightAggregateIntrinsicValue" />

  <element name="StockBasedCompensationTable" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrldt:hypercubeItem" id="tgtx_StockBasedCompensationTable" />

  <element name="StockholdersEquityTable" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrldt:hypercubeItem" id="tgtx_StockholdersEquityTable" />

  <element name="StockOptionPlanMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="tgtx_StockOptionPlanMember" />

  <element name="StockOptionPlan1995Member" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="tgtx_StockOptionPlan1995Member" />

  <element name="IncentivePlanMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="tgtx_IncentivePlanMember" />

  <element name="EquityPipe2011Member" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="tgtx_EquityPipe2011Member" />

  <element name="EquityIncentivePlansMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="tgtx_EquityIncentivePlansMember" />

  <element name="LfbMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="tgtx_LfbMember" />

  <element name="PriorToExecutionOfSecuritiesExchangeAgreementMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="tgtx_PriorToExecutionOfSecuritiesExchangeAgreementMember" />

  <element name="PlacementAgentMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="tgtx_PlacementAgentMember" />

  <element name="CorporateMilestoneAxis" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrldt:dimensionItem" id="tgtx_CorporateMilestoneAxis" />

  <element name="CorporateMilestoneDomain" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="tgtx_CorporateMilestoneDomain" />

  <element name="CorporateMilestoneMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="tgtx_CorporateMilestoneMember" />

  <element name="NonEmployeeStockOptionsAxis" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrldt:dimensionItem" id="tgtx_NonEmployeeStockOptionsAxis" />

  <element name="NonEmployeeStockOptionsDomain" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="tgtx_NonEmployeeStockOptionsDomain" />

  <element name="NonEmployeeStockOptionsMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="tgtx_NonEmployeeStockOptionsMember" />

  <element name="NonEmployeeRestrictedStockMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="tgtx_NonEmployeeRestrictedStockMember" />

  <element name="IssuancePeriodAxis" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrldt:dimensionItem" id="tgtx_IssuancePeriodAxis" />

  <element name="IssuancePeriodDomain" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="tgtx_IssuancePeriodDomain" />

  <element name="TwoThousandElevenIssuanceMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="tgtx_TwoThousandElevenIssuanceMember" />

  <element name="TwoThousandTwelveIssuanceMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="tgtx_TwoThousandTwelveIssuanceMember" />

  <element name="AgreementAxis" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrldt:dimensionItem" id="tgtx_AgreementAxis" />

  <element name="StockIssuedDuringPeriodSharesNewIssuesShelfRegistrationStatement" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" xbrli:balance="credit" substitutionGroup="xbrli:item" id="tgtx_StockIssuedDuringPeriodSharesNewIssuesShelfRegistrationStatement" />

  <element name="PurchasePrice" type="num:perShareItemType" abstract="false" xbrli:periodType="instant" nillable="true" substitutionGroup="xbrli:item" id="tgtx_PurchasePrice" />

  <element name="StockIssuedDuringPeriodSharesNewIssuesOverAllotments" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="tgtx_StockIssuedDuringPeriodSharesNewIssuesOverAllotments" />

  <element name="NetProceedsFromSharesNewIssuesOverallotments" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" xbrli:balance="debit" substitutionGroup="xbrli:item" id="tgtx_NetProceedsFromSharesNewIssuesOverallotments" />

  <element name="UnderwritingDiscountsAndOfferingExpenses" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" xbrli:balance="debit" substitutionGroup="xbrli:item" id="tgtx_UnderwritingDiscountsAndOfferingExpenses" />

  <element name="NotesPayableTable" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrldt:hypercubeItem" id="tgtx_NotesPayableTable" />

  <element name="NoninterestbearingMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="tgtx_NoninterestbearingMember" />

  <element name="ConvertibleNotesMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="tgtx_ConvertibleNotesMember" />

  <element name="IconConvertibleNotesMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="tgtx_IconConvertibleNotesMember" />

  <element name="NotesPayableLineItems" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="tgtx_NotesPayableLineItems" />

  <element name="AmendmentAxis" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrldt:dimensionItem" id="tgtx_AmendmentAxis" />

  <element name="AmendmentDomain" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="tgtx_AmendmentDomain" />

  <element name="BeforeAmendmentMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="tgtx_BeforeAmendmentMember" />

  <element name="AfterAmendmentMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="tgtx_AfterAmendmentMember" />

  <element name="ExchangeTransactionMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="tgtx_ExchangeTransactionMember" />

  <element name="IconClinicalResearchMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="tgtx_IconClinicalResearchMember" />

  <element name="AristonMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="tgtx_AristonMember" />

  <element name="ManhattanMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="tgtx_ManhattanMember" />

  <element name="PercentageOfCashProceedsFromOperationToRepayInterestOnConvertibleDebt" type="num:percentItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="tgtx_PercentageOfCashProceedsFromOperationToRepayInterestOnConvertibleDebt" />

  <element name="DebtInstrumentSettlementOfPrincipalAndInterest" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" xbrli:balance="debit" substitutionGroup="xbrli:item" id="tgtx_DebtInstrumentSettlementOfPrincipalAndInterest" />

  <element name="DebtInstrumentgainOnSettlement" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" xbrli:balance="credit" substitutionGroup="xbrli:item" id="tgtx_DebtInstrumentgainOnSettlement" />

  <element name="LicenseAgreementTable" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrldt:hypercubeItem" id="tgtx_LicenseAgreementTable" />

  <element name="LfbBiotechnologiesMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="tgtx_LfbBiotechnologiesMember" />

  <element name="CollaborationAgreementMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="tgtx_CollaborationAgreementMember" />

  <element name="LigandMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="tgtx_LigandMember" />

  <element name="AdditionalAmountReceivableOnAchievementOfPreSpecifiedMilestones" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" xbrli:balance="debit" substitutionGroup="xbrli:item" id="tgtx_AdditionalAmountReceivableOnAchievementOfPreSpecifiedMilestones" />

  <element name="NonCashStockExpense" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" xbrli:balance="debit" substitutionGroup="xbrli:item" id="tgtx_NonCashStockExpense" />

  <element name="MaximumPotentialPaymentsPayable" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" xbrli:balance="credit" substitutionGroup="xbrli:item" id="tgtx_MaximumPotentialPaymentsPayable" />

  <element name="RoyaltyPaymentEffectivePercentage" type="num:percentItemType" abstract="false" xbrli:periodType="instant" nillable="true" substitutionGroup="xbrli:item" id="tgtx_RoyaltyPaymentEffectivePercentage" />

  <element name="MaximumSalesForRoyaltyExpense" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" xbrli:balance="credit" substitutionGroup="xbrli:item" id="tgtx_MaximumSalesForRoyaltyExpense" />

  <element name="PlacementAgencyAgreementAxis" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrldt:dimensionItem" id="tgtx_PlacementAgencyAgreementAxis" />

  <element name="PlacementAgencyAgreementDomain" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="tgtx_PlacementAgencyAgreementDomain" />

  <element name="LfbGroupMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="tgtx_LfbGroupMember" />

  <element name="PlacementAgencyAgreementMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="tgtx_PlacementAgencyAgreementMember" />

  <element name="RhizenMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="tgtx_RhizenMember" />

  <element name="ResearchDevelopmentExpensesAxis" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrldt:dimensionItem" id="tgtx_ResearchDevelopmentExpensesAxis" />

  <element name="ResearchDevelopmentExpensesDomain" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="tgtx_ResearchDevelopmentExpensesDomain" />

  <element name="ResearchDevelopmentExpensesMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="tgtx_ResearchDevelopmentExpensesMember" />

  <element name="OpusMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="tgtx_OpusMember" />

  <element name="NationalHoldingsMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="tgtx_NationalHoldingsMember" />

  <element name="AgreementTypeAxis" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrldt:dimensionItem" id="tgtx_AgreementTypeAxis" />

  <element name="NumberOfCommonStockSharesGrantedInConnectionWithLicenseAgreementByIssueOfWarrants" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="tgtx_NumberOfCommonStockSharesGrantedInConnectionWithLicenseAgreementByIssueOfWarrants" />

  <element name="CommonStockPurchasePricePerShare" type="num:perShareItemType" abstract="false" xbrli:periodType="instant" nillable="true" substitutionGroup="xbrli:item" id="tgtx_CommonStockPurchasePricePerShare" />

  <element name="SeriesParticipatingPreferredStockMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="tgtx_SeriesParticipatingPreferredStockMember" />

  <element name="NonCashCompensationResearchAndDevelopmentExpenses" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" xbrli:balance="debit" substitutionGroup="xbrli:item" id="tgtx_NonCashCompensationResearchAndDevelopmentExpenses" />

  <element name="NonCashCompensationGeneralAndAdministrativeExpenses" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" xbrli:balance="debit" substitutionGroup="xbrli:item" id="tgtx_NonCashCompensationGeneralAndAdministrativeExpenses" />

  <element name="ChangeInFairValueOfNonCurrentNotePayable" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" xbrli:balance="credit" substitutionGroup="xbrli:item" id="tgtx_ChangeInFairValueOfNonCurrentNotePayable" />

  <element name="CompensationAxis" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrldt:dimensionItem" id="tgtx_CompensationAxis" />

  <element name="CompensationDomain" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="tgtx_CompensationDomain" />

  <element name="RestrictedPreferredStockMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="tgtx_RestrictedPreferredStockMember" />

  <element name="RestrictedCommonStockMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="tgtx_RestrictedCommonStockMember" />

  <element name="ContingentlyIssuableShareMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="tgtx_ContingentlyIssuableShareMember" />

  <element name="StockIssuedDuringPeriodValueExerciseOfWarrants" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" xbrli:balance="credit" substitutionGroup="xbrli:item" id="tgtx_StockIssuedDuringPeriodValueExerciseOfWarrants" />

  <element name="StockIssuedDuringPeriodSharesExerciseOfWarrants" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="tgtx_StockIssuedDuringPeriodSharesExerciseOfWarrants" />

  <element name="StockIssuedDuringPeriodValueExerciseOfWarrantsCashLess" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" xbrli:balance="credit" substitutionGroup="xbrli:item" id="tgtx_StockIssuedDuringPeriodValueExerciseOfWarrantsCashLess" />

  <element name="StockIssuedDuringPeriodSharesExerciseOfWarrantsCashLess" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="tgtx_StockIssuedDuringPeriodSharesExerciseOfWarrantsCashLess" />

  <element name="ExchangeForLicenseOptionMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="tgtx_ExchangeForLicenseOptionMember" />

  <element name="SharesIssuedInConnectionWithInLicensingAgreement" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" xbrli:balance="debit" substitutionGroup="xbrli:item" id="tgtx_SharesIssuedInConnectionWithInLicensingAgreement" />

  <element name="ImpairmentOfInProcessResearchAndDevelopment" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" xbrli:balance="debit" substitutionGroup="xbrli:item" id="tgtx_ImpairmentOfInProcessResearchAndDevelopment" />

  <element name="ChangeInFairValueOfNotesPayable" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" xbrli:balance="credit" substitutionGroup="xbrli:item" id="tgtx_ChangeInFairValueOfNotesPayable" />

  <element name="PaymentsToAcquireHeldToMaturitySecuritiesLongTerm" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" xbrli:balance="credit" substitutionGroup="xbrli:item" id="tgtx_PaymentsToAcquireHeldToMaturitySecuritiesLongTerm" />

  <element name="PaymentsToAcquireHeldToMaturitySecuritiesShortTerm" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" xbrli:balance="credit" substitutionGroup="xbrli:item" id="tgtx_PaymentsToAcquireHeldToMaturitySecuritiesShortTerm" />

  <element name="CornadoBiosciencesMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="tgtx_CornadoBiosciencesMember" />

  <element name="SaleBasedMileStonePayment" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" xbrli:balance="debit" substitutionGroup="xbrli:item" id="tgtx_SaleBasedMileStonePayment" />

  <element name="NonCashResearchAndDevelopmentExpense" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" xbrli:balance="debit" substitutionGroup="xbrli:item" id="tgtx_NonCashResearchAndDevelopmentExpense" />

  <element name="StockIssuedDuringPeriodValueMarketPublicOffering" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" xbrli:balance="credit" substitutionGroup="xbrli:item" id="tgtx_StockIssuedDuringPeriodValueMarketPublicOffering" />

  <element name="AgreementDomain" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="tgtx_AgreementDomain" />

  <element name="AtmMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="tgtx_AtmMember" />

  <element name="StockIssuedDuringPeriodSharesMarketPublicOffering" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="tgtx_StockIssuedDuringPeriodSharesMarketPublicOffering" />

  <element name="CommonStockValueReservedForFutureIssuance" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" xbrli:balance="credit" substitutionGroup="xbrli:item" id="tgtx_CommonStockValueReservedForFutureIssuance" />

  <element name="StockholdersEquityLineItems" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="tgtx_StockholdersEquityLineItems" />

  <element name="FairValueMeasurementLineItems" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="tgtx_FairValueMeasurementLineItems" />

  <element name="DeferredTaxAssetsAndLiabilitiesTable" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrldt:hypercubeItem" id="tgtx_DeferredTaxAssetsAndLiabilitiesTable" />

  <element name="DeferredTaxAssetsAndLiabilitiesLineItems" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="tgtx_DeferredTaxAssetsAndLiabilitiesLineItems" />

  <element name="ScheduleOfDeferredTaxAssetsAndLiabilitiesAbstract" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="tgtx_ScheduleOfDeferredTaxAssetsAndLiabilitiesAbstract" />

  <element name="UpfrontFeeReceivedFromSubLicense" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" xbrli:balance="credit" substitutionGroup="xbrli:item" id="tgtx_UpfrontFeeReceivedFromSubLicense" />

  <element name="UsFederalIncomeTaxMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="tgtx_UsFederalIncomeTaxMember" />

  <element name="OperatingLossCarryForwardsExpirationPeriod" type="xbrli:stringItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="tgtx_OperatingLossCarryForwardsExpirationPeriod" />

  <element name="TreasuryStockValueDuringPeirod" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" xbrli:balance="credit" substitutionGroup="xbrli:item" id="tgtx_TreasuryStockValueDuringPeirod" />

  <element name="TreasuryStockSharesDuringPeirod" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="tgtx_TreasuryStockSharesDuringPeirod" />

  <element name="DeskAgreementMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="tgtx_DeskAgreementMember" />

  <element name="SeriesJuniorParticipatingPreferredStockMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="tgtx_SeriesJuniorParticipatingPreferredStockMember" />

  <element name="StockholderRightsPlanDescription" type="xbrli:stringItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="tgtx_StockholderRightsPlanDescription" />

  <element name="TotalAuthorizedShareCapital" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="instant" nillable="true" substitutionGroup="xbrli:item" id="tgtx_TotalAuthorizedShareCapital" />

  <element name="DecreaseAuthorizedShareCapital" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="instant" nillable="true" substitutionGroup="xbrli:item" id="tgtx_DecreaseAuthorizedShareCapital" />

  <element name="RoyaltyRevenueDiscription" type="xbrli:stringItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="tgtx_RoyaltyRevenueDiscription" />

  <element name="LeasePaymentTerm" type="xbrli:stringItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="tgtx_LeasePaymentTerm" />

  <element name="ImpairmentOfTangibleAndIntangibleAssetIncludingGoodwillPolicyTextBlock" type="nonnum:textBlockItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="tgtx_ImpairmentOfTangibleAndIntangibleAssetIncludingGoodwillPolicyTextBlock" />

  <element name="AgreementTypeNameDomain" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="tgtx_AgreementTypeNameDomain" />

  <element name="LfbLicenseAgreementMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="tgtx_LfbLicenseAgreementMember" />

  <element name="AverageAnnualRentalPayments" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" nillable="true" xbrli:balance="debit" substitutionGroup="xbrli:item" id="tgtx_AverageAnnualRentalPayments" />

  <element name="PercentageOfOccupancy" type="num:percentItemType" abstract="false" xbrli:periodType="instant" nillable="true" substitutionGroup="xbrli:item" id="tgtx_PercentageOfOccupancy" />

  <element name="MinimumValueOfSharesToBePurchased" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" xbrli:balance="credit" substitutionGroup="xbrli:item" id="tgtx_MinimumValueOfSharesToBePurchased" />

  <element name="CheckpointTherapeuticsCollaborationAgreementMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="tgtx_CheckpointTherapeuticsCollaborationAgreementMember" />

  <element name="DevelopmentAndSalesBasedMilestonePaymentsMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="tgtx_DevelopmentAndSalesBasedMilestonePaymentsMember" />

  <element name="MaximumSecuritiesToBeSold" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" xbrli:balance="credit" substitutionGroup="xbrli:item" id="tgtx_MaximumSecuritiesToBeSold" />

  <element name="OfferingPriceAdditionalSharesToBeIssued" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" xbrli:balance="credit" substitutionGroup="xbrli:item" id="tgtx_OfferingPriceAdditionalSharesToBeIssued" />

  <element name="MlvCoLlcMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="tgtx_MlvCoLlcMember" />

  <element name="AtthemarketIssuanceSalesAgreement2015Member" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="tgtx_AtthemarketIssuanceSalesAgreement2015Member" />

  <element name="CommissionRate" type="num:percentItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="tgtx_CommissionRate" />

  <element name="LicenseAgreementLineItems" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="tgtx_LicenseAgreementLineItems" />
</schema>

