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<import namespace="http://www.xbrl.org/2003/instance" schemaLocation="http://www.xbrl.org/2003/xbrl-instance-2003-12-31.xsd"/>
<import namespace="http://www.xbrl.org/2003/linkbase" schemaLocation="http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd"/>
<import namespace="http://xbrl.org/2005/xbrldt" schemaLocation="http://www.xbrl.org/2005/xbrldt-2005.xsd"/>
<import namespace="http://fasb.org/us-gaap/2012-01-31" schemaLocation="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd"/>
<import namespace="http://xbrl.sec.gov/invest/2012-01-31" schemaLocation="http://xbrl.sec.gov/invest/2012/invest-2012-01-31.xsd"/>
<import namespace="http://xbrl.sec.gov/country/2012-01-31" schemaLocation="http://xbrl.sec.gov/country/2012/country-2012-01-31.xsd"/>
<import namespace="http://xbrl.sec.gov/currency/2012-01-31" schemaLocation="http://xbrl.sec.gov/currency/2012/currency-2012-01-31.xsd"/>
<import namespace="http://xbrl.sec.gov/exch/2012-01-31" schemaLocation="http://xbrl.sec.gov/exch/2012/exch-2012-01-31.xsd"/>
<import namespace="http://xbrl.sec.gov/naics/2011-01-31" schemaLocation="http://xbrl.sec.gov/naics/2011/naics-2011-01-31.xsd"/>
<import namespace="http://xbrl.sec.gov/sic/2011-01-31" schemaLocation="http://xbrl.sec.gov/sic/2011/sic-2011-01-31.xsd"/>
<import namespace="http://xbrl.sec.gov/stpr/2011-01-31" schemaLocation="http://xbrl.sec.gov/stpr/2011/stpr-2011-01-31.xsd"/>
<import namespace="http://www.xbrl.org/2009/role/negated" schemaLocation="http://www.xbrl.org/lrr/role/negated-2009-12-16.xsd"/>
<import namespace="http://www.xbrl.org/2009/role/net" schemaLocation="http://www.xbrl.org/lrr/role/net-2009-12-16.xsd"/>
<import namespace="http://www.xbrl.org/2009/arcrole/fact-explanatoryFact" schemaLocation="http://www.xbrl.org/lrr/arcrole/factExplanatory-2009-12-16.xsd"/>
<import namespace="http://xbrl.sec.gov/dei/2012-01-31" schemaLocation="http://xbrl.sec.gov/dei/2012/dei-2012-01-31.xsd"/>
<import namespace="http://www.xbrl.org/dtr/type/numeric" schemaLocation="http://www.xbrl.org/dtr/type/numeric-2009-12-16.xsd"/>
<import namespace="http://www.xbrl.org/dtr/type/non-numeric" schemaLocation="http://www.xbrl.org/dtr/type/nonNumeric-2009-12-16.xsd"/>
<import namespace="http://fasb.org/us-types/2012-01-31" schemaLocation="http://xbrl.fasb.org/us-gaap/2012/elts/us-types-2012-01-31.xsd"/>
<element name="DocumentAndEntityInformationAbstract" id="tgtx_DocumentAndEntityInformationAbstract" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="PrepaidResearchAndDevelopment" id="tgtx_PrepaidResearchAndDevelopment" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item"/>
<element name="InProcessResearchAndDevelopment" id="tgtx_InProcessResearchAndDevelopment" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item"/>
<element name="ContingentlyIssuableShares" id="tgtx_ContingentlyIssuableShares" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" xbrli:balance="credit" nillable="true" substitutionGroup="xbrli:item"/>
<element name="NonCashStockExpense" id="tgtx_NonCashStockExpense" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item"/>
<element name="NonCashCompensationResearchAndDevelopmentExpenses" id="tgtx_NonCashCompensationResearchAndDevelopmentExpenses" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item"/>
<element name="OtherResearchAndDevelopment" id="tgtx_OtherResearchAndDevelopment" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item"/>
<element name="NonCashCompensationGeneralAndAdministrativeExpenses" id="tgtx_NonCashCompensationGeneralAndAdministrativeExpenses" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item"/>
<element name="ImpairmentOfInprocessResearchAndDevelopment" id="tgtx_ImpairmentOfInprocessResearchAndDevelopment" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" abstract="false" xbrli:balance="debit" nillable="true"/>

<element name="ChangeInFairValueOfNonCurrentNotePayable" id="tgtx_ChangeInFairValueOfNonCurrentNotePayable" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="credit" nillable="true" substitutionGroup="xbrli:item"/>
<element name="NonControllingInterestInSubsidiaryMember" id="tgtx_NonControllingInterestInSubsidiaryMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="CommonStockIssuedDuringPeriodValueToFoundersInExchangeForSeedCapital" id="tgtx_CommonStockIssuedDuringPeriodValueToFoundersInExchangeForSeedCapital" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="credit" nillable="true" substitutionGroup="xbrli:item"/>
<element name="CommonStockIssuedDuringPeriodSharesToFoundersInExchangeForSeedCapital" id="tgtx_CommonStockIssuedDuringPeriodSharesToFoundersInExchangeForSeedCapital" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="CommonStockIssuedDuringPeriodValueInExchangeForLicenseOption" id="tgtx_CommonStockIssuedDuringPeriodValueInExchangeForLicenseOption" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="credit" nillable="true" substitutionGroup="xbrli:item"/>
<element name="CommonStockIssuedDuringPeriodSharesInExchangeForLicenseOption" id="tgtx_CommonStockIssuedDuringPeriodSharesInExchangeForLicenseOption" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="StockIssuedDuringPeriodValueConversionOfNotePayableToPreferredStock" id="tgtx_StockIssuedDuringPeriodValueConversionOfNotePayableToPreferredStock" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="credit" nillable="true" substitutionGroup="xbrli:item"/>
<element name="StockIssuedDuringPeriodSharesConversionOfNotePayableToPreferredStock" id="tgtx_StockIssuedDuringPeriodSharesConversionOfNotePayableToPreferredStock" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="StockIssuedDuringPeriodValueOfReplacementRestrictedPreferredStockToEmployees" id="tgtx_StockIssuedDuringPeriodValueOfReplacementRestrictedPreferredStockToEmployees" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="credit" nillable="true" substitutionGroup="xbrli:item"/>
<element name="StockIssuedDuringPeriodSharesOfReplacementRestrictedPreferredStockToEmployees" id="tgtx_StockIssuedDuringPeriodSharesOfReplacementRestrictedPreferredStockToEmployees" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="StockIssuedDuringPeriodStockNewIssuesNetOfExpenses" id="tgtx_StockIssuedDuringPeriodStockNewIssuesNetOfExpenses" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="SharesIssuedToNonControllingInterestInConnectionWithLicensingAgreement" id="tgtx_SharesIssuedToNonControllingInterestInConnectionWithLicensingAgreement" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="credit" nillable="true" substitutionGroup="xbrli:item"/>
<element name="NonControllingInterestSubsidiarySharesValue" id="tgtx_NonControllingInterestSubsidiarySharesValue" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="credit" nillable="true" substitutionGroup="xbrli:item"/>
<element name="NonControllingInterestSubsidiaryShares" id="tgtx_NonControllingInterestSubsidiaryShares" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="TreasuryStockValueDuringPeirod" id="tgtx_TreasuryStockValueDuringPeirod" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="credit" nillable="true" substitutionGroup="xbrli:item"/>
<element name="TreasuryStockSharesDuringPeirod" id="tgtx_TreasuryStockSharesDuringPeirod" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="ExchangeForLicenseOptionMember" id="tgtx_ExchangeForLicenseOptionMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="NewStockIssuedMember" id="tgtx_NewStockIssuedMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="FairValuePerShareIssued" id="tgtx_FairValuePerShareIssued" type="num:perShareItemType" abstract="false" xbrli:periodType="instant" nillable="true" substitutionGroup="xbrli:item"/>
<element name="PreferredStockIssued" id="tgtx_PreferredStockIssued" type="num:perShareItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="SharesIssuedInConnectionWithInLicensingAgreement" id="tgtx_SharesIssuedInConnectionWithInLicensingAgreement" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="credit" nillable="true" substitutionGroup="xbrli:item"/>
<element name="ChangeInFairValueOfNotesPayable" id="tgtx_ChangeInFairValueOfNotesPayable" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="credit" nillable="true" substitutionGroup="xbrli:item"/>
<element name="ConversionOfNotesPayableToPreferredStock" id="tgtx_ConversionOfNotesPayableToPreferredStock" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item"/>
<element name="AccruedFinancingCosts" id="tgtx_AccruedFinancingCosts" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item"/>
<element name="LicenseagreementAbstract" id="tgtx_LicenseagreementAbstract" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="LicenseAgreementDisclosureTextBlock" id="tgtx_LicenseAgreementDisclosureTextBlock" type="nonnum:textBlockItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="BusinessDescriptionPolicyTextBlock" id="tgtx_BusinessDescriptionPolicyTextBlock" type="nonnum:textBlockItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>

<element name="ReverseStockSplitPolicyTextBlock" id="tgtx_ReverseStockSplitPolicyTextBlock" type="nonnum:textBlockItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="ManagementChangesPolicyTextBlock" id="tgtx_ManagementChangesPolicyTextBlock" type="nonnum:textBlockItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="ImpairmentOfTangibleAndIntangibleAssetIncludingGoodwillPolicyTextBlock" id="tgtx_ImpairmentOfTangibleAndIntangibleAssetIncludingGoodwillPolicyTextBlock" type="nonnum:textBlockItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="ScheduleOfPurchasePriceConsiderationTableTextBlock" id="tgtx_ScheduleOfPurchasePriceConsiderationTableTextBlock" type="nonnum:textBlockItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="PreferredRestrictedStockMember" id="tgtx_PreferredRestrictedStockMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="CommonRestrictedStockMember" id="tgtx_CommonRestrictedStockMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="ScheduleOfWarrantsActivityTableTextBlock" id="tgtx_ScheduleOfWarrantsActivityTableTextBlock" type="nonnum:textBlockItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="ScheduleOfShareBasedCompensationExpenseTableTextBlock" id="tgtx_ScheduleOfShareBasedCompensationExpenseTableTextBlock" type="nonnum:textBlockItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="OpusPointPartnersLlcMember" id="tgtx_OpusPointPartnersLlcMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="TgBioMember" id="tgtx_TgBioMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="MichaelSweissMember" id="tgtx_MichaelSweissMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="SeanPowerMember" id="tgtx_SeanPowerMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="MrPowerMember" id="tgtx_MrPowerMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="MrWeissMember" id="tgtx_MrWeissMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="VestingPeriodAxis" id="tgtx_VestingPeriodAxis" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrldt:dimensionItem"/>
<element name="VestingPeriodDomain" id="tgtx_VestingPeriodDomain" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="November152012Member" id="tgtx_November152012Member" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="November152013Member" id="tgtx_November152013Member" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="November152014Member" id="tgtx_November152014Member" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="November152015Member" id="tgtx_November152015Member" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="MarketCapitalizationTargetAxis" id="tgtx_MarketCapitalizationTargetAxis" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrldt:dimensionItem"/>
<element name="MarketCapitalizationTargetDomain" id="tgtx_MarketCapitalizationTargetDomain" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="MarketCapitalizationTargetOneMember" id="tgtx_MarketCapitalizationTargetOneMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="MarketCapitalizationTargetTwoMember" id="tgtx_MarketCapitalizationTargetTwoMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="ImmaterialErrorAxis" id="tgtx_ImmaterialErrorAxis" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrldt:dimensionItem"/>
<element name="ImmaterialErrorDomain" id="tgtx_ImmaterialErrorDomain" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="BeforeCorrectionOfImmaterialErrorMember" id="tgtx_BeforeCorrectionOfImmaterialErrorMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="AfterCorrectionOfImmaterialErrorMember" id="tgtx_AfterCorrectionOfImmaterialErrorMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="PlacementAgentCommisionDescription" id="tgtx_PlacementAgentCommisionDescription" type="xbrli:stringItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="PaymentsOfPlacementAgentCommisions" id="tgtx_PaymentsOfPlacementAgentCommisions" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item"/>
<element name="PercentageOfReductionInSalaryUponResignationfromInterimRoles" id="tgtx_PercentageOfReductionInSalaryUponResignationfromInterimRoles" type="num:percentItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="PercentageOfOutstandingSharesGrantedAnnually" id="tgtx_PercentageOfOutstandingSharesGrantedAnnually" type="num:percentItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="PercentageOfAnnualGrantsRestrictedStockThatWillVestAndBecomeNonforfeitableOnFirstAnniversary" id="tgtx_PercentageOfAnnualGrantsRestrictedStockThatWillVestAndBecomeNonforfeitableOnFirstAnniversary" type="num:percentItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="PercentageOfAnnualGrantsRestrictedStockThatWillVestAndBecomeNonforfeitableOnSecondAniversary" id="tgtx_PercentageOfAnnualGrantsRestrictedStockThatWillVestAndBecomeNonforfeitableOnSecondAniversary" type="num:percentItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="MarketCapitalizationIncreaseToTriggerRestrictedStockThatWillVestAndBecomeNonforfeitable" id="tgtx_MarketCapitalizationIncreaseToTriggerRestrictedStockThatWillVestAndBecomeNonforfeitable" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" abstract="false" xbrli:balance="credit" nillable="true"/>

<element name="PercentageOfRestrictedStockThatWillVestAndBecomeNonforfeitableUponMarketCapitalizationIncrease" id="tgtx_PercentageOfRestrictedStockThatWillVestAndBecomeNonforfeitableUponMarketCapitalizationIncrease" type="num:percentItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="PercentageOfStockIssuedAfterExchangeTransaction" id="tgtx_PercentageOfStockIssuedAfterExchangeTransaction" type="num:percentItemType" abstract="false" xbrli:periodType="instant" nillable="true" substitutionGroup="xbrli:item"/>
<element name="NumberOfSharesVestingSchedule" id="tgtx_NumberOfSharesVestingSchedule" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="instant" nillable="true" substitutionGroup="xbrli:item"/>
<element name="BusinessAcquisitionSharesNotSurrendered" id="tgtx_BusinessAcquisitionSharesNotSurrendered" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="instant" nillable="true" substitutionGroup="xbrli:item"/>
<element name="BusinessAcquisitionSharesRepurchasedPercentage" id="tgtx_BusinessAcquisitionSharesRepurchasedPercentage" type="num:percentItemType" abstract="false" xbrli:periodType="instant" nillable="true" substitutionGroup="xbrli:item"/>
<element name="PeriodAnticipatedSufficientToFundOperatingCashFlow" id="tgtx_PeriodAnticipatedSufficientToFundOperatingCashFlow" type="xbrli:stringItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="DecreaseToTotalAssetsAndLiabilities" id="tgtx_DecreaseToTotalAssetsAndLiabilities" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" xbrli:balance="credit" nillable="true" substitutionGroup="xbrli:item"/>
<element name="FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisLiabilityInterestAccruedIncludedInEarnings" id="tgtx_FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisLiabilityInterestAccruedIncludedInEarnings" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="credit" nillable="true" substitutionGroup="xbrli:item"/>
<element name="NonrecurringMember" id="tgtx_NonrecurringMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="ImpairmentChargeMember" id="tgtx_ImpairmentChargeMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="TypeOfTransactionAxis" id="tgtx_TypeOfTransactionAxis" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrldt:dimensionItem"/>
<element name="TypeOfTransactionDomain" id="tgtx_TypeOfTransactionDomain" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="ManhattanAndAristonPharmaceuticalsMergerMember" id="tgtx_ManhattanAndAristonPharmaceuticalsMergerMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="DebtInstrumentMaturityPeriod" id="tgtx_DebtInstrumentMaturityPeriod" type="xbrli:durationItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="PercentageOfCashProceedsFromOperationToRepayConvertibleDebt" id="tgtx_PercentageOfCashProceedsFromOperationToRepayConvertibleDebt" type="num:percentItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="BusinessAcquisitionSharesOutstandingAcquiredEntity" id="tgtx_BusinessAcquisitionSharesOutstandingAcquiredEntity" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="BusinessAcquisitionFairValueOfCommonStockOutstandingPerShare" id="tgtx_BusinessAcquisitionFairValueOfCommonStockOutstandingPerShare" type="num:perShareItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="BusinessAcquisitionFairValueOfCommonStockOutstanding" id="tgtx_BusinessAcquisitionFairValueOfCommonStockOutstanding" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" xbrli:balance="credit" nillable="true" substitutionGroup="xbrli:item"/>
<element name="BusinessAcquisitionFairValueOfRestrictedSharesAcquired" id="tgtx_BusinessAcquisitionFairValueOfRestrictedSharesAcquired" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" xbrli:balance="credit" nillable="true" substitutionGroup="xbrli:item"/>
<element name="IconAndSwissPharmaMember" id="tgtx_IconAndSwissPharmaMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="ExcludingIconAndSwissPharmaMember" id="tgtx_ExcludingIconAndSwissPharmaMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="BusinessAcquisitionPurchasePriceAllocationAccountsPayableAndAccruedLiablities" id="tgtx_BusinessAcquisitionPurchasePriceAllocationAccountsPayableAndAccruedLiablities" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item"/>
<element name="BusinessAcquisitionPurchasePriceAllocationAssetsAcquiredLiabilitiesAssumedNetBeforeAllocationOfGoodwill" id="tgtx_BusinessAcquisitionPurchasePriceAllocationAssetsAcquiredLiabilitiesAssumedNetBeforeAllocationOfGoodwill" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" xbrli:balance="credit" nillable="true" substitutionGroup="xbrli:item"/>
<element name="BusinessAcquisitionProformaEarningsPerShareBasicAndDiluted" id="tgtx_BusinessAcquisitionProformaEarningsPerShareBasicAndDiluted" type="num:perShareItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="BusinessAcquisitionEquityInterestsIssuedOrIssuableParValueOfShare" id="tgtx_BusinessAcquisitionEquityInterestsIssuedOrIssuableParValueOfShare" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="FairValueOfShares" id="tgtx_FairValueOfShares" type="num:perShareItemType" abstract="false" xbrli:periodType="instant" nillable="true" substitutionGroup="xbrli:item"/>
<element name="ShareholdersDescriptionNoteParticipatedInExchangeTransaction" id="tgtx_ShareholdersDescriptionNoteParticipatedInExchangeTransaction" type="xbrli:stringItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsAssumedInExchangeTransaction" id="tgtx_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsAssumedInExchangeTransaction" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsAssumedInExchangeTransactionWeightedAverageExercisePrice" id="tgtx_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsAssumedInExchangeTransactionWeightedAverageExercisePrice" type="num:perShareItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="ShareBasedCompensationArrangementBySharebasedPaymentAwardOptionsAssumedInExchangeTransactionWeightedAverageRemainingContractualTerm" id="tgtx_ShareBasedCompensationArrangementBySharebasedPaymentAwardOptionsAssumedInExchangeTransactionWeightedAverageRemainingContractualTerm" type="xbrli:durationItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="SharesbasedCompensationArrangementBySharesbasedPaymentAwardOptionsOutstandingWeightedAverageRemainingContractualTerm" id="tgtx_SharesbasedCompensationArrangementBySharesbasedPaymentAwardOptionsOutstandingWeightedAverageRemainingContractualTerm" type="xbrli:durationItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="ConversionOfPreferredStockToRestrictedCommonStock" id="tgtx_ConversionOfPreferredStockToRestrictedCommonStock" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="ConversionOfCommonStockToRestrictedPrererredStockWeightedAverageGrantDateFairValue" id="tgtx_ConversionOfCommonStockToRestrictedPrererredStockWeightedAverageGrantDateFairValue" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="ConversionOfPreferredStockToRestrictedCommonStockWeightedAverageGrantDateFairValue" id="tgtx_ConversionOfPreferredStockToRestrictedCommonStockWeightedAverageGrantDateFairValue" type="num:perShareItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="WarrantsOrRightsAssumedInExchangeTransaction" id="tgtx_WarrantsOrRightsAssumedInExchangeTransaction" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="WarrantOrRightIssued" id="tgtx_WarrantOrRightIssued" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="WarrantOrRightExcersiced" id="tgtx_WarrantOrRightExcersiced" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="WarrantOrRightExpired" id="tgtx_WarrantOrRightExpired" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="WarrantOrRightOutstandingWeightedAverageExercisePrice" id="tgtx_WarrantOrRightOutstandingWeightedAverageExercisePrice" type="num:perShareItemType" abstract="false" xbrli:periodType="instant" nillable="true" substitutionGroup="xbrli:item"/>
<element name="WarrantsOrRightsAssumedInExchangeTransactionWeightedAverageExercisePrice" id="tgtx_WarrantsOrRightsAssumedInExchangeTransactionWeightedAverageExercisePrice" type="num:perShareItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="WarrantOrRightIssuedWeightedAverageExercisePrice" id="tgtx_WarrantOrRightIssuedWeightedAverageExercisePrice" type="num:perShareItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="WarrantOrRightExercisedWeightedAverageExercisePrice" id="tgtx_WarrantOrRightExercisedWeightedAverageExercisePrice" type="num:perShareItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="WarrantOrRightExpiredWeightedAverageExercisePrice" id="tgtx_WarrantOrRightExpiredWeightedAverageExercisePrice" type="num:perShareItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="WarrantOrRightAggregateIntrinsicValue" id="tgtx_WarrantOrRightAggregateIntrinsicValue" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" xbrli:balance="credit" nillable="true" substitutionGroup="xbrli:item"/>
<element name="StockOptionPlanMember" id="tgtx_StockOptionPlanMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="StockOptionPlan1995Member" id="tgtx_StockOptionPlan1995Member" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="TwoThousandTwelveIssuanceMember" id="tgtx_TwoThousandTwelveIssuanceMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="IncentivePlanMember" id="tgtx_IncentivePlanMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="EquityPipe2011Member" id="tgtx_EquityPipe2011Member" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="LfbMember" id="tgtx_LfbMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="PriorToExecutionOfSecuritiesExchangeAgreementMember" id="tgtx_PriorToExecutionOfSecuritiesExchangeAgreementMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="PlacementAgentMember" id="tgtx_PlacementAgentMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="CorporateMileStoneAxis" id="tgtx_CorporateMileStoneAxis" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrldt:dimensionItem"/>
<element name="CorporateMileStoneDomain" id="tgtx_CorporateMileStoneDomain" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="CorporateMileStoneMember" id="tgtx_CorporateMileStoneMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="NonEmployeeStockOptionsAxis" id="tgtx_NonEmployeeStockOptionsAxis" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrldt:dimensionItem"/>
<element name="NonEmployeeStockOptionsDomain" id="tgtx_NonEmployeeStockOptionsDomain" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="NonEmployeeStockOptionsMember" id="tgtx_NonEmployeeStockOptionsMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="NonEmployeeRestrictedStockMember" id="tgtx_NonEmployeeRestrictedStockMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="ConvertiblePreferredStockShareConvertedIntoCommonStock" id="tgtx_ConvertiblePreferredStockShareConvertedIntoCommonStock" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" abstract="false" nillable="true"/>

<element name="StockIssuedDuringPeriodShareSnewIssuesIssuePrice" id="tgtx_StockIssuedDuringPeriodShareSnewIssuesIssuePrice" type="num:perShareItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="ClassOfWarrantOrRightsExercisablePeriod" id="tgtx_ClassOfWarrantOrRightsExercisablePeriod" type="xbrli:durationItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="AgentCashCommissionPercentageOnProceedsFromSharesIssuance" id="tgtx_AgentCashCommissionPercentageOnProceedsFromSharesIssuance" type="num:percentItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostYetToBeRecognized" id="tgtx_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostYetToBeRecognized" type="xbrli:stringItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="PreferredStockToCommonStockConversionBasisPerShare" id="tgtx_PreferredStockToCommonStockConversionBasisPerShare" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="instant" nillable="true" substitutionGroup="xbrli:item"/>
<element name="ShareBasedCompensationNonEmployeeStockOptionsOutstanding" id="tgtx_ShareBasedCompensationNonEmployeeStockOptionsOutstanding" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="instant" nillable="true" substitutionGroup="xbrli:item"/>
<element name="EmployeeServiceShareBasedCompensationNonvestedAwardTotalCompensationCostYetToBeRecognized" id="tgtx_EmployeeServiceShareBasedCompensationNonvestedAwardTotalCompensationCostYetToBeRecognized" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="instant" nillable="true" substitutionGroup="xbrli:item"/>
<element name="WarrantTerm" id="tgtx_WarrantTerm" type="xbrli:durationItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsMaximumTerm" id="tgtx_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsMaximumTerm" type="xbrli:durationItemType" abstract="false" xbrli:periodType="instant" nillable="true" substitutionGroup="xbrli:item"/>
<element name="ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsIssued" id="tgtx_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsIssued" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="instant" nillable="true" substitutionGroup="xbrli:item"/>
<element name="CommonStockPivatePlacement" id="tgtx_CommonStockPivatePlacement" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="instant" nillable="true" substitutionGroup="xbrli:item"/>
<element name="PercentageOfGrossProceedsFromOfferingAsAllowanceForNonAccountableExpensesOfPlacementAgents" id="tgtx_PercentageOfGrossProceedsFromOfferingAsAllowanceForNonAccountableExpensesOfPlacementAgents" type="num:percentItemType" abstract="false" xbrli:periodType="instant" nillable="true" substitutionGroup="xbrli:item"/>
<element name="SurrenderOfCommonStock" id="tgtx_SurrenderOfCommonStock" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="WarrantsExercisedEitherByPlacementAgentOrWarrantsIssued" id="tgtx_WarrantsExercisedEitherByPlacementAgentOrWarrantsIssued" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="PreferredStockConvertedIntoCommonStockPriorToConversion" id="tgtx_PreferredStockConvertedIntoCommonStockPriorToConversion" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="instant" nillable="true" substitutionGroup="xbrli:item"/>
<element name="NoninterestbearingMember" id="tgtx_NoninterestbearingMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="ConvertibleNotesMember" id="tgtx_ConvertibleNotesMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="IconConvertibleNotesMember" id="tgtx_IconConvertibleNotesMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="AmendmentAxis" id="tgtx_AmendmentAxis" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrldt:dimensionItem"/>
<element name="AmendmentDomain" id="tgtx_AmendmentDomain" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="BeforeAmendmentMember" id="tgtx_BeforeAmendmentMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="AfterAmendmentMember" id="tgtx_AfterAmendmentMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="ExchangeTransactionMember" id="tgtx_ExchangeTransactionMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="SwissPharmaMember" id="tgtx_SwissPharmaMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="AristonMember" id="tgtx_AristonMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="IconClinicalResearchMember" id="tgtx_IconClinicalResearchMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="ManhattanMember" id="tgtx_ManhattanMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="SettlementAgreementPayment" id="tgtx_SettlementAgreementPayment" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item"/>
<element name="WaiverPeriod" id="tgtx_WaiverPeriod" type="xbrli:durationItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="PromissoryNoteIssued" id="tgtx_PromissoryNoteIssued" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" xbrli:balance="credit" nillable="true" substitutionGroup="xbrli:item"/>
<element name="DebtInstrumentRenegotiatedPrice" id="tgtx_DebtInstrumentRenegotiatedPrice" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item"/>
<element name="PercentageOfCashProceedsFromOperationToRepayInterestOnConvertibleDebt" id="tgtx_PercentageOfCashProceedsFromOperationToRepayInterestOnConvertibleDebt" type="num:percentItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="OneTimeSettlementAmountForWaiverOfInterestAndPrincipalPayments" id="tgtx_OneTimeSettlementAmountForWaiverOfInterestAndPrincipalPayments" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item"/>
<element name="DebtInstrumentRepaymentTerm" id="tgtx_DebtInstrumentRepaymentTerm" type="xbrli:stringItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="WaiverPeriodInterestAndPrincipal" id="tgtx_WaiverPeriodInterestAndPrincipal" type="xbrli:durationItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="BusinessCombinationDebtInstrumentAmedmentDescription" id="tgtx_BusinessCombinationDebtInstrumentAmedmentDescription" type="xbrli:stringItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="ScheduleOfDeferredTaxAssetsAndLiabilitiesAbstract" id="tgtx_ScheduleOfDeferredTaxAssetsAndLiabilitiesAbstract" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="EffectiveIncomeTaxReconciliationForeignWithholdingTax" id="tgtx_EffectiveIncomeTaxReconciliationForeignWithholdingTax" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="credit" nillable="true" substitutionGroup="xbrli:item"/>
<element name="UsFederalIncomeTaxMember" id="tgtx_UsFederalIncomeTaxMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="LfbBiotechnologiesMember" id="tgtx_LfbBiotechnologiesMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="CollaborationAgreementMember" id="tgtx_CollaborationAgreementMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="StockIssuedDuringPeriodSharesLicenseOption" id="tgtx_StockIssuedDuringPeriodSharesLicenseOption" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="PossibleMilestonePayments" id="tgtx_PossibleMilestonePayments" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item"/>
<element name="BussinessAcquisitonPurchaseAgreementPeriodDescription" id="tgtx_BussinessAcquisitonPurchaseAgreementPeriodDescription" type="xbrli:stringItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="ContributionPerLicenceAgreementInExchangeOfCommonStock" id="tgtx_ContributionPerLicenceAgreementInExchangeOfCommonStock" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item"/>
<element name="CommonStockSharesSubscribedSubsidiarySaleOfStock" id="tgtx_CommonStockSharesSubscribedSubsidiarySaleOfStock" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="SharesIssuedForLicenceAgreementExchange" id="tgtx_SharesIssuedForLicenceAgreementExchange" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="PaymentsTowardsLicense" id="tgtx_PaymentsTowardsLicense" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="credit" nillable="true" substitutionGroup="xbrli:item"/>
<element name="PotentialRoyaltyPayment" id="tgtx_PotentialRoyaltyPayment" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item"/>
<element name="MilestonePayment" id="tgtx_MilestonePayment" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item"/>
<element name="PotentialFutureMilestonePayments" id="tgtx_PotentialFutureMilestonePayments" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item"/>
<element name="UpfrontFeeReceivedFromSubLicense" id="tgtx_UpfrontFeeReceivedFromSubLicense" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="credit" nillable="true" substitutionGroup="xbrli:item"/>
<element name="AdditionalAmountReceivableOnAchievementOfPreSpecifiedMilestones" id="tgtx_AdditionalAmountReceivableOnAchievementOfPreSpecifiedMilestones" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="credit" nillable="true" substitutionGroup="xbrli:item"/>
<element name="PotentialAdditionalAmountPayableOnAchievementOfPreSpecifiedMilestones" id="tgtx_PotentialAdditionalAmountPayableOnAchievementOfPreSpecifiedMilestones" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="credit" nillable="true" substitutionGroup="xbrli:item"/>
<element name="IncrementalCommonShareAttributableToSecurityExchangeAgreement" id="tgtx_IncrementalCommonShareAttributableToSecurityExchangeAgreement" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" xbrli:balance="credit" nillable="true" substitutionGroup="xbrli:item"/>
<element name="StatementScenariooAxis" id="tgtx_StatementScenariooAxis" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrldt:dimensionItem"/>
<element name="ScenariooUnspecifiedDomain" id="tgtx_ScenariooUnspecifiedDomain" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="ThorntonRossLtdMember" id="tgtx_ThorntonRossLtdMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="MinorityInterestInJointVenturePartners" id="tgtx_MinorityInterestInJointVenturePartners" type="num:percentItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="PlacementAgencyAgreementAxis" id="tgtx_PlacementAgencyAgreementAxis" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrldt:dimensionItem"/>
<element name="PlacementAgencyAgreementDomain" id="tgtx_PlacementAgencyAgreementDomain" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="LfbGroupMember" id="tgtx_LfbGroupMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="PlacementAgencyAgreementMember" id="tgtx_PlacementAgencyAgreementMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="RhizenMember" id="tgtx_RhizenMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="IssuancePeriodAxis" id="tgtx_IssuancePeriodAxis" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrldt:dimensionItem"/>
<element name="IssuancePeriodDomain" id="tgtx_IssuancePeriodDomain" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="TwoThousandElevenIssuanceMember" id="tgtx_TwoThousandElevenIssuanceMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="ResearchDevelopmentExpensesAxis" id="tgtx_ResearchDevelopmentExpensesAxis" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrldt:dimensionItem"/>
<element name="ResearchDevelopmentExpensesDomain" id="tgtx_ResearchDevelopmentExpensesDomain" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="ResearchDevelopmentExpensesMember" id="tgtx_ResearchDevelopmentExpensesMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="OpusMember" id="tgtx_OpusMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="LegalExpensesReimbursedToAgent" id="tgtx_LegalExpensesReimbursedToAgent" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item"/>
<element name="AdvisoryFeesExpensesPrivatePlacement" id="tgtx_AdvisoryFeesExpensesPrivatePlacement" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item"/>
<element name="AgentWarrantPercentageOnIssuanceOfShares" id="tgtx_AgentWarrantPercentageOnIssuanceOfShares" type="num:percentItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="AgentNonAccountableExpensePercentageOnGrossProceedsFromShareIssuance" id="tgtx_AgentNonAccountableExpensePercentageOnGrossProceedsFromShareIssuance" type="num:percentItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="NationalHoldingsMember" id="tgtx_NationalHoldingsMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" abstract="true" nillable="true"/>
<element name="CompensationAxis" id="tgtx_CompensationAxis" type="xbrli:stringItemType" substitutionGroup="xbrldt:dimensionItem" xbrli:periodType="duration" abstract="true" nillable="true"/>
<element name="CompensationDomain" id="tgtx_CompensationDomain" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" abstract="true" nillable="true"/>
<element name="RestrictedPreferredStockMember" id="tgtx_RestrictedPreferredStockMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" abstract="true" nillable="true"/>
<element name="RestrictedCommonStockMember" id="tgtx_RestrictedCommonStockMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" abstract="true" nillable="true"/>
<element name="CorrectionOfImmaterialErrorPolicyTextBlock" id="tgtx_CorrectionOfImmaterialErrorPolicyTextBlock" type="nonnum:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" abstract="false" nillable="true"/>
<element name="CashEquivalentsMaturityPeriod" id="tgtx_CashEquivalentsMaturityPeriod" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" abstract="false" nillable="true"/>
<element name="ShareBasedCompensationArrangementByShareBasedPaymentAwardOtherThanOptionsOutstandingNumber" id="tgtx_ShareBasedCompensationArrangementByShareBasedPaymentAwardOtherThanOptionsOutstandingNumber" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" abstract="false" nillable="true"/>
</schema>
