X0303 4 2010-03-03 0 0001001316 MANHATTAN PHARMACEUTICALS INC MHAN 0001304506 McGuinness Michael C/O MANHATTAN PHARMACEUTICALS, INC. 48 WALL STREET, SUITE 1110 NEW YORK NY 10005 0 1 0 0 COO & CFO Common Stock 10000 D Stock Options 0.70 2016-07-10 Common Stock 220000 220000 D Stock Options 1.35 2016-07-10 Common Stock 60000 60000 D Stock Options 0.95 2017-04-25 Common Stock 320000 320000 D Stock Options 0.17 2018-03-25 Common Stock 1100000 1100000 D Warrant 0.20 2013-09-10 Common Stock 24000 24000 D Stock Options 0.07 2010-03-03 4 A 0 2000000 0 A 2020-03-02 Common Stock 2000000 2000000 D The option vested as to 73,334 shares on July 10, 2007, and as to 73,333 shares on each of July 10, 2008 and July 10, 2009. The option vested as to 20,000 shares on each of July 10, 2007, July 10, 2008 and July 10, 2009. The option vested as to 106,667 shares on each of April 25, 2008 and April 25, 2009. The remaining 106,666 shares are scheduled to vest on April 25, 2010. The option vested as to 366,667 shares on each of March 25, 2008 and March 25, 2009. The remaining 366,666 shares are scheduled to vest on March 25, 2010. The warrant is exercisable immediately. On March 3, 2010, the reporting person was granted an option to purchase 2,000,000 shares of common stock of Manhattan Pharmaceuticals, Inc. under the 2003 Stock Option Plan. The vesting schedule of the option is as follows: (i) 1,000,000 shares vested on the date of grant, (ii) 333,333 shares are scheduled to vest on each of March 3, 2011 and March 3, 2012, and (iii) 333,334 shares are scheduled to vest on March 3, 2013. /s/ Michael G. McGuinness 2010-03-10