X0306 4 2021-02-25 0 0001001233 SANGAMO THERAPEUTICS, INC SGMO 0001600359 Hillan Kenneth J. C/O SANGAMO THERAPEUTICS, INC. 7000 MARINA BLVD BRISBANE CA 94005 1 0 0 0 Common Stock 2021-02-25 4 A 0 8200 0.00 A 23200 D Stock Option (Right to Buy) 11.19 2021-02-25 4 A 0 16400 0.00 A 2031-02-24 Common Stock 16400 16400 D Represents shares of common stock issuable upon settlement of restricted stock units ("RSUs"). The RSUs will fully vest on the first anniversary of the date of grant, subject to the Reporting Person's Continuous Service (as defined in the Issuer's Amended and Restated 2018 Equity Incentive Plan, as amended (the "2018 EIP, as amended")), through such date and subject to acceleration as provided in the 2018 EIP, as amended. Includes 15,000 shares of common stock issuable upon settlement of RSUs subject to Reporting Person's September 9, 2020 RSU grant that vest with respect to 1/3rd of the shares in three equal annual installments over the three-year period measured from the date of grant, subject to the Reporting Person's Continuous Service as defined in the 2018 EIP, as amended, through such dates and subject to acceleration as defined in the 2018 EIP, as amended. Each option is immediately exercisable for all option shares, but shares purchased under the option are subject to certain repurchase rights by the Issuer upon cessation of the Reporting Person's Continuous Service (as defined in the 2018 EIP, as amended). The shares subject to the option vest in 12 successive equal monthly installments upon the Reporting Person's completion of each month of Continuous Service (as defined in the 2018 EIP, as amended) over the 12-month period measured from the grant date and subject to acceleration as provided in the 2018 EIP, as amended. /s/ Matthew Colvin, Attorney-in-Fact for Kenneth J. Hillan, M.B., Ch.B. 2021-03-01